Synthesis of fused bicyclic pyridines with microwave-assisted intramolecular hetero-Diels-Alder cycloaddition of acetylenic pyrimidines

Tetrahedron Letters

Volumn 46, Issue 19, 2005, Pages 3423-3427

  Shao, Bin ^a  

^a Purdue Pharma Discovery Research   (United States)

Author keywords

Acetylene; Hetero Diels Alder cycloaddition; Heterocycle; Intramolecular; Microwave; Pyrimidine

Indexed keywords

ACETYLENE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ALKYLATION; ARTICLE; CYCLOADDITION; DIELS ALDER REACTION; ENERGY YIELD; MICROWAVE RADIATION; MOLECULAR INTERACTION; REACTION ANALYSIS; REACTION TIME; STRUCTURE ANALYSIS; SYNTHESIS;

BETULACEAE;

EID: 17144428907     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.03.098     Document Type: Article

References (10)

1. Details will be published elsewhere
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9. The microwave-assisted reactions were carried out in a Microsynth from Milestone with maximum power output of 1000 W. The reaction temperature profiles used were: 22-280°C in 1 min, hold at 280°C for 2.5 min then power off to cool down to room temperature. For substrate 5 only, 22-265°C in 1 min, hold at 265°C for 45 min, then power off to cool down to room temperature
10. 2 requires C, 71.62; H, 6.31; N, 12.53