Effect of cytogenin, a novel immunomodulator, on streptozotocin-induced diabetes in mice

Journal of Antibiotics

Volumn 58, Issue 3, 2005, Pages 202-205

  Kumagai, Hiroyuki ^a   Wakazono, Kuniko ^b   Agata, Naoki ^b   Isshiki, Kunio ^b   Ishizuka, Masaaki ^a   Ikeda, Daishiro ^a  

^a Numazu Bio Medical Research Institute   (Japan)

^b MERCIAN CORPORATION   (Japan)

Author keywords

Cytogenin; Diabetes; Inducible nitric oxide; Interleukin 6; Macrophage; Nitric oxide; Streptozotocin

Indexed keywords

CYTOGENIN; GAMMA INTERFERON; GLUCOSE; IMMUNOMODULATING AGENT; INTERLEUKIN 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PANCREAS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOZOCIN DIABETES; WEIGHT REDUCTION;

EID: 17044433153     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2005.24     Document Type: Article

References (15)

1. Kumagai H, Masuda T, Osono M, Hattori S, Naganawa H, Sawa T, Hamada M, Ishizuka M, Takeuchi T. Cytogenin, a novel antitumor substance. J Antibiot 43: 1505-1507 (1990)
2. Kumagai H, Masuda T, Ishizuka M, Takeuchi T. Antitumor activity of cytogenin. J Antibiot 48: 175-178 (1995)
3. Kumagai H, Osono M, Iijima M, Sakashita M, Ishizuka M, Takeuchi T. Action of cytogenin on lymphoid cells and their cytokine production. J Antibiot 48: 317-320 (1995)
4. Kumagai H, Masuda T, Sakashita M, Ishizuka M, Takeuchi T. Modulation of macrophage activity on tumor bearing mice by cytogenin. J Antibiot 48: 321-325 (1995)
5. Hirano S, Wakazono K, Agata N, Mase T, Yamamoto R, Matsufuji M, Sakata N, Iguchi H, Tone H, Ishizuka M, Takeuchi T, Abe C. Effects of cytogenin, a novel anti-arthritic agent, on type II collagen-induced arthritis in DBA/1J mice and adjuvant arthritis in Lewis rats. Int J Tissue React 16: 155-162 (1994)
6. Abe C, Hirano S, Wakazono K, Mase T, Yamamoto R, Matsufuji M, Sakata N, Agata N, Iguchi H, Ishizuka M, et al. Effects of cytogenin on spontaneous arthritis in MRL/1 mice and on pristane-induced arthritis (PIA) in DBA/1J mice. Int J Tissue React 17: 175-180 (1995)
7. Nakamura M, Nagafuchi S, Yamaguchi K, Takaki R. The role of thymic immunity and insulitis in the development of streptozocin-induced diabetes in mice. Diabetes 33: 894-900 (1984)
8. Keller R, Keist R. Abilities of activated macrophages to manifest tumoricidal activity and to generate reactive nitrogen intermediates: a comparative study in vitro and ex vivo. Biochem Biophys Res Commun 164: 968-973 (1989)
9. Roth SI, Conaway HH, Sanders LL, Casali RE, Boyd AE. Spontaneous diabetes mellitus in the New Zealand white rabbit: preliminary morphologic characterization. Lab Invest 42: 571-579 (1980)
10. Sadelain MW, Qin HY, Lauzon J, Singh B. Prevention of type I diabetes in NOD mice by adjuvant immunotherapy. 39: 583-589 (1990)
11. Darville MI, Eizirik DL. Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. Diabetologia 41: 1101-1108 (1998)
12. Flodstrom M, Tyrberg B, Eizirik DL, Sandler S. Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes. Diabetes 48: 706-713 (1999)
13. Kato Y, Miura Y, Yamamoto N, Ozaki N, Oiso Y. Suppressive effects of a selective inducible nitric oxide synthase (iNOS) inhibitor on pancreatic beta-cell dysfunction. Diabetologia 46: 1228-1233 (2003)
14. Tuna M, Polat S, Erman T, Ildan F, Gocer AI, Tuna N, Tamer L, Kaya M, Cetinalp E. Effect of anti-rat interleukin-6 antibody after spinal cord injury in the rat: inducible nitric oxide synthase expression, sodium- and potassium-activated, magnesium-dependent adenosine-5′-triphosphatase and superoxide dismutase activation, and ultrastructural changes. J Neurosurg 95: 64-73 (2001)
15. Wadt KA, Larsen CM, Andersen HU, Nielsen K, Karlsen AE, Mandrup-Poulsen T. Ciliary neurotrophic factor potentiates the beta-cell inhibitory effect of IL-1 beta in rat pancreatic islets associated with increased nitric oxide synthesis and increased expression of inducible nitric oxide synthase. Diabetes 47: 1602-1608 (1998)