Endoscopic variceal ligation plus propranolol versus endoscopic variceal ligation alone in primary prophylaxis of variceal bleeding

American Journal of Gastroenterology

Volumn 100, Issue 4, 2005, Pages 797-804

  Sarin, Shiv K ^a   Wadhawan, Manav ^a   Agarwal, Shriram R ^a   Tyagi, Pankaj ^a   Sharma, Barjesh C ^a  

^a G B PANT HOSPITAL   (India)

Author keywords

[No Author keywords available]

Indexed keywords

PROPRANOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ADULT; ARTICLE; CAUSE OF DEATH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE CALCULATION; DRUG WITHDRAWAL; DYSPNEA; ENDOSCOPIC SURGERY; ESOPHAGUS VARICES; FEMALE; FOLLOW UP; HEADACHE; HIGH RISK PATIENT; HUMAN; HYPOTENSION; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; PORTAL HYPERTENSION; POSTOPERATIVE COMPLICATION; PRIMARY PREVENTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SKIN ALLERGY; SURVIVAL; TREATMENT CONTRAINDICATION; TREATMENT OUTCOME; UPPER GASTROINTESTINAL BLEEDING; VEIN LIGATION; COMPARATIVE STUDY; ESOPHAGOSCOPY; GASTROINTESTINAL HEMORRHAGE; INDIA; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; PROSPECTIVE STUDY; RISK; SURVIVAL RATE;

ADRENERGIC BETA-ANTAGONISTS; ADULT; CAUSE OF DEATH; COMBINED MODALITY THERAPY; ESOPHAGEAL AND GASTRIC VARICES; ESOPHAGOSCOPY; FEMALE; FOLLOW-UP STUDIES; GASTROINTESTINAL HEMORRHAGE; HUMANS; INDIA; MALE; MIDDLE AGED; PROPRANOLOL; PROSPECTIVE STUDIES; RISK; SURVIVAL RATE;

EID: 17144419769     PISSN: 00029270     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1572-0241.2005.40468.x     Document Type: Article

References (37)

1. Garceau AJ, Chalmers TC. Boston interhospital liver group: Natural history of cirrhosis. Survival with esophageal varices. N Engl J Med 1963;268:469-73.
2. Lay CS, Tsai YT, Teg C, et al. Endoscopic variceal prophylaxis of first variceal bleeding in cirrhotic patients with high-risk esophageal varices. Hepatology 1997;25:1346-50.
3. D'Amico G, Pagliaro L, Bosch J. Pharmacological treatment of portal hypertension: An evidence-based approach. Semin Liver Dis 1999;19:475-505.
4. Pagliaro L, D'Amico G, Pasta L, et al. Portal hypertension in cirrhosis: Natural history. In: Bosch J and Groszmann RJ, eds. Portal hypertension. Pathophysiology and treatment. Oxford: Blackwell Scientific Publications, 1994:72-92.
5. Pagliaro L, D'Amico G, Sorenson TIA, et al. Prevention of first bleeding in cirrhosis. A meta-analysis of randomized clinical trials of non-surgical treatment. Ann Intern Med 1992;117:59-70.
6. Sarin SK, Guptan RK, Jain AK, et al. A randomized controlled trial of endoscopic variceal band ligation for primary prophylaxis of variceal bleeding. Eur J Gastroenterol Hepatol 1996;8:337-42.7.
7. North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices: Prediction of first variceal hemorrhage in patients with cirrhosis of liver and esophageal varices. N Engl J Med 1988;319:983.
8. Paquet KJ. Prophylactic endoscopic sclerosing treatment of the esophageal wall in varices: A prospective controlled trial. Endoscopy 1982;14:4.
9. Escorsell A, Bordas JM, Castaneda B, et al. Predictive value of variceal pressure response to continued pharmacological therapy in patients with cirrhosis and portal hypertension. Hepatology 2000;31:1061-7.
10. Navarro VJ, Garcia-Tsao G. Variceal hemorrhage. Crit Care Clin 1995;11:391.
11. Cales P, Zabotto B, Meskens C, et al. Gastroesophageal endoscopic features in cirrhosis: Observer variability, interassociations and relationship to hepatic dysfunction. Gastroenterology 1990;98:156.
12. Banares R, Albillos A, Rincon D, et al. Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: A meta-analysis. Hepatology 2002;35:609-15.
13. D'Amico G, Pagliaro L, Bosch J. The treatment of portal hypertension: A meta-analytic review. Hepatology 1995;22:332-54.
14. Sorbi D, Gostout CJ, Peura D, et al. An assessment of the management of acute bleeding varices: A multicenter prospective member-based study. Am J Gastroenterol 2003;98:2424-34.
15. Garcia-Tsao G, Grace ND, Groszmann RJ, et al. Short-term effects of propranolol on portal venous pressure. Hepatology 1986;6:101-6.
16. Merkel C, Bolognesi M, Sacerdoti D, et al. The hemodynamic response to medical treatment of portal hypertension as a predictor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosis. Hepatology 2000;32:930-4.
17. Sarin SK. Long term management of esophageal varices. Drugs 1992;44:(Suppl 2):56-69.
18. Lebrec D, Bernuau J, Rueff B, et al. Gastrointestinal bleeding after abrupt cessation of propranolol administration in cirrhosis. N Engl J Med 1982;307:560.
19. Abraczinkas DR, Ookubo RIE, Grace ND, et al. Propranolol for the prevention of first esophageal variceal hemorrhage: A lifetime commitment? Hepatology 2001;34: 1096-102.
20. Sarin SK, Lamba GS, Kumar M, et al. Comparison of endoscopic ligation and propranolol for the primary prevention of variceal bleeding. N Engl J Med 1999;340:988-93.
21. Lui HF, Stanley AJ, Forrest EH, et al. Primary prophylaxis of variceal hemorrhage: A randomized controlled trial comparing band ligation, propranolol and isosorbide mononitrate. Gastroenterology 2002;123:735-44.
22. Jensen DM. Endoscopic screening for varices in cirrhosis: Findings, implications and outcomes. Gastroenterology 2002;122:1620-30.
23. Imperiale TF, Chalasani N. A meta-analysis of endoscopic variceal ligation for primary prophylaxis of esophageal variceal bleeding. Hepatology 2001;33:802-7.
24. Sharara AI, Rockey DC. Therapy for primary prophylaxis of varices: And the winner is . . .? Hepatology 2003;37:473-5.
25. Conn HO. Ammonia tolerance in the diagnosis of esophageal varices: A comparison of the endoscopic, radiologic and biochemical techniques. J Lab Clin Med 1967;70:442-51.
26. Sarin SK, Sundaram KR, Ahuja RK. Predictors of variceal bleeding: An analysis of clinical, endoscopic and hemodynamic variables, with special reference to intravariceal pressure. Gut 1989;30:1757-64.
27. Sarin SK. Non-cirrhotic portal fibrosis. Gut 1989;30:406-15.
28. Sarin SK, Kapoor D. Non-cirrhotic portal fibrosis: Current concepts and management. J Gastroenterol Hepatol 2002;17:526-34.
29. Pugh RN, Murray-Lyon IM, Dawson JL, et al. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60:646-9.
30. Altman DG. Practical statistics for medical research. London: Chapman & Hall, 1991.
31. de Franchis R ed. Portal hypertension III. Proceedings of the third Baveno international consensus workshop on definitions, methodology and therapeutic strategies. Blackwell Science, 2001.
32. Sarin SK, Lahoti D, Saxena SP, et al. Prevalence, classification and natural history of gastric varices: A long-term follow-up study in 568 portal hypertension patients. Hepatology 1992;16:1343-9.
33. Bureau C, Peron JM, Alric L, et al. "A la carte" treatment of portal hypertension: Adapting medical therapy to hemodynamic response for the prevention of bleeding. Hepatology 2002;36:1361-6.
34. Abecasis R, Kravetz D, Fassio E, et al. Nadolol plus spironolactone in the prophylaxis of first variceal bleeding in nonascitic cirrhotic patients: A preliminary study. Hepatology 2003;37:359-65.
35. Poynard T, Calès P, Pasta L, et al. Beta-adrenergic antagonist drugs in the prevention of gastrointestinal bleeding in patients with cirrhosis and esophageal varices. N Engl J Med 1991;324:1532-8.
36. Pagliaro L, D'Amico G, Sorensen TIA, et al. Prevention of first bleeding in cirrhosis. A meta-analysis of randomized trials of nonsurgical treatment. Ann Intern Med 1992;117:59-70.
37. García-Pagán JC, Morillas R, Bañares R, et al. Propranolol plus placebo versus propranolol plus isosorbide-5-mononitrate in the prevention of a first variceal bleed: A double-blind RCT. Hepatology 2003;37:1260-6.