Torsades de pointes with methadone

Prescrire International

Volumn 14, Issue 76, 2005, Pages 61-62

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; ALCOHOL; ANTIARRHYTHMIC AGENT; ANTIDEPRESSANT AGENT; ANTIFUNGAL AGENT; ANTIRETROVIRUS AGENT; BENZODIAZEPINE; BUPRENORPHINE; CANNABIS; CIMETIDINE; CIPROFLOXACIN; COCAINE; CYTOCHROME P450 3A4; DIAMORPHINE; LAMIVUDINE; LEVACETYLMETHADOL; MACROLIDE; METHADONE; MORPHINE; MOXIFLOXACIN; NELFINAVIR; NEUROLEPTIC AGENT; OPIATE; OPIATE AGONIST; POTASSIUM; PYRROLE DERIVATIVE; SEROTONIN UPTAKE INHIBITOR; UNINDEXED DRUG; VALPROIC ACID; ZIDOVUDINE;

ALCOHOLISM; ARTICLE; ARTIFICIAL HEART PACEMAKER; BRADYCARDIA; CANNABIS ADDICTION; CHRONIC PAIN; COCAINE DEPENDENCE; DEFIBRILLATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; DOSE RESPONSE; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MEGADOSE; DRUG METABOLISM; DRUG OVERDOSE; DRUG SURVEILLANCE PROGRAM; DRUG WITHDRAWAL; ELECTROCARDIOGRAPHY; EPILEPSY; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HEPATITIS C; HEPATITIS C VIRUS; HEROIN DEPENDENCE; HUMAN; HYPOKALEMIA; OPIATE ADDICTION; PATIENT MONITORING; QT PROLONGATION; RESPIRATION DEPRESSION; RETROSPECTIVE STUDY; RISK ASSESSMENT; SYNCOPE; TORSADE DES POINTES;

ANALGESICS, OPIOID; ARYL HYDROCARBON HYDROXYLASES; DRUG INTERACTIONS; HEROIN; HUMANS; HYPOKALEMIA; LONG QT SYNDROME; METHADONE; NARCOTICS; OPIOID-RELATED DISORDERS; PAIN; RETROSPECTIVE STUDIES; RISK FACTORS; SWITZERLAND; TORSADES DE POINTES;

EID: 17144411801     PISSN: 11677422     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Prescrire Editorial Staff "Methadone" Prescrire Int 1996; 5 (21): 2-6.
2. "Methadone hydrochloride". In: "Martindale The complete drug reference" 34th ed, The Pharmaceutical Press, London 2005: 57-59.
3. Bittar P et al. "Methadone, induced long QTc and torsade de pointe" Forum Med Suisse 2002; suppl 8: 36.
4. Swissmedic "Méthadone et risque dose-dépendant de prolongation de l'intervalle QT et de torsades de pointes - Informations importantes pour les professionnels de la santé" 15 January 2004. Website http://www.swissmedic.ch consulted on 9 February 2004.
5. Walker PW et al. "High dose methadone and ventricular arrhythmias: a report of three cases" Pain 2003; 103: 321-324.
6. Gil M et al. "QT prolongation and torsades de pointes in patients infected with human immunodeficiency virus and treated with methadone" Am J Cardiol 2003; 92 (8): 995-997.
7. Krantz MJ et al. "Torsade de pointes associated with very-high-dose methadone" Ann Intern Med 2002; 137: 501-504 + 2003; 139 (4): W64.
8. Piguet V et al. "QT interval prolongation in patients on methadone with concomitant drugs" J Clin Psychopharmacol 2004; 24 (4): 446-448.
9. Krantz MJ et al. "Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes" Pharmacotherapy 2003; 23 (6): 802-805.
10. Mathot F et al. "Long QTc and psychotropic drugs use" Int J Neuropsychopharmacol 2000; 3 (suppl 1): P.02.18.
11. Prescrire Editorial Staff "Neuroleptics: severe ventricular arrhythmia and sudden death" Prescrire Int 2002; 11 (61): 146-150.
12. Martell BA et al. "The impact of methadone induction on cardiac conduction in opiate users" Ann Intern Med 2003; 139 (2): 154-155.
13. o: commercialisation repoussée en attendant une réévaluation" Rev Prescrire 2001; 21 (214): 117.
14. Lipski J et al. "The effect of heroin and multiple drug abuse on the electrocardiogram" Am Heart J 1973; 86 (5): 663-668.
15. Blair JR et al. "Prolongation of QT interval in association with the administration of large doses of opiates" Anesthesiology 1987; 67 (3): 442-443.
16. "Buprenorphine". In: "Martindale The complete drug reference" 34th ed, The Pharmaceutical Press, London 2005: 21-23.
17. US Food and Drug Administration "Suboxone - Subutex label" 10 September 2002. Website http://www.fda.org consulted on 3 March 2004.
18. "Méthadone Chlorhydrate Assistance publique-Hôpitaux de Paris". In French datasheet compendium: "Dictionnaire Vidal" Vidal, Issy-les-Moulineaux 2004: 1188-1189.
19. "General considerations and an outline survey of some basic interaction mechanisms". In: Stockley IH et al. "Drug interactions" 6th ed, The Pharmaceutical Press, London 2002: 1-14.
20. "Methadone + cimetidine", "Methadone + ciprofloxacin", "Methadone + fluconazole", "Methadone + protease inhibitors", "Methadone + selective serotonin re-uptake inhibitors (SSRIs)". In: Stockley IH et al. "Drug interactions" 6th ed, The Pharmaceutical Press, London 2002: 63-67.
21. De Bels D et al. "Torsades de pointes due to methadone" Ann Intern Med 2003; 139 (2): E156.