Anti-oxidative and mitochondria-protective effects of extract of astragalus on focal cerebral ischemia-reperfusion injury in rats

Chinese Pharmacological Bulletin

Volumn 21, Issue 2, 2005, Pages 216-219

  Min, Xiao Fen ^a   Li, Wei Ping ^a   Wang, Shao Bin ^a   He, Ting ^a   Yin, Yan Yan ^a   Ming, Liang ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Cerebral ischemia reperfusion; Extract of astragalus; Free radical; Mitochondrion

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ASTRAGALUS EXTRACT; CALCIUM ION; LACTIC ACID; MAGNESIUM ION; MALONALDEHYDE; OXYGEN RADICAL; PLANT EXTRACT; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASTRAGALUS PLANT; BRAIN HOMOGENATE; BRAIN ISCHEMIA; BRAIN PROTECTION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; LIPID PEROXIDATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MITOCHONDRION; NERVE CELL LESION; NONHUMAN; RAT; REPERFUSION INJURY; TRANSMISSION ELECTRON MICROSCOPY;

EID: 17144420087     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Koizumi JI, Yoshida Y, Nakazawa T et al. A new experimental model of cerebral embolism in rats in which recirculation can be introduced in the ischemia area[J]. Stroke, 1986, 8(1):1-8.
2. Longa EZ, Weinstein PR, Carlson S. Reversible middle cerebral artery occlusion without craniectomy in rats[J]. Stroke, 1989, 20 (1):84-91.
3. Piantadosi CA, Zhang J. Mitochondrial generation of reactive oxygen species after brain ischemia in the rat[J]. Stroke, 1996, 27 (2):327-32.
4. Chan PH. Role of oxidants in ischemic brain damage[J]. Stroke, 1996, 27(6):1124-9.
5. Barber DA, Hamis SR. oxygen free radicals and antioxidants: A review[J]. Am Pharm, 1994, 34(9):26-35.
6. Renolleau S, Aggoun-Zouaoui D, Ben-Ari Y. A model of transient unilateral focal ischemia with reperfusion in the P7 neonatal rat: Morphological changes indicative of apoptosis[J]. Stroke, 1998, 29 (7):1451-61.
7. Fiskum G, Murphy AN, Beal MF. Mitochondrial in neurodegeneration: Acute ischemia and chronic neurodegenerative diseases[J]. J Cereb Blood Flow Meta, 1999, 19(4):351-69.