Strategy for development of a pre-erythrocytic Plasmodium falciparum DNA vaccine for human use

Vaccine

Volumn 15, Issue 8, 1997, Pages 842-845

  Hoffman, Stephen L ^a   Doolan, Denise L ^a   Sedegah, Martha ^a   Aguiar, Joao C ^a   Wang, Ruobing ^a   Malik, Anita ^a   Gramzinski, Robert A ^a   Weiss, Walter R ^a   Hobart, Peter ^b   Norman, Jon A ^b   Margalith, Michal ^b   Hedstrom, Richard C ^a  

^a NAVAL MEDICAL RESEARCH INSTITUTE   (United States)

^b VICAL INC   (United States)

Author keywords

DNA vaccine; Malaria; Pre erythrocytic stage

Indexed keywords

VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; ERYTHROCYTE MEMBRANE; GENETIC CODE; IMMUNIZATION; LIVER CELL; MALARIA; MEROZOITE; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PRIORITY JOURNAL; VACCINATION;

ANIMALS; ANTIGENS, PROTOZOAN; DISEASE MODELS, ANIMAL; DNA, PROTOZOAN; ERYTHROCYTES; HUMANS; MALARIA; MALARIA VACCINES; MALARIA, FALCIPARUM; MICE; MICE, INBRED BALB C; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PROTOZOAN PROTEINS; VACCINES, DNA;

EID: 17144469203     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(96)00273-3     Document Type: Conference Paper

References (10)

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2. Sedegah, M., Hedstrom, R., Hobart, P. and Hoffman, S.L. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proc. Natl Acad. Sci. USA 1994, 91, 9866-9870
3. + T cell, interferon-γ, and nitric oxide dependent immunity. J. Exp. Med. 1996, 183, 1739-1746
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7. Doolan, D.L., Hedstrom, R.C. and Rogers, W.O. et al. Identification and characterization of the protective hepatocyte erythrocyte protein 17 kDa gene of Plasmodium yoelii, homolog of Plasmodium falciparum Exported protein 1. J. Biol. Chem. 1996, 271, 17861-17868
8. Rogers, W.O., Malik, A. and Mellouk, S. et al. Characterization of Plasmodium falciparum sporozoite surface protein 2. Proc. Natl Acad. Sci. USA 1992, 89, 9176-9180
9. Guerin-Marchand, C., Druilhe, P. and Galey, B. et al. A liver-stage-specific antigen of Plasmodium falciparum characterized by gene cloning. Nature 1987, 329, 164-167
10. Hill, A.V.S., Allsopp, C.E.M. and Kwiatkowki, D. et al. Common West African HLA antigens are associated with protection from severe malaria. Nature 1991, 352, 595-600