Synthesis and characterization of self-catalyzed poly(ortho ester)

Biomaterials

Volumn 19, Issue 7-9, 1998, Pages 791-800

  Sintzel, Martina B ^a   Heller, Jorge ^b   Ng, Steve Y ^b   Taylor, Michelle S ^b   Tabatabay, Cyrus ^a   Gurny, Robert ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b Advanced Polymer Systems   (United States)

Author keywords

Bioerodible polymer; Characterization; Control of the erosion; Hydrolysis; Self catalyzed poly(ortho ester); Synthesis

Indexed keywords

BIODEGRADATION; BIOSYNTHESIS; CATALYSIS; CHEMICAL BONDS; GLASS TRANSITION; HYDROLYSIS; INORGANIC ACIDS; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PH; POLYESTERS; RHEOLOGY;

HYDROPHOBICITY; HYDROXY ACID;

BIOMATERIALS;

DIMER; FLUOROURACIL; HYDROXYACID; POLY(ORTHO ESTER); POLYOL;

ARTICLE; CHEMICAL BOND; CHEMICAL STRUCTURE; DRUG DELIVERY SYSTEM; FILTERING OPERATION; GLAUCOMA; HYDROLYSIS; HYDROPHOBICITY; INFRARED SPECTROSCOPY; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE; PH; PRIORITY JOURNAL; PROTON TRANSPORT; SYNTHESIS;

ANTINEOPLASTIC AGENTS; BIOCOMPATIBLE MATERIALS; CATALYSIS; DRUG CARRIERS; FLUOROURACIL; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR WEIGHT; POLYESTERS; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; VISCOSITY;

EID: 17044450584     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0142-9612(97)00229-9     Document Type: Article

References (22)

1. [1] Heller J. POE (ortho esters). J Adv Pol Sci 1993;41:92-107.
2. [2] Ng SY, Vandamme T, Taylor MS, Heller J. Synthesis and erosion studies of self-catalyzed poly(ortho esters). Macromolecules 1997; 30:770-2.
3. [3] Heller J, Penhale DW, Helwing RF. Preparation of poly(ortho esters) by the reaction of diketene acetals and polyols. J Polym Sci 1980;18:619-24.
4. [4] Ng SY, Penhale DW, Heller J. Preparation of ketene acetals. U.S. Patent 4,513,143, 1985.
5. [5] Kolb, B. Multiple headspace extraction - a procedure for eliminating the influence of the sample matrix in quantitative headspace gas chromatography. Chromatographia 1982;15(9):587-94.
6. [6] Guimbard JP, Besson J, Beaufort S, Pittie J, Gachon M. Evaluation des solvants résiduels. STP Pharma Prat 1991;1:272-7.
7. [7] Heller J, Fritzinger BK, Ng SY, Penhale DW. In vitro and in vivo release of levonorgestrel from poly(ortho esters), I. Linear polymers. J Controlled Release 1985;1:225-32.
8. [8] Heller J, Penhale DW, Fritzinger BK, Rose JE, Helwing RF. Controlled release of contraceptive steroids from biodegradable poly(ortho esters). Contracept Deliv Syst 1983;4:43-53.
9. [9] Heller J, Rime A-F, Rao SS, Fritzinger, BK. Poly(ortho esters) for pulsed and continuous release of proteins. In: Lee VHL, Hashida M, Mizushima Y, editors. Trends and future perspectives in peptide and protein drug delivery. Chur Switzerland: Harwood Academic Publishers, 1995:39-56.
10. [10] Merkli A, Heller J, Tabatabay C, Gurny R. Semi-solid hydrophobic bioerodible poly(ortho ester) for potential application in glaucoma filtering surgery. J Controlled Release 1994;29:105-12.
11. [11] Ferry JD, editor. The viscoelastic behavior. In: Viscoelastic properties of polymer, 3rd ed. New York: Wiley, 1980.
12. [12] Davis SS. Viscoelastic properties of pharmaceutical semisolids III: nondestructive oscillatory testing. J Pharm Sci 1991; 60:1351-6.
13. [13] Barry BW, Meyer MC. The rheological properties of carbopol gels II. Oscillatory properties of carbopol gels. Int J Pharm 1979; 2:27-40.
14. [14] Lovel PA. Dilute solution viscometry. In: Booth C, Price C, editors. Comprehensive polymer science: the synthesis, characterization, reactions and applications of polymers Oxford: Pergamon Press, 1989;173-97.
15. [15] Sintzel MB, Merkli A, Heller J, Tabatabay C, Gurny R. Synthesis and analysis of viscous poly(ortho ester) analogs for controlled drug release. Int J Pharm 1997;155:253-69.
16. [16] Erni F, Helboe P, Artiges A. ICH guideline - residual solvents. Pharmeuropa 1996;8:109-11.
17. [17] Wigman LS, Zhang X, Fisher DO, Walinsky SW. ICH guideline: harmonization of residual solvents in pharmaceuticals. Pharm Technol 1996;20:102-8.
18. [18] Igarashi T. ICH guideline for residual solvents. Step 2 Draft 1996.
19. [19] Heller J, Ng SY, Penhale DW, Fritzinger BK, Sanders LM, Burns RA, Gaynon G, Bhosale SS. Use of poly(ortho esters) for the controlled release of 5-fluorouracyl and a LHRH analogue. J Controlled Release 1987;6:217-24.
20. [20] Göpferich A. Mechanisms of polymer degradation and erosion. Biomaterials 1996;17:103-14.
21. [21] Park K, Shalaby WSW, Park H, editors. Biodegradable hydrogels for drug delivery. Lancaster: Technomic Publishing Co. Inc., 1993.
22. [22] Zignani M, Merkli A, Sintzel MB, Bernatchez SF, Kloeti W, Heller J, Tabatabay C, Gurny, R. New generation of poly(ortho ester): synthesis, characterization, kinetics, sterilization and biocompatibility. J Controlled Release 1997;48:115-21.