Pharmacology and toxicology of a new aqueous formulation of intravenous amiodarone (amio-aqueous) compared with Cordarone IV

American Journal of Therapeutics

Volumn 12, Issue 1, 2005, Pages 9-16

  Somberg, John C ^a,b,d   Cao, Wei ^c   Cvetanovic, Ivana ^a,b   Ranade, Vasant ^c   Molnar, Janos ^c  

^a RUSH UNIVERSITY   (United States)

^b American Institute of Therapeutics   (United States)

^c Academic Pharmaceutical Inc   (United States)

^d NONE   (United States)

Author keywords

Intravenous amiodarone; Nonclinical pharmacology; Toxicology

Indexed keywords

AMIO AQUEOUS; AMIODARONE; BENZYL ALCOHOL; CORDARONE IV; DRUG SOLVENT; POLYSORBATE 80;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; AQUEOUS SOLUTION; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; HEART MUSCLE CONTRACTILITY; HYPOTENSION; INOTROPISM; LD 50; NONHUMAN; PRIORITY JOURNAL; RAT;

AMIODARONE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BLOOD PRESSURE; CHEMISTRY, PHARMACEUTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOTENSION; INFUSIONS, INTRAVENOUS; LETHAL DOSE 50; MYOCARDIAL CONTRACTION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 17144364342     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/00045391-200501000-00003     Document Type: Article

References (34)

1. Schutzenberger W, Leisch F, Kerschner K, et al. Clinical efficacy of intravenous amiodarone in the short term treatment of recurrent sustained ventricular tachycardia and ventricular fibrillation. Br Heart J. 1989;62:367-371.
2. Mooss AN, Mohiuddin SM, Hee TT, et al. Efficacy and tolerance of high-dose intravenous amiodarone for recurrent, refractory ventricular tachycardia. Am J Cardiol. 1990;65:609-614.
3. Nalos PC, Ismail Y, Pappas JM, et al. Intravenous amiodarone for short-term treatment of refractory ventricular tachycardia or fibrillation. Am Heart J. 1991;122: 1629-1632.
4. Ochi RP, Goldenberg IF, Almquist A, et al. Intravenous amiodarone for the rapid treatment of life-threatening ventricular arrhythmias in critically ill patients with coronary artery disease. Am J Cardiol. 1989;64:599-603.
5. Figa FH, Gow RM, Hamilton RM, et al. Clinical efficacy and safety of intravenous amiodarone in infants and children. Am J Cardiol. 1994;74:573-577.
6. Helmy I, Herre JM, Gee G, et al. Use of intravenous amiodarone for emergency treatment of life-threatening ventricular arrhythmias. J Am Coll Cardiol. 1988;12:1015-1022.
7. Klein RC, Machell C, Rushforth N, et al. Efficacy of intravenous amiodarone as short-term treatment for refractory ventricular tachycardia. Am Heart J. 1988;115: 96-101.
8. Leak D. Intravenous amiodarone in the treatment of refractory life-threatening cardiac arrhythmias in the critically ill patient. Am Heart J. 1986;111:456-462.
9. Somberg JC, Tepper D, Keefe DL. Incessant VT treated with IV amiodarone: rapid onset of action with a long half-life agent [abstract]. J Clin Pharmacol. 1986;26:543.
10. Morady F, Scheinman MM, Shen E, et al. Intravenous amiodarone in the acute treatment of recurrent symptomatic ventricular tachycardia. Am J Cardiol. 1983;51: 156-159.
11. Horowitz LN, Mattleman SJ, Spielman SR, et al. Intravenous amiodarone loading for ventricular tachycardia [abstract]. Circulation. 1982;66(suppl II):II-222.
12. Kudenchuk PJ, Cobb LA, Copass MK, et al. Amiodarone for resuscitation after out-of-hospital cardiac arrest due to ventricular fibrillation. N Engl J Med. 1999;341:871-878.
13. Dorian P, Cass D, Schwartz B, et al. Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation. N Engl J Med. 2002;346:884-890.
14. Somberg JC, Bailin SJ, Haffajee CI, et al. Intravenous lidocaine versus intravenous amiodarone (in a new aqueous formulation) for incessant ventricular tachycardia. Am J Cardiol. 2002;90:853-859.
15. Installe E, Schoevaerdts JC, Gadisseux P, et al. Intravenous amiodarone in the treatment of various arrhythmias following cardiac operations. J Thorac Cardiovasc Surg. 1981;81:302-308.
16. Kosinski EJ, Albin JB, Young E, et al. Hemodynamic effects of intravenous amiodarone. J Am Coll Cardiol. 1984; 4:565-570.
17. Levine JH, Massumi A, Scheinman MM, et al. Intravenous amiodarone for recurrent sustained hypotensive ventricular tachyarrhythmias. Intravenous Amiodarone Multicenter Trial Group. J Am Coll Cardiol. 1996;27:67-75.
18. Scheinman MM, Levine JH, Cannom DS, et al. Dose-ranging study of intravenous amiodarone in patients with life-threatening ventricular tachyarrhythmias. The Intravenous Amiodarone Multicenter Investigators Group. Circulation. 1995;92:3264-3272.
19. Kowey PR, Levine JH, Herre JM, et al. Randomized, double-blind comparison of intravenous amiodarone and bretylium in the treatment of patients with recurrent, hemodynamically destabilizing ventricular tachycardia or fibrillation. The Intravenous Amiodarone Multicenter Investigators Group. Circulation. 1995;92:3255-3263.
20. Cordarone intravenous drug specific package insert. In: Physicians' desk reference, 57th ed. Montvale, NJ: Thomson PDR; 2003;3387-3390.
21. Gough WB, Zeiler RH, Barreca P, et al. Hypotensive action of commercial intravenous amiodarone and polysorbate 80 in dogs. J Cardiovasc Pharmacol. 1982;4:375-380.
22. Platou ES, Refsum H. Acute electrophysiologic and blood pressure effects of amiodarone and its solvent in the dog. Acta Pharmacol Toxicol (Copenh). 1986;58:163-168.
23. Munoz A, Karila P, Gallay P, et al. A randomized hemodynamic comparison of intravenous amiodarone with and without Tween 80. Eur Heart J. 1988;9:142-148.
24. Sicart M, Besse P, Choussat A, et al. Hemodynamic effects of intravenous amiodarone in humans [in French]. Arch Mal Coeur Vaiss. 1977;70:219-227.
25. Yasaka WJ, Eichbaum FW, Oga S. Antiarrhythmic effects of solvents: III. Effects of propylene glycol and benzyl alcohol on contractile force of isolated rabbit heart. Cardiovasc Res. 1979;13:717-722.
26. Gruber CM. The pharmacology of benzyl alcohol and its esters. II. Some of the effects of benzyl alcohol, benzyl benzoate and benzyl acetate when injected intravenously upon the respiratory and circulatory systems. J Lab Clin Med. 1923;9:92.
27. Torres-Arraut E, Singh S, Pickoff AS. Electrophysiologic effects of Tween 80 in the myocardium and specialized conduction system of the canine heart. J Electrocardiol. 1984;17:145-151.
28. Path GJ, Dai XZ, Schwartz JS, et al. Effects of amiodarone with and without polysorbate 80 on myocardial oxygen consumption and coronary blood flow during treadmill exercise in the dog. J Cardiovasc Pharmacol. 1991;18:11-16.
29. Bellotti G, Suva LA, Esteves Filho A, et al. Hemodynamic effects of intravenous administration of amiodarone in congestive heart failure from chronic Chagas' disease. Am J Cardiol. 1983;52:1046-1049.
30. Somberg JC, Cvetanovic I, Ranade V, et al. Comparative effects of rapid bolus administration of aqueous amiodarone versus 10-minute Cordarone I.V. infusion on mean arterial blood pressure in conscious dogs. Circulation. 2003;108(suppl IV):IV-420.
31. Remme WJ, van Hoogenhuyze DC, Kruyssen DA, et al. Amiodarone. Haemodynamic profile during intravenous administration and effect on pacing-induced ischaemia in man. Drugs. 1985;29(suppl 3):11-22.
32. Remme WJ, Kruyssen HA, Look MP, et al. Hemodynamic effects and tolerability of intravenous amiodarone in patients with impaired left ventricular function. Am Heart J. 1991;122:96-103.
33. Gallik DM, Singer I, Meissner MD, et al. Hemodynamic and surface electrocardiographic effects of a new aqueous formulation of intravenous amiodarone. Am J Cardiol. 2002;90:964-968.
34. Somberg JC, Timar S, Bailin SJ, et al. and the Amio-Aqueous® Investigators. The lack of a hypotensive effect with rapid administration of a new aqueous formulation of intravenous amiodarone. Am J Cardiol. 2004;93, in press.