A novel in-silico approach for QSAR studies of anabolic and androgenic activities in the 17β-hydroxy-5α-androstane steroid family

QSAR and Combinatorial Science

Volumn 24, Issue 2, 2005, Pages 218-226

  Alvarez Ginarte, Yoanna María ^a,b   Crespo, Rachel ^b   Montero Cabrera, Luis Alberto ^b   Ruiz Garcia, José Alberto ^a   Ponce, Yovani Marrero ^d   Santana, Roberto ^c   Pardillo Fontdevila, Eladio ^a   Alonso Becerra, Esther ^b  

^a Center of Pharmaceutical Chemistry Cuba   (Cuba)

^b UNIVERSITY OF HAVANA   (Cuba)

^c INSTITUTO DE CIBERNÉTICA   (Cuba)

^d CENTRAL UNIVERSITY OF LAS VILLAS   (Cuba)

Author keywords

Genetic Algorithms; Levator ani muscle; Quantitative Structure Activity Relationship; Seminal vesicle; Ventral prostate

Indexed keywords

COMPUTATIONAL CHEMISTRY; ELECTRONIC PROPERTIES; MOLECULES; MUSCLE; UROLOGY;

ANDROGENIC ACTIVITY; ANDROSTANE; IN-SILICO; LEVATOR ANI MUSCLES; MOLECULAR DESCRIPTORS; QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP MODELING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP STUDIES; SEMINAL VESICLE; VENTRAL PROSTATE;

GENETIC ALGORITHMS;

1 METHYL 5ALPHA ANDROST 1 EN 17BETA OL 3 ONE 17 ACETATE; 17ALPHA METHYL 17BETA HYDROXY 5ALPHA ANDROST 1 EN 3 ONE; 17ALPHA METHYL 17BETA HYDROXY 5ALPHA ANDROST 2 EN 4 ONE; 17ALPHA METHYL 17BETA HYDROXY 5ALPHA ANDROST 2 ENE 2 CARBOXYLIC ACID; 17ALPHA METHYL 17BETA HYDROXY 5ALPHA ANDROST 2' METHYL[2,3 D]THIAZOLE; 17ALPHA METHYL 17BETA HYDROXY 5ALPHA ANDROSTANO[2,3 D] 2' METHYLPYRIMIDINE; 17ALPHA METHYL 17BETA HYDROXYANDROST 4 ENO[2,3 D]ISOXAZOLE; 17ALPHA METHYL 17BETA HYDROXYANDROSTA 3,5 DIENE; 17ALPHA METHYL 2 BROMO 17BETA HYDROXY 5ALPHA ANDROST 1 EN 3 ONE; 17ALPHA METHYL 5ALPHA 17BETA DIHYDROXYANDROST 2 ENE; 17ALPHA METHYL TESTOSTERONE 3 CYCLOPENTYL ENOL ETHER; 17ALPHA METHYLTESTOSTERONE 3 CYCLOHEXYL ENOL ETHER; 17BETA ACETOXY 5ALPHA ANDROSTA 1,3 DIENE; 17BETA ACETOXYANDROSTA 2,4 DIENE; 17BETA HYDROXY 5ALPHA ANDROSTANE DERIVATIVE; 17BETA HYDROXYANDROSTA 2,4 DIENE; 1ALPHA METHYL 17BETA HYDROXY 5ALPHA ANDROST 1 EN 3 ONE; 1ALPHA METHYL 17BETA HYDROXY 5ALPHA ANDROST 2 ENE; 1ALPHA,17ALPHA DIMETHYL 17BETA HYDROXY 5ALPHA ANDROSTANO[2,3 D]ISOXAZOLE; 2 ACETOXYMETHYLENE 17BETA HYDROXY 5ALPHA ANDROST 3 ENE; 2 CHLORO 17ALPHA METHYL 17BETA HYDROXY 5ALPHA ANDROST 1 EN 3 ONE; 2 CYANO 17ALPHA METHYL 17BETA ACETOXY 5ALPHA ANDROST 2 ENE; 2 FLUOROMETHYL 17BETA ACETOXY 5ALPHA ANDROST 2 ENE; 2 FORMYL 17ALPHA METHYL 17BETA HYDROXY 5ALPHA ANDROST 1 EN 3 ONE; 2 FORMYL 17BETA HYDROXY 17ALPHA METHYL 5ALPHA ANDROST 2 ENE; 2 METHYL 17BETA ACETOXY 5ALPHA ANDROST 1 EN 3 ONE; 2 METHYL 17BETA ACETOXY 5ALPHA ANDROST 1 ENE; 2,17 DIMETHYL 17ALPHA ACETOXY 5ALPHA ANDROST 2 ENE; 2ALPHA,17ALPHA DIMETHYL 17BETA HYDROXYANDROSTA 3,5 DIENE; 5ALPHA ANDROST 1 EN 17BETA OL; 5ALPHA ANDROST 3 EN 17BETA OL; 6BETA,17ALPHA DIMETHYL 17BETA HYDROXY 5ALPHA ANDROST 2 ENE; ANABOLIC AGENT; ANDROGEN; PLACEBO; STEROID; TESTOSTERONE 3 CYCLOPENTENYL ENOL ETHER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCULATION; CHEMICAL MODIFICATION; COMBINATORIAL CHEMISTRY; COMPUTER MODEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GENETIC ALGORITHM; HORMONE ACTION; HYDROPHOBICITY; LEVATOR ANI MUSCLE; LINEAR REGRESSION ANALYSIS; MALE; MOUSE; MUSCLE MASS; NONHUMAN; ORGAN WEIGHT; PHYSICAL CHEMISTRY; PREDICTION; PRIORITY JOURNAL; PROSTATE VENTRAL LOBE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; QUANTUM CHEMISTRY; TECHNIQUE;

EID: 17144418884     PISSN: 1611020X     EISSN: None     Source Type: Journal    
DOI: 10.1002/qsar.200430889     Document Type: Article

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