Optimal hematocrit for the maximum oxygen delivery to the brain with recombinant human erythropoietin in hemodialysis patients

Clinical Nephrology

Volumn 53, Issue 5, 2000, Pages 354-361

  Hirakata, H ^a   Kanai, H ^a   Fukuda, K ^a   Tsuruya, K ^a   Ishida, I ^a   Kubo, M ^a   Hirano, T ^a   Hirakata, E ^a   Kuwabara, Y ^a   Fujishima, M ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Brain function; Erythropoietin; Hemodialysis; Optimal hematocrit; Oxygen delivery

Indexed keywords

RECOMBINANT ERYTHROPOIETIN;

ARTERIAL OXYGEN TENSION; ARTICLE; BLOOD GAS ANALYSIS; BRAIN BLOOD FLOW; BRAIN FUNCTION; BRAIN METABOLISM; FEMALE; HEMATOCRIT; HEMODIALYSIS; HUMAN; OXYGEN TRANSPORT; POSITRON EMISSION TOMOGRAPHY;

ANEMIA; BRAIN; CEREBROVASCULAR CIRCULATION; ERYTHROPOIETIN, RECOMBINANT; FEMALE; HEMATOCRIT; HUMANS; MIDDLE AGED; OXYGEN; RENAL DIALYSIS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 17144447526     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Anonymous 1997 NKF-DOQI clinical practice guidelines for the treatment of anemia of chronic renal failure. National Kidney Foundation-Dialysis Outcomes Quality Initiative. Am J Kidney Dis 30 (Suppl 3): S192-S240
2. Beusterien KM. Nissenson AR, Port FK, Kelly M, Steinwald B, Ware JE Jr 1996 The effects of recombinant human erythropietin on functional health and well-being in chronic dialysis patients. J Am Soc Nephrol 7: 763-773
3. Brown WS, Marsh JT, Wolcott D, Takushi R, Carr CR, Higa J, Nissenson AR 1991 Cognitive function, mood and P3 latency: effects of the amelioration of anemia in dialysis patients. Neuropsychologia 29: 35-34
4. Besarab A, Bolton K, Browne JK, Egrie JC, Nissenson AR, Okamoto DM, Schwab SJ, Goodkin DA 1998 The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoctin. N Engl J Med 339: 584-590
5. Collins, AJ, Keane WF 1998 Higher hematocrit levels: do they improve patient outcomes, and are they cost effective?. Nephrol Dial Transplant 13: 1627-1629
6. Fan F-C, Chen RYZ, Schussler GB, Chien S 1980 Effects of hematocrit variations on regional hemodynamics and oxygen transport in the dog. Am J Physiol 238: H545-H552
7. 15O and positron emission tomography: theory, procedure, and normal values. J Comput Assist Tomogr 4: 727-736
8. Friedland RP, Grant S 1979 Hematocrit, viscosity and cerebral blood flow. Am Heart J 97: 404-405
9. Grimm G, Stockenhuber F, Schneeweiss B. Madl C, Zeitlhofer J, Schneider B 1990 Improvement of brain function in hemodialysis patients treated with erythropoietin. Kidney Int 38: 480-486
10. Hendrix WR 1996 Epoetin alfa - focus on optimal hematocrit. Case study of the anemic patient. Anna Journal 23: 46-49
11. Herold S, Brozovic M, Gibbs J, Lammertsma AA, Leeders KL, Carr D, Fleming JS, Jones T 1986 Measurement of regional cerebral blood flow, blood volume and oxygen metabolism in patients with sickle cell disease using positron emission tomography. Stroke 17: 692-698
12. Hirakata H, Yao H, Oosato S, Ibayashi S, Onoyama K, Otsuka M, Ichiya Y, Kuwabara Y, Masuda Y, Fujishima M 1992 CBF and oxygen metabolism in hemodialysis patients: effects of anemia correction with recombinant human EPO. Am J Physiol 262: F737-F743
13. Kannel WB, Gordon T, Wolf PA, McNamara P 1972 Hemoglobin and the risk of cerebral infarction: The Framingham Study. Stroke 3: 409-420
14. Kiyahora Y, fujishima M, Ishitsuku T, Tamaki K, Sadoshima M, Omae T 1985 Effects of hematocrit on brain metabolism in experimentally induced cerebral ischemia in spontaneously hypertensive rats (SHR). Stroke 16: 835-840
15. Kusunoki M, Kimura K, Nakamura M, Isaka Y. Yoneda S 1981 Effects of hematocrit variations on cerebral blood flow and oxygen transport in ischemic cerebrovascular disease. J Cereb Blood Flow Metab 1: 413-417
16. Locatelli F, Conte F and Marcelli D 1998 The impact of hematocrit levels and erythropoietin treatment on overall and cardiovascular mortality and morbidity the experience of the Lombardy Dialysis Registry. Nephrol Dial Transplant 13: 1642-1644
17. Marsh JT, Brown WS, Wolcott D, Carr CR, Harper R, Schweitzer SV, Nissenson AR 1991 rHuEPO treatment improves brain and cognitive function of anemic dialysis patients. Kidney Int 39 155-163
18. Metry G, Wikstrom B, Valind S, Sandhagen B. Linde T. Beshara S, Langstrom B, Danielson BG 1999 Effect of normalization of hematocrit on brain circulation and metabolism in hemodialysis patients. J Am Soc Nephrol 10: 854-863
19. Ott EO, Uchner H. Aranihar A 1974 High blood viscosity syndrome in cerebral infaretion. Stroke 5: 330-333
20. Paganini EP 1994 In search of an optimal hematocrit level in dialysis patients: rehabilitation and quality-of-life implications. Am J Kidney Dis 24 (Suppl 1): S10-16
21. Thomas DJ, DuBoulay GH, Marshall J, Pearson TC, Ross Russell RW, Symon L, Wetherley-Mein G, Zilkha E 1977 Cerebral blood-flow in polyeythemia. Lancet II: 161-163
22. Wolcott DL, Marsh JT, La Rue A, Carr C, Nissenson AR 1989 Recombinant human erythropoietin treatment may improve quality of life and cognitive function in chronic hemodialysis patients. Am J Kidney Dis 14: 478-485