The effects of urethritis on seminal plasma HIV-1 RNA loads in homosexual men not receiving antiretroviral therapy

Sexually Transmitted Infections

Volumn 81, Issue 2, 2005, Pages 120-123

  Sadiq, S T ^a,b   Taylor, S ^c   Copas, A J ^b   Bennett, J ^b   Kaye, S ^b   Drake, S M ^c   Kirk, S ^b   Pillay, D ^b   Weller, I V D ^b  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; VIRUS RNA;

ADULT; AFRICA SOUTH OF THE SAHARA; ANTIBIOTIC THERAPY; ARTICLE; CASE CONTROL STUDY; CHLAMYDIA; CLINICAL ARTICLE; CONTROLLED STUDY; DEVELOPED COUNTRY; GONOCOCCAL URETHRITIS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HOMOSEXUALITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUANTITATIVE ANALYSIS; SEMEN ANALYSIS; SYMPTOMATOLOGY; URETHRITIS; VIRUS INFECTIVITY; VIRUS LOAD;

ADULT; CASE-CONTROL STUDIES; CHLAMYDIA INFECTIONS; FEMALE; FOLLOW-UP STUDIES; GONORRHEA; HIV-1; HOMOSEXUALITY, MALE; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RNA, VIRAL; SEMEN; URETHRITIS; VIRAL LOAD;

EID: 17144366208     PISSN: 13684973     EISSN: None     Source Type: Journal    
DOI: 10.1136/sti.2004.010249     Document Type: Article

References (30)

1. De Vincenzi I. A longitudinal study of human immunodeficiency virus transmission by heterosexual partners. European Study Group on Heterosexual Transmission of HIV. N Engl J Med 1994;331:341-6.
2. Lee TH, Sakahara N, Fiebig E, et al. Correlation of HIV-1 RNA levels in plasma and heterosexual transmission of HIV-1 from infected transfusion recipients. J Acquir Immune Defic Syndr Human Retrovir 1990;12:427-8.
3. Quinn TC, Wawer MJ, Sewankambo N, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. Rakai Project Study Group. N Engl J Med 2000;342:921-9.
4. Coombs RW, Speck CE, Hughes JP, et al. Association between culturable human immunodeficiency virus type 1 (HIV-1) in semen and HIV-1 RNA levels in semen and blood: evidence for compartmentalization of HIV-1 between semen and blood. J Infect Dis 1998;177:320-30.
5. Tachet A, Dulioust E, Salmon D, et al. Detection and quantification of HlV-1 in semen: identification of a subpopulation of men at high potential risk of viral sexual transmission. AIDS 1999;13:823-31.
6. Fiscus SA, Vernazza PL, Gilliam B, et al. Factors associated with changes in HIV shedding in semen. AIDS Res Human Retrovir 1998;14(Suppl 1):S27-S31.
7. Vernazza PL, Gilliam BL, Dyer J, et al. Quantification of HIV in semen: correlation with antiviral treatment and immune status. AIDS 1997;11:987-93.
8. Xu C, Politch JA, Tucker L, et al. Factors associated with increased levels of human immunodeficiency virus type 1 DNA in semen. J Infect Dis 1997;176:941-947.
9. Sadiq ST, Taylor S, Kaye S, et al. The effects of antiretroviral therapy on HIV-1 RNA loads in seminal plasma in HIV-positive patients with and without urethritis. AIDS 2002;16:219-25.
10. Cohen MS, Hoffman IF, Royce RA, et al. Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1. AIDSCAP Malawi Research Group. Lancet 1997;349:1868-73.
11. Moss GB, Overbaugh J, Welch M, et al. Human immunodeficiency virus DNA in urethral secretions in men: association with gonococcal urethritis and CD4 cell depletion. J Infect Dis 1995;172:1469-74.
12. Eron JJ Jr, Gilliam B, Fiscus S, et al. HIV-1 shedding and chlamydial urethritis. JAMA 1996;275:36.
13. Winter AJ, Taylor S, Workman J, et al. Asymptomatic urethritis and detection of HIV-1 RNA in seminal plasma. Sex Transm Infect 1999;75:261-3.
14. Dyer JR, Kazembe P, Vernazza PL, et al. High levels of human immunodeficiency virus type 1 in blood and semen of seropositive men in sub-Saharan Africa. J infect Dis 1998;177:1742-6.
15. Clerici M, Butto S, Lukwiya M, et al. Immune activation in africa is environmentally-driven and is associated with upregulation of CCR5. Italian-Ugandan AIDS Project. AIDS 2000;14:2083-92.
16. Montana MA, Nixon CP, Ndung'u T, et al. Elevated tumor necrosis factor-alpha activation of human immunodeficiency virus type 1 subtype C in Southern Africa is associated with an NF-kappaB enhancer gain-of-function. J Infect Dis 2000;181:76-81.
17. Faxelid E, Ahlberg BM, Ndulo J, et al. Health-seeking behaviour of patients with sexually transmitted diseases in Zambia. East Afr Med J 1998;75:232-6.
18. Smith R, Copas A, Prince M, et al. Poor sensitivity and consistency of microscopy in the diagnosis of low grade non-gonococcal urethritis. Sex Transm Infect 2003;79:487-90.
19. Boom R, Sol CJ, Salimans MM, et al. Rapid and simple method for purification of nucleic acids. J Clin Microbiol 1990;28:495-503.
20. Atkins MC, Carlin EM, Emery VC, et al. Fluctuations of HIV load in semen of HIV positive patients with newly acquired sexually transmitted diseases. BMJ 1996;313:341-2.
21. Zhu T, Wang N, Carr A, et al. Genetic characterization of human immunodeficiency virus type 1 in blood and genital secretions: evidence for viral compartmentalization and selection during sexual transmission. J Virol 1996;70:3098-107.
22. Ball JK, Curran R, Irving WL, et al. HIV-1 in semen: determination of proviral and viral titres compared to blood, and quantification of semen leukocyte populations. J Med Virol 1999;59:356-63.
23. Paranjpe S, Craigo J, Patterson B, et al. Subcompartmentalization of HIV-1 quasispecies between seminal cells and seminal plasma indicates their origin in distinct genital tissues. AIDS Res Human Retrovir 2002;18:1271-80.
24. Ping LH, Cohen MS, Hoffman I, et al. Effects of genital tract inflammation on human immunodeficiency virus type 1 V3 populations in blood and semen. J Virol 2000;74:8946-52.
25. Chakraborty H, Sen PK, Helms RW, et al. Viral burden in genital secretions determines male-to-female sexual transmission of HIV-1: a probabilistic empiric model. AIDS 2001;15:621-7.
26. Varela JA, Otero L, Garcia MJ, et al. Trends in the prevalence of pathogens causing urethritis in Asturias, Spain, 1989-2000. Sex Transm Dis 2003;30:280-3.
27. Benn P, Rooney G, Brown M, et al. The performance of the ligase chain reaction (LCR) in determining the prevalence of pharyngeal, urethral and rectal Chlamydia trachomatis and Neisseria gonorrhoeae in homosexual men. Berlin: ISSTDR, 2001.
28. Hobbs MM, Kazembe P, Reed AW, et al. Trichomonas vaginalis as a cause of urethritis in Malawian men. Sex Transm Dis 1999;26:381-7.
29. Wendel KA, Erbelding EJ, Gaydos CA, et al. Use of urine polymerase chain reaction to define the prevalence and clinical presentation of Trichomonas vaginalis in men attending an STD clinic. Sex Transm Dis 2003;79:151-3.
30. Taylor S, Sadiq ST, Weller I, et al. Drug-resistant HIV-1 in the semen of men receiving antiretroviral therapy with acute sexually transmitted infections. Antivir Ther 2003;8:479-83.