Intrathecal opioid conversions: The importance of lipophilicity

Neuromodulation

Volumn 1, Issue 4, 1998, Pages 195-197

  Royal, Mike A ^a,b   Wiesemeyer, Dan L ^a   Gordin, Vitaly ^a  

^a Oklahoma University   (United States)

^b Pain Evaluation and Treatment Center   (United States)

Author keywords

Intraspinal; Neuromodulation; Opiates pain; Pumps

Indexed keywords

EID: 17144427780     PISSN: 10947159     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1525-1403.1998.tb00016.x     Document Type: Article

References (5)

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2. Gourlay GK, Cherry DA, Plummer JL, Armstrong PJ, Cousins MJ. The influence of drug polarity on the absorption of opioid drugs into CSF and subsequent cephalad migration following lumbar epidural administration: Application to morphine and pethidine. Pain 1987;31: 297-305.
3. Max M, Inturrisi CE. Epidural and intrathecal opioids: Cerebrospinal fluid and plasma profiles in cancer pain patients. Clin Pharmacol Ther 1985;38:631-641.
4. Gourlay GK, Murphy TM, Plummer JL, Kowalski SR, Cherry DA, Cousins MJ. Pharmacokinetics of fentanyl in lumbar and cervical CSF following lumbar epidural and intravenous administration. Pain 1989;38:253-259.
5. Belzarena SD. Clinical effects of intrathecally administered fentanyl in patients undergoing cesarean section. Anesth Analg 1992;74:677-682.