Thymic dysfunction and time of infection predict mortality in human immunodeficiency virus-infected infants

Journal of Infectious Diseases

Volumn 178, Issue 3, 1998, Pages 680-685

  Nahmias, André J ^a   Scott Clark, W ^b   Kourtis, Athena P ^b   Lee, Francis K ^b   Cotsonis, George ^b   Ibegbu, Christian ^b   Thea, Donald ^b   Palumbo, Paul ^b   Vink, Peter ^b   Simonds, R J ^b   Nesheim, Steven R ^b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; LYMPHOCYTE COUNT; LYMPHOPOIESIS; MAJOR CLINICAL STUDY; PATHOGENESIS; PRIORITY JOURNAL; VIRUS LOAD; VIRUS TRANSMISSION;

EID: 17144458060     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/515368     Document Type: Article

References (15)

1. + T lymphocyte regeneration after intensive chemotherapy. N Engl J Med 1995;332:143-9.
2. Kourtis AP, Ibegbu C, Nahmias AJ, et al. Early progression of disease in HIV-infected infants with thymus dysfunction. N Engl J Med 1996;335:1431-6.
3. + B lymphocyte decreases in infants with the DiGeorge thymic anomaly. Scand J Immunol 1997;46:281-3.
4. Bryson YL, Luzuriaga K, Sullivan JL, et al. Proposed definitions for in utero versus intrapartum transmission of HIV-1. N Engl J Med 1992;327:1246-7.
5. Palumbo P, Raskino C, Fiscus S, et al. Predictive value of quantitative plasma HIV RNA and CD4 lymphocyte count in HIV-infected infants and children. JAMA 1998;279:756-62.
6. Simmonds RJ, Stekette R, Nesheims S, et al. Impact of zidovudine use on risk and risk factors for perinatal transmission of HIV. AIDS 1998;12:301-8.
7. Ibegbu C, Spira TJ, Nesheim SR, et al. Subpopulations of T and B cells in perinatally HIV-infected and noninfected age-matched children compared with those in adults. Clin Immunol Immunopathol 1994;71:27-32.
8. Blanche S, Tardieu M, Duliege A, et al. Longitudinal study of 94 symptomatic infants with perinatally acquired human immunodeficiency virus infection: evidence for a bimodal expression of clinical and biological symptoms. Am J Dis Child 1990;144:1210-5.
9. The European Collaborative Study. Natural History of vertically acquired human immunodeficiency virus-I infection. Pediatrics 1994;94:815-9.
10. Borkowsky W, Krasinski K, Cao Y, et al. Correlation of perinatal transmission of human immunodeficiency virus type 1 with maternal viremia and lymphocyte phenotypes. J Pediatr 1994;125:345-51.
11. Mayaux MJ, Burgard M, Teglas JP, et al. Neonatal characteristics in rapidly progressive perinatally acquired HIV-1 disease. JAMA 1996;275:606-10.
12. Nahmias A, Lee FK, Kourtis A, Ibegbu I. Immunology of HIV infection in the fetus and newborn. Clin Immunol 1998;18:401-19.
13. Nahmias A, Kourtis A. The great balancing acts: the pregnant woman, placenta, fetus, and infectious agents. Clin Perinatol 1997;24:497-521.
14. Fauci AS. The immunopathogenesis of human immunodeficiency virus infection. N Engl J Med 1993;328:327-35.
15. Levy JA. HIV and the pathogenesis of AIDS. 2nd ed. Washington, DC: American Society for Microbiology Press, 1998.