Colon cancer: Molecular pathogenesis and clinical relevance;Kolonkarzinom: Molekulare pathogenese und klinische relevanz

Deutsche Medizinische Wochenschrift

Volumn 130, Issue 13, 2005, Pages 809-811

  Arnold, Christian N ^a   Blum, H E ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMAL INSTABILITY; CLINICAL FEATURE; COLON CARCINOMA; GENE MUTATION; MOLECULAR GENETICS; PATHOGENESIS; REVIEW;

ADENOMA; CHROMOSOMAL INSTABILITY; COLONIC NEOPLASMS; CPG ISLANDS; DNA METHYLATION; GENETIC SCREENING; HUMANS; MICROSATELLITE REPEATS; PHENOTYPE; PROGNOSIS;

EID: 17144384836     PISSN: 00120472     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-865093     Document Type: Review

References (5)

1. Arnold C, Usadel H, Blum HE. Epigenetics: significance for tumor genesis and clinical features. Dtsch Med Wochenschr 2002; 127: 1701-1703
2. Goel A, Arnold CN, Niedzwiecki D et al. Characterization of sporadic colon cancer by patterns of genomic instability. Cancer Res 2003; 63: 1608-1614
3. Ionov Y, Peinado MA, Malkhosyan S et al. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993; 363: 558-561
4. Toyota M, Ahuja N, Ohe-Toyota M et al. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci USA 1999; 96: 8681-8686
5. Vogelstein B, Fearon ER, Hamilton SR et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988; 319: 525-532