The effect of meclofenoxate with ginkgo biloba extract or zinc on lipid peroxide, some free radical scavengers and the cardiovascular system of aged rats

Pharmacological Research

Volumn 38, Issue 1, 1998, Pages 65-72

  Al Zuhair, Hana ^a   Abd El Fattah, Amal A ^b   El Sayed, Moushira Ibrahim ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Aging; Gingko biloba extract; Meclofenoxate; Rats; Zinc

Indexed keywords

ANTIOXIDANT; CENTRAL STIMULANT AGENT; GINKGO BILOBA EXTRACT; GLUTATHIONE; LIPID PEROXIDE; MALONALDEHYDE; MECLOFENOXATE; MEMBRANE PHOSPHOLIPID; PHOSPHOLIPID; PLANT EXTRACT; SCAVENGER; SUPEROXIDE DISMUTASE; THIOL; ZINC;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD; BLOOD PRESSURE; BRAIN; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; ENZYME ACTIVITY; HEART; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; LIPID PEROXIDATION; LIVER; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

GINKGO BILOBA;

EID: 17144450885     PISSN: 10436618     EISSN: None     Source Type: Journal    
DOI: 10.1006/phrs.1998.0333     Document Type: Article

References (51)

1. 1. Bunker VW. Free radicals, antioxidants and aging. Med Lab Sci 1992; 49: 299-312.
2. 2. Kanter MM. Free radicals, exercise and antioxidant supplementation. Int J Sport Nutr 1994; 4: 205-20.
3. 3. Harman D. Free radical theory of aging. Triangle 1973; 12: 153-8.
4. 4. Ward J. Free radicals, antioxidants and preventive geriatrics. Aust Fam Phys 1994; 23: 1297-301.
5. 5. Halliwell B, Murcia MA, Chirico S, Aruoma OI. Free radicals and antioxidants in food and in vivo: What they do and how they work. Crit Rev Food Sci Nutr 1995; 35: 7-20.
6. 6. Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 1993; 23: 21-48.
7. 7. Hanstein WG, Hatefi Y. Lipid oxidation in biological membranes. II. Kinetics and mechanism of lipid peroxidation in submitochondrial particles. Arch Biochem 1970; 138: 87-95.
8. 8. Frolkis VV, Frolkis RA, Dubur-G YA, Khmele VsKy, Yu V, Shevchuk VG, Golovchenko SF, Mkhitarjan LS, Voronko GS, Tsyomik VA, Lysenko IV. Antioxidants as antiarrythmic drugs. Cardiology 1987; 74: 124-32.
9. 9. Nagy ZsI, Fieri C, Del Moro M. Effects of centrophenoxine on the monovalent electrolyte contents of the large brain cortical cells of old rats. Gerontology 1979; 25: 94-102.
10. 10. Barber DA, Harris SR. Oxygen free radicals and antioxidants: a review. Am Pharm 1994; NS34: 26-35.
11. 11. Kleijnen J, Knipschild P. Ginkgo biloba. Lancet 1992; 340: 1136-9.
12. 12. Pincemail J, Dupuis M, Nasr C, Hans P, Haag-Berrurier M, Anton R, Deby C. Superoxide anion scavenging effect and superoxide dismutase activity of Ginkgo biloba extract. Experientia 1989; 45: 708-12.
13. 13. Bettger WJ, O'Dell BC. A critical physiological role of zinc in the structure and function of biomembranes. Life Sci 1982; 28: 1425-38.
14. 14. Woodward WD, Filteau SM, Allen OB. Decline in serum zinc level throughout adult life in the laboratory mouse. J Gerontol 1984; 39: 521-4.
15. 15. El Tahir KEH, El-Naser MAS, Ageel AM, El-Obeid HA, Al Rashood KA. The cardiovascular depressant effects of N-Methyl and N-isobutyl-1,2-diphenylethanolamine: Elucidation of the mechanisms of action. Arch Int Pharmacodyn Ther 1991; 309: 88-102.
16. 16. El Tahir KEH, Ashour MMS, Al Harbi MM. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol 1993; 42: 1123-31.
17. 17. Patro N, Sharma SP, Patro IK. Lipofuscin accumulation in ageing myocardium and its removal by meclophenoxate. Indian J Med Res 1992; 96: 192-8.
18. 18. Woo, PCY, Kaan SK, Cho CH. Evidence for potential application of zinc as an antidote to acetaminophen-induced hepatotoxicity. Eur J Pharmacol Envrion Toxicol Pharmacol Section 1995; 293: 217-24.
19. 19. Koster JF, Biemond P, Swaak AJG. Intracellular and extracellular sulph-hydryl levels in rheumatoid arthritis. Ann Rheum Dis 1986; 45: 44-6.
20. 20. Raheja RK, Kaur C, Singh A, Bahtia IS. New colorimetric method for the quantitative estimation of phospholipids without acid digestion. J Lipid Res 1973; 14: 695-7.
21. 21. Beutler E, Duron D, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med 1963; 61: 882-8.
22. 22. Uchiyama M, Mihara M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978; 86: 271-8.
23. 23. Winterbourn CC, Hawkins RE, Brain M, Carrell RW. The estimation of red cell superoxide dismutase activity. J Lab Clin Med 1975; 85: 337-41.
24. 24. Folch J, Less M, Sloane-Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 1970; 226: 497-509.
25. 25. Maral J, Puget K, Michelson AM. Comparative study of superoxide dismutase, catalase and glutathione peroxidase levels in erythrocyte of different animals. Biochem Biophys Res Commun 1977; 77: 1525-35.
26. 26. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent 1951; 193: 265-75.
27. 27. Goyal VK. Early appearance and rate of lipofuscin pigment accumulation in human myocardium. Exp Gerontol 1981; 16: 219-22.
28. 2-adrenergic receptors in brain tissue of aged rats. J Gerontol 1984; 39: 538-46.
29. 3H)prazosin binding by chronic treatment with desipramine and AR-C239. Arch Int Pharmacol Ther 1990; 305: 5-13.
30. 30. Gutteridge JM. Biological origin of free radicals and mechanisms of antioxidant protection. Chem Biol Interact 1994; 91: 133-40.
31. 31. Lippman RD. Lipid peroxidation and metabolism in aging: a biological, chemical and medical approach. In: Rothstein M ed. Review of Biological Research in Aging, vol 1. New York: Alan R. Liss, 1983: pp. 352-42.
32. 32. Nohl H, Kraemer R. Molecular basis of age-dependent changes in the activity of adenine nucleotide translocase. Mech Ageing Dev 1980; 14: 137-44.
33. 33. Porta EA, Nitta RT, Kia L, Joun NS, Nguyen L. Effect of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. II. Biochemical and morphometric parameters of the brain. Mech Ageing Dev 1980; 13: 319-55.
34. 34. Halliwell B, Gutteridge JMC. Protection against oxidants in biological systems, the superoxide theory of oxygen toxicity. In: Halliwell B, Gutteridge JMC, eds. Free Radicals in Biology and Medicine, 2nd ed. Clarendon Press, 1989: pp. 152-6.
35. 35. Scarpa M, Rigo A, Viglino P, Stevanato R, Bracco F, Battistin L. Age dependence on the level of the enzymes involved in the protection against active oxygen species in the rat brain (42526). Proc Soc Exp Biol Med 1987; 185: 129-33.
36. 36. Nohl H, Hegner D, Summer KH. Responses of mitochondrial superoxide dismutase, catalase and glutathione peroxidase activities to aging. Mech Ageing Dev 1979; 11: 145-51.
37. 37. Govinda R, Xia E, Nadakavukaren MJ, Richardson A. Effect of dietary restriction on the age-dependent changes in the expression of antioxidant enzymes in rat liver. J Nutr 1990; 120: 602-9.
38. 38. Stohs SJ, Hassing JM, Al-Turk WA, Masoud AN. Glutathione levels in hepatic and extrahepatic tissues of mice as a function of age. Age 1980; 3: 11-14.
39. 39. Prothro J. Protein and amino acid requirements of the elderly. Ann NY Acad Sci 1989; 561: 143-56.
40. 40. Sharma D, Singh R. Centrophenoxine activates acetyl cholinesterase activity in hippocampus of aged rats. Indian J Exp Biol 1995; 33: 365-8.
41. 41. Petkov VD, Stancheva SL, Tocuschieva L, Petkov VV. Changes in brain biogenic monoamines induced by nootropic drugs adafenoxate and meclofenoxate and by citicholine on rats. Gen Pharmacol 1990; 21(1): 71-5.
42. 2 modulation by dietary restriction. Mech Ageing Dev 1992; 65: 17-33.
43. 43. Wood WG, Gorka C, Armbrecht J, Williamson LS, Strong R. Fluidizing effects of centrophenoxine in vitro on brain and liver membranes from different age groups of mice. Life Sci 1986; 39: 2089-95.
44. 44. De Feudis FV. Mechanisms and concepts of action of EGB761: theoretical considerations. In: De Feudis FV, ed. Ginkgo biloba Extract (EGB 761): Pharmacological Activities and Clinical Applications. Paris: Elsevier, 1991: pp. 147-52.
45. 45. Braquet P, Spinnewyn B, Braquet M, Bourgain RH, Taylor JE, Etienne A, Drieu K. BN52021 and related compounds: a new series of highly specific PAF-acether receptor antagonists isolated from gingko biloba. Blood Vessels 1985; 16: 559-72.
46. 46. Taylor JE. Effects de L'administration chronique de Ginkgo biloba. La Press Medicale 1986; 15: 1491-3.
47. 47. Welt K, Fitzl G, Schaffraniet ZL. Myocardium-protective effects of Ginkgo extract (EGb 761) in old rats against acute isobaric hypoxia. An electron microscopic morphometric study. II, protection of microvascular endothelium. Exp Toxicol Pathol 1996; 48: 81-6.
48. 48. Avdonin PV, Cheglakov IB, Borgry EM, Svitina-Ulitina I, Mazaev AV, Thachuk VA. Evidence for the receptor operated calcium channels in human platelet plasma membrane. Thromb Res 1987; 46: 29-37.
49. 49. Majewska MD, Strosznajder J, Lazarewicz J. Effect of ischemic anoxia and barbiturate anaesthesia on free radical oxidation of mitochondrial phospholipids. Brain Res 1978; 158: 423-34.
50. 50. Stohs SJ and Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radical Biol Med 1995; 18: 321-36.
51. 51. Günther T, Grossrau R, Höllriegl V, Vormann J. Effect of Fe, salicylate, Zn on metallothionein and lipid peroxidation in vivo. J Trace Elem Electrolytes Health Dis 1991; 5: 95-100.