Intestinal aspects of cholesterol gallstone formation

Digestive and Liver Disease

Volumn 35, Issue SUPPL. 3, 2003, Pages 8-11

  van Erpecum, K J ^a   van Berge Henegouwen, G P ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Deoxycholate; Gallbladder motility; Gallstone; Intestinal motility

Indexed keywords

BILE SALT; DEOXYCHOLIC ACID; MOTILIN;

ARTICLE; CHOLECYSTECTOMY; CHOLESTEROL STONE; CLINICAL TRIAL; DEFECATION; DIET RESTRICTION; FECES INCONTINENCE; FEMALE; GALLBLADDER CONTRACTION; GALLBLADDER EMPTYING; GALLBLADDER MOTILITY; HORMONE BLOOD LEVEL; HORMONE RELEASE; HUMAN; INTESTINE ABSORPTION; INTESTINE MOTILITY; INTESTINE TRANSIT TIME; MAJOR CLINICAL STUDY; PATHOGENESIS; PATHOPHYSIOLOGY; RISK; BLOOD; CHOLELITHIASIS; GALLSTONE; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; PHYSIOLOGY; REVIEW;

CHOLECYSTOLITHIASIS; FASTING; GALLBLADDER EMPTYING; GALLSTONES; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRANSIT; HUMANS; MOTILIN;

EID: 17144448551     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1590-8658(03)00086-0     Document Type: Article

References (25)

1. Apstein MD, Carey MC. Pathogenesis of cholesterol gallstones: a parsimonious hypothesis. Eur J Clin Invest 1996;26:343-52.
2. van Erpecum KJ, van Berge-Henegouwen GP. Gallstones: an intestinal disease? Gut 1999;44:435-8.
3. Shoda J, He B-F, Tanaka N, Matsuzaki Y, Osuga T, Yamamori S, et al. Increase of deoxycholate in supersaturated bile of patients with cholesterol gallstone disease and its correlation with de novo syntheses of cholesterol and bile acids in liver, gallbladder emptying, and small intestinal transit. Hepatology 1995;21:1291-302.
4. Heaton KW, Emmett PM, Symes CL, Braddon FEM. An explanation for gallstones in normal-weight women: slow intestinal transit. Lancet 1993;341:8-10.
5. Thomas LA, Veysey MJ, Bathgate T, King A, French G, Smeeton NC, et al. Mechanism for the transit-induced increase in colonic deoxycholic acid formation in cholesterol cholelithiasis. Gastroenterology 2000;119:806-15.
6. Xu Q-W, Scott RB, Tan DTM, Shaffer EA. Slow intestinal transit: a motor disorder contributing to cholesterol gallstone formation in the ground squirrel. Hepatology 1996;23:1664-72.
7. Wang DQH, Paigen B, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: physical-chemistry of gallbladder bile. J Lipid Res 1997;38:1395-411.
8. van Erpecum KJ, Wang DQ-H, Lammert F, Paigen B, Groen AK, Carey MC. Phenotypic characterization of Lith genes that determine susceptibility to cholesterol cholelithiasis in inbred mice: soluble pronucleating proteins in gallbladder and hepatic biles. J Hepatol 2001;35:444-51.
9. Hauser H, Dyer JH, Nandy A, Vega MA, Werder M, Bieliauskaite E, et al. Identification of a receptor mediating absorption of dietary cholesterol in the intestine. Biochemistry 1998;37:17843-50.
10. Berge KE, Tian H, Graf GA, Yu L, Grishin NV, Schultz J, et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 2000;290:1771-5.
11. Denson LA, Sturm E, Echevarria W, Zimmerman TL, Makishima M, Mangelsdorf DJ, et al. The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter. Gastroenterology 2001;121:140-7.
12. Gerloff T, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, et al. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem 1998;273:10046-50.
13. Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 2000;6:517-26.
14. Lu TT, Makishima M, Repa JJ, Schoonjans K, Kerr TA, Auwerx J, et al. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell 2000;6:507-15.
15. van Erpecum KJ, Carey MC. Influence of bile salts on molecular interactions between sphingomyelin and cholesterol: relevance to bile formation and stability. Biochim Biophys Acta 1997;1345:269-82.
16. Wang DQH, Carey MC. Complete mapping of crystallization pathways during cholesterol precipitation from model bile: influence physical-chemical variables of pathophysiologic significance and identification of a stable liquid-crystalline state in cold, dilute and hydrophilic bile salt-containing systems. J Lipid Res 1996;37:606-30.
17. Moschetta A, van Berge-Henegouwen GP, Portincasa P, Palasciano G, van Erpecum KJ. Cholesterol crystallization in model biles. Effects of bile salt and phospholipid species composition. J Lipid Res 2001;42:1273-81.
18. Hussaini SH, Pereira SP, Murphy GM, Dowling RH. Deoxycholic acid influences cholesterol solubilization and microcrystal nucleation time in gallbladder bile. Hepatology 1995;22:1735-44.
19. Hussaini SH, Murphy GM, Kennedy C, Besser GM, Wass JAH, Dowling RH. The role of bile composition and physical chemistry in the pathogenesis of octreotide-associated gallbladder stones. Gastroenterology 1994;107:1503-13.
20. Veysey MJ, Malcolm P, Mallet AI, Jenkins PJ, Besser GM, Murphy GM, et al. Effects of cisapride on gall bladder emptying, intestinal transit, and serum deoxycholate: a prospective, randomised, double blind, placebo controlled trial. Gut 2001;49:828-34.
21. Jorgensen T. Abdominal symptoms and gallstone disease: an epidemiological investigation. Hepatology 1989;9:856-60.
22. Dukas L, Leitzmann MF, Willett WC, Colditz GA, Giovannucci EL. Association of bowel movement frequency and use of laxatives with the occurrence of symptomatic gallstone disease in a prospective study of women. Am J Gastroenterol 2001;96:715-21.
23. Stolk MFJ, van Erpecum KJ, Smout AJPM, Akkermans LMA, Jansen JB, Lamers CB, et al. Motor cycles with phase III in antrum are associated with high motilin levels and prolonged gallbladder emptying. Am J Physiol 1993;264:G596-600.
24. van Erpecum KJ, van Berge-Henegouwen GP, Stoelwinder B, Schmidt YMG, Willekens FLH. Bile concentration is a key factor for nucleation of cholesterol crystals and cholesterol saturation index in gallbladder bile of gallstone patients. Hepatology 1990;11:1-6.
25. Stolk MF, van Erpecum KJ, Peeters TL, Samsom M, Smout AJ, Akkermans LM, et al. Interdigestive gallbladder emptying, antroduodenal motility, and motilin release patterns are altered in cholesterol gallstone patients. Dig Dis Sci 2001;46:1328-34.