Changes in phenytoin concentrations in blood and cerebrospinal fluid caused by direct hemoperfusion in a patient intoxicated with phenytoin

Therapeutic Apheresis

Volumn 2, Issue 1, 1998, Pages 74-77

  Kanayama, Yuki ^a   Itakura, Yukihiro ^a   Iwasaki, Michio ^a   Hirahara, Yutaka ^a   Takasino, Suzuko ^a   Kawase, Yuko ^a   Katoh, Hitoshi ^a   Kinosita, Masanobu ^a   Matsumura, Osamu ^a   Mitarai, Tetsuya ^a   Isoda, Kazuo ^a  

^a SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Acute intoxication; Cerebrospinal fluid; Direct hemoperfusion; Phenytoin

Indexed keywords

PHENYTOIN;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG INTOXICATION; EPILEPSY; FEMALE; HEMOPERFUSION; HUMAN; PLASMAPHERESIS; PRIORITY JOURNAL;

EID: 17144471154     PISSN: 10916660     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1744-9987.1998.tb00077.x     Document Type: Article

References (7)

1. Lund L, Berlin A, Lumde PKM. Plasma protein binding of diphenylhydantoin in patients with epilepsy. Agreement between the unbound fraction in plasma and the concentration in cerebrospinal fluid. Clin Pharmacol Ther 1972;13:196-200.
2. Vajda F, Williams FM, Davidson S, Falconer MA, Breckenridge A. Human brain, cerebrospinal fluid, and plasma concentrations of diphenylhydantoin and phenobarbital. Clin Pharmacol Ther 1974;15:597-603.
3. Houghton GW, Richens A, Toseland PA, Davidson S, Falconer MA. Brain concentration of phenytoin, phenobarbitone and primidone in epileptic patients. Eur J Clin Pharmacol 1975;9:73-8.
4. Larsen JR, Larsen LS. Clinical features and management of poisoning due to phenytoin. Med Toxicol Adverse Drug Exp 1989;2:361-8.
5. Morikawa N, Mori K, Fujii I, Takeyama M. Pharmacokinetic study in acute antiepileptic intoxication treated with hemodialysis and hemoperfusion. Jpn J Clin Pharmacol Ther 1992; 23:469-74.
6. Schmidt D, Kopfersey HJ. Diphenylhydantoin, phenobarbital and primidone in saliva, plasma and cerebrospinal fluid. Epilepsia 1975;16:735-11.
7. Troupin AS, Friel P. Anticonvulsant level in saliva and serum and cerebrospinal fluid. Epilepsia 1975;16:223-7.