Inhibitory effects of tachykinin receptor antagonists on thermally induced inflammatory reactions in a rat model

Burns

Volumn 25, Issue 2, 1999, Pages 125-129

  Lofgren O ^a,b   Qi, Y ^a   Lundeberg, T ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Edema; Nociception; Sensory peptide antagonists

Indexed keywords

HOT WATER; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROPEPTIDE; SUBSTANCE P; TACHYKININ; TACHYKININ RECEPTOR ANTAGONIST;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; INFLAMMATION; LATENT PERIOD; MALE; MECHANICAL STIMULATION; NEUROTRANSMISSION; NOCICEPTION; PAW EDEMA; PLETHYSMOGRAPH; PRESYNAPTIC INHIBITION; RAT; SCALD; SPINAL CORD; THERMAL INJURY; WITHDRAWAL REFLEX;

ANIMALS; BURNS; DISEASE MODELS, ANIMAL; EDEMA; FOLLOW-UP STUDIES; INFLAMMATION; MALE; NEUROKININ A; NOCICEPTORS; PAIN MEASUREMENT; PEPTIDE FRAGMENTS; PYRROLIDONECARBOXYLIC ACID; QUINUCLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; SKIN DISEASES; SUBSTANCE P;

EID: 17144444342     PISSN: 03054179     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0305-4179(98)00125-9     Document Type: Article

References (20)

1. Yonehara N., Shibutani T., Inoki R. Contribution of substance P to heat-induced edema in rat paw. J Pharmacol Exp Ther. 242:1987;1071-1076.
2. Löfgren O., Palmer B., Theodorsson E., Törkvist L., Lundeberg T. Contribution of the sensory and sympathetic nervous system to scalding-induced edema in the rat paw. Burns. 24:1998;188-195.
3. Siney L., Brain S.D. Involvement of sensory neuropeptides in the development of plasma extravasation in rat dorsal skin following thermal injury. Br J Pharmacol. 117:1996;1065-1070.
4. Levine J.D., Fields H.L., Basbaum A.I. Peptides and the primary afferent nociceptor. J Neurosci. 13:1993;2273-2286.
5. Wiesenfeld-Hallin Z., Xu X.J. The differential roles of substance P and neurokinin A in spinal cord hyperexcitability and neurogenic inflammation. Regul Peptides. 46:1993;165-173.
6. Quartara L., Maggi C.A. The tachykinin NK1 receptor. Part II: distribution and pathophysiological roles. Neuropeptides. 32:1998;1-49.
7. Hökfelt T. Neuropeptides in perspective: the last ten years. Neuron. 7:1991;867-879.
8. Xu X.J., Dalsgaard C.J., Maggi C.A., Wiesenfeld-Hallin Z. NK-1, but not NK-2, tachykinin receptors mediate plasma extravasation induced by antidromic C-fiber stimulation in rat hindpaw: demonstrated with the NK-1 antagonist CP-96,345 and the NK-2 antagonist Men 10207. Neurosci Lett. 139:1992;249-252.
9. Lund T., Onarheim H., Reed R.K. Pathogenesis of edema formation in burn injuries. World J Surg. 16:1992;2-9.
10. Arturson G. Pathophysiology of the burn wound and pharmacological treatment. The Rudi Hermans lecture, 1995. Burns. 22:1996;255-274.
11. Haegerstrand A. Sensory neuropeptides in inflammation and cell proliferation. Ph.D. thesis, University of Stockholm, 1990.
12. Saria A., Lundberg J.M. Capsaicin pretreatment inhibits heat-induced oedema in the rat skin. Naunyn-Schmiedeberg's Arch Pharmacol. 323:1983;341-342.
13. Lundberg J.M., Saria A., Rosell S., Folkers K. A substance P antagonist inhibits heat-induced oedema in the rat skin. Acta Physiol Scand. 120:1984;145-146.
14. Löfgren O., Gazelius B., Lundeberg T. Acute microcirculatory changes after scalding of the rat paw. Acta Physiol Scand. 161:1997;289-294.
15. Löfgren O, Qi Y, Lundeberg T, Gazelius B. Antagonists of sensory neuropeptides inhibit the secondary phase of increased circulation following thermally induced inflammation, Microv Res (In press).
16. Duggan A.W., Hope P.J., Jarrott B., Schaible H.G., Fleetwood-Walker S.M. Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation: studies with antibody microprobes. J Neurosci. 35:1990;195-202.
17. Bileviciute I., Lundeberg T., Ekblom A., Theodorsson E. Bilateral changes of substance P-, neurokinin A-, calcitonin gene-related peptide- and neuropeptide Y-like immunoreactivity in rat knee joint synovial fluid during acute monoarthritis. Neurosci Lett. 153:1993;37-40.
18. 8-37 results in a bilateral increase in hindpaw withdrawal latency in rats with a unilateral thermal injury. Neuropeptides. 6:1997;601-607.
19. Mayer E.A., Raybould H., Koelbel C. Neuropeptides, inflammation and motility. Dig Dis Sci. 33:1988;71S-77S.
20. Sluka K.A., Willis W.D., Westlund K.N. The role of dorsal root reflexes in neurogenic inflammation. Pain Forum. 4:1995;141-149.