Structural requirements for inhibitors of cytochromes P450 2B: Assessment of the enzyme interaction with diamondoids

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 20, Issue 1, 2005, Pages 25-33

  Hodek, Petr ^a   Bořek Dohalská, Lucie ^a   Sopko, Bruno ^a   Šulc, Miroslav ^a   Smrček, Stanislav ^a   Hudeček, Jiří ^a   Janků, Josef ^b   Stiborová, Marie ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF CHEMICAL TECHNOLOGY   (Czech Republic)

Author keywords

CYP2B4; Cytochrome P450 2B; Diamondoid compound; Enzyme inhibition; Homology model; Substrate binding

Indexed keywords

2 ISOPROPENYL 2 METHYLADAMANTANE; 3 ISOPROPENYL 3 METHYLDIAMANTANE; ADAMANTANE; ADAMANTANE DERIVATIVE; CONGRESSANE; CYTOCHROME P450 2B; CYTOCHROME P450 INHIBITOR; TRIAMANTANE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CALCULATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; GENE SEQUENCE; HYDROPHOBICITY; MALE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS;

ADAMANTANE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; CYTOCHROME P-450 CYP2B1; ENZYME INHIBITORS; HYDROPHOBICITY; MALE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RABBITS; RATS; RATS, WISTAR;

EID: 17144383651     PISSN: 14756366     EISSN: None     Source Type: Journal    
DOI: 10.1080/14756360400024324     Document Type: Article

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