Trimetazidine in angina combination therapy - The TACT study: Trimetazidine versus conventional treatment in patients with stable angina pectoris in a randomized, placebo-controlled, multicenter study

American Journal of Therapeutics

Volumn 12, Issue 1, 2005, Pages 35-42

  Chazov, E I ^a   Lepakchin, V K ^a   Zharova, E A ^a   Fitilev, S B ^a   Levin, A M ^a   Rumiantzeva, E G ^a   Fitileva, T B ^a  

^a INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

Author keywords

Addictive effect; Combined therapy; Stable angina trimetazidine

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; NITRIC ACID DERIVATIVE; PLACEBO; TRIMETAZIDINE;

ADULT; AGED; ANGINA PECTORIS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG FATALITY; EXERCISE TEST; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NAUSEA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT DEPRESSION; STOMACH ULCER; STUDENT T TEST; TACHYCARDIA;

ADULT; AGED; ANGINA PECTORIS; BLOOD PRESSURE; DRUG THERAPY, COMBINATION; EXERCISE TEST; HEART RATE; HUMANS; MALE; MIDDLE AGED; TRIMETAZIDINE; VASODILATOR AGENTS;

EID: 17144397604     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/00045391-200501000-00006     Document Type: Article

References (21)

1. Jones DW, Sempos CT, Thom TJ, et al. Rising levels of cardiovascular mortality in Mississippi, 1979-1995. Am J Med Sci. 2000;319:131-137.
2. Thorn TJ, et al. Incidence, prevalence, and mortality of cardiovascular diseases in the United States. In: Alexander RW, Schlant RC, Fuster V, eds. Hurst's the Heart, 9th ed. New York: McGraw-Hill; 1998:3-17.
3. Task Force of the European Society of Cardiology. Management of stable angina. Eur Heart J. 1997;18:394-413.
4. ACC/AHA/ACP-ASIM Guidelines for the Management of Patients with Chronic Stable Angina. A Report of American College of Cardiology American Heart Association Task Force of Practice Guidelines (Committee on Management of patients With Chronic Stable Angina). J Am Coll Cardiol. 1999;33:2092-2197.
5. Dargie HJ, Ford I, Fox M, on behalf of the Total Ischaemic Burden European Trial (TIBET) Group. Effects of ischaemia and treatment with atenolol, nifedipine SR and their combination on outcome in patients with chronic stable angina. The TIBET Study Group. Eur Heart J. 1996;17:104-112.
6. Savanitto S, Ardissino D, Egstrup K, et al., on behalf of the International Multicenter AnGina Exercise (IMAGE) Study Group. Combination therapy with metoprolol and nifedipine versus monotherapy in patients with stable angina pectoris. J Am Coll Cardiol. 1996;27:311-316.
7. Ferguson JD, Ormerod O, Lenox-Smith AJ. Bisoprolol alone and in combination with amlodipine or nifedipine in the treatment of chronic stable angina. Int J Clin Pract. 2000;54:360-363.
8. Klein WW. Coron Art Dis. 2002;13:427-436.
9. Jackson G. Stable angina: maximal medical therapy is not the same as optimal medical therapy. Int J Clin Pract. 2000; 54:351.
10. Jackson G. Combination therapy in angina: a review of combined haemodynamic treatment and the role for combined haemodynamic and cardiac metabolic agents. Int J Clin Pract. 2001;55:256-261.
11. Kantor P, Lucien A, Kozak R, et al. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2000;86:580-588.
12. El Banani H, Bernard M, Baetz D, et al. Changes in intracellular sodium and pH during ischemia-reperfusion are attenuated by trimetazidine. Comparison between low- and zero-flow ischemia. Cardiovasc Res. 2000;47:688-696.
13. Sentex E, Sergiel JP, Lucien A, et al. Trimetazidine increases phospholipid turnover in ventricular myocyte. Mol Cell Biochem. 1997;175:153-162.
14. McClellan KJ, Plosker GL. Trimetazidine. A review of its use in stable angina pectoris and other coronary conditions. Drugs. 1999;58:143-157.
15. Stanley WC. Partial fatty acid oxidation inhibitors for stable angina. Expert Opin Investig Drugs. 2002;11:615-629.
16. Szwed H, Sadowski Z, Elikowski W, et al. Trimpol II: Combination treatment of stable effort angina using trimetazidine and metoprolol: results of a randomised, double blind, multicentre study. Eur Heart J. 2001;22:2267-2274.
17. Levy S. Combination therapy of trimetazidine with diltiazem in patients with coronary artery disease. Group of South of France Investigators. Am J Cardiol. 1995;76:12B-16B.
18. Michaelides AP, Spiropoulos K, Dimopoulos K, et al. Antianginal efficacy of the combination of trimetazidine-propranolol compared with isosorbide dinitratepropranolol in patients with stable angina. Clin Drug Investig. 1997;13:8-14.
19. Campeau L. Grading of angina pectoris (letter). Circulation. 1976;54:522-523.
20. Manchanda SC, Krishnaswani S. Combination treatment with trimetazidine and diltiazem in stable angina pectoris. Heart. 1997;78:353-357.
21. Brochier M, Demange J, Duclous G, et al. Intérêt thérapeutique de l'association de la trimétazidine avec un inhibiteur calcique dans le traitement de l'insuffisance coronarienne chronique. Presse Med. 1986;15:1783-1787.