No evidence for production of intrathecal immunoglobulin G against Acinetobacter or Pseudomonas in multiple sclerosis

European Neurology

Volumn 53, Issue 1, 2005, Pages 27-31

  Chapman, Miles D ^a   Hughes, Lucy E ^a   Wilson, Clyde D ^a   Namnyak, Simon ^a   Thompson, Edward J ^a   Giovannoni, Gavin ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Acinetobacter; Affinity; Intrathecal synthesis; Multiple sclerosis; Oligoclonal IgG; Pseudomonas

Indexed keywords

BACTERIUM ANTIBODY; IMMUNOGLOBULIN G;

ACINETOBACTER CALCOACETICUS; ADULT; ANTIBODY AFFINITY; ANTIBODY DETECTION; ARTICLE; BINDING AFFINITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOGLOBULIN PRODUCTION; INTERMETHOD COMPARISON; MALE; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

ACINETOBACTER; ADULT; CASE-CONTROL STUDIES; FEMALE; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PSEUDOMONAS;

EID: 17144367729     PISSN: 00143022     EISSN: None     Source Type: Journal    
DOI: 10.1159/000083715     Document Type: Article

References (17)

1. Rosati G: The prevalence of multiple sclerosis in the world: An update. Neurol Sci 2001;22:117-139.
2. Granieri E, Casetta I, Tola MR, Ferrante P: Multiple sclerosis: Infectious hypothesis. Neurol Sci 2001;22:179-185.
3. Challoner PB, Smith KT, Parker JT, MacLeod DL, Coulter SN, Rose TM, Schultz ER, Lindsley Bennett J, Garber RL, Ming Chang, Schad PA, Stewart PM, Nowinski RC, Brown JP, Burmer GC: Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Nat Acad Sci 1995;92:7440-7444.
4. Sriram S, Stratton CW, Yao S, Tharp A, Ding L, Bannan JD, Mitchell WM: Chlamydia pneumoniae infection of the central nervous system in multiple sclerosis. Ann Neurol 1999;46:6-14.
5. Vartdal F, Vandvik B, Norrby E: Viral and bacterial antibody responses in multiple sclerosis. Ann Neurol 1980;8:248-255.
6. Talbot PJ, Arnold D, Antel JP: Virus-induced autoimmune reactions in the CNS. Curr Top Microbiol Immunol 2001;253:247-271.
7. Steiner I, Nisipianu P, Wirguin I: Infection and the etiology and pathogenesis of multiple sclerosis. Curr Neurol Neurosci Rep 2001;1:271-276.
8. Albert LT, Inman RD: Molecular mimicry and autoimmunity. NEJM 1999;341:2068-2074.
9. Wucherpfennig KW, Strominger JL: Molecular mimicry in T cell mediated autoimmunity: Viral peptides activate human T cell clones. Cell 1995;80:695-705.
10. Eylar EH, Caccam J, Jackson JJ: Experimental allergic encephalomyelitis: Synthesis of disease-inducing site of the basic protein. Science 1970;168:1220-1223.
11. Hughes LE, Bonell S, Natt RS, Wilson C, Tiwana H, Ebringer A, Cunningham P, Chamoun V, Thompson EJ, Croker J, Vowles J: Antibody responses to Acinetobacter spp. and Pseudomonas aeruginosa in multiple sclerosis: Prospects for diagnosis using the myelin-Acinetobacter-neurofilament antibody index. Clin Diagn Lab Immunol 2001;8:1181-1188.
12. Moyle S, Keir G, Thompson EJ: Viral immunoblotting: A sensitive method for detecting viral-specific oligoclonal bands in unconcentrated cerebrospinal fluid. Biosci Rep 1984;4:505-510.
13. Andersson M, Alvarez-Cermeno J, Bernardi G, Cogato I, Fredman P, Frederiksen J, Frederikson S, Gallo P, Grimaldi LM, Gronning M, Keir G, Lamers K, Link H, Magalhaes A, Massaro AR, Ohman S, Reiber H, Ronnback L, Schluep M, Schuller E, Sindic CJM, Thompson EJ, Trojano M, Wurster U: Cerebrospinal fluid in the diagnosis of multiple sclerosis: A consensus report. JNNP 1994;57:897-902.
14. Keir G, Luxton RW, Thompson EJ: Isoelectric focusing of cerebrospinal fluid IgG: An annotated update. Ann Clin Biochem 1990;27:436-443.
15. Luxton RW, Zeman A, Holzel H, Harvey P, Wilson J, Kocen R, Morgan-Hughes J, Miller DH, Compston A, Thompson EJ: Affinity of antigen-specific IgG distinguishes multiple sclerosis from encephalitis. J Neurol Sci 1995;132:11-19.
16. Bouvet J-P. Stahl D, Rose S, Quan CP, Kazatchkine MD, Kaveri SV: Induction of natural autoantibody activity following treatment of human immunoglobulin with dissociating agents. J Autoimmun 2001;16:163-172.
17. Mazza G, Ponsford M, Lowrey P, Campbell MJ, Zajicek J, Wraith DC: Diversity and dynamics of the T-cell response to MBP in DR2+ve individuals. Clin Exp Immunol 2002; 128:538-547.