An enhanced expression of ABC 1 transporter in circulating leukocytes as a potential molecular marker for the diagnostics of glaucoma

Amino Acids

Volumn 28, Issue 2, 2005, Pages 207-211

  Yeghiazaryan, K ^a   Flammer, J ^b   Wunderlich, K ^b   Schild, H H ^a   Orgul, S ^b   Golubnitschaja, O ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

ABC transporter; Circulating leukocytes; Diagnostics; Glaucoma; Molecular monitoring ex vivo; Vascular dysregulation

Indexed keywords

ABC TRANSPORTER A1; BIOLOGICAL MARKER; CHOLESTEROL;

CELL LEVEL; CELLULAR DISTRIBUTION; COMPARATIVE ANATOMY; CONFERENCE PAPER; CONTROLLED STUDY; DISEASE MARKER; EX VIVO STUDY; FEMALE; GLAUCOMA; HUMAN; HUMAN CELL; LEUKOCYTE; MALE; MEMBRANE BIOLOGY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM;

AGED; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL MARKERS; GLAUCOMA; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; UP-REGULATION;

EID: 17044427217     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-005-0170-4     Document Type: Conference Paper

References (18)

1. Akiyama TE, Sakai S, Lambert G, Nicol CJ, Matsusue K, Pimprale S, Lee YH, Ricote M, Glass CK, Brewer HB Jr, Gonzalez FJ (2002) Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol Cell Biol 22: 2607-2619
2. Alward WL (2001) International Glaucoma Review. Editor's selection 3: 23
3. Bisoendial RJ, Hovingh GK, Levels JH, Lerch PG, Andresen I, Hayden MR, Kastelein JJ, Stroes ES (2003) Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein. Circulation 107: 2944-2948
4. Broccardo C, Luciani M, Chimini G (1999) The ABCA subclass of mammalian transporters. Biochim Biophys Acta 1461: 395-404
5. Brooks-Wilson A, Marcil M, Clee SM, Zhang L-H, Roomp K, van Dam M, Yu L, Brewer C, Collins JA, Molhuizen HOF, Loubser O, Ouelette BFF, Fichter K, Ashbourne-Excoffon KJD, Sensen CW, Scherer S, Mott S, Denis M, Martindale D, Frohlich J, Morgan K, Koop B, Pimstone S, Kastelein JJP, Hayden MR (1999) Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet 22: 336-345
6. Clee SM, Zwinderman AH, Engert JC, Zwarts KY, Molhuizen HOF, Roomp K, Jukema JW, van Wijland M, van Dam M, Hudson TJ, Brooks-Wilson A, Genest J Jr, Kastelein JJP, Hayden MR (2001) Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease. Circulation 103: 1198-1205
7. Efferth T (2003) Adenosine triphosphate-binding cassette transporter genes in ageing and age-related diseases. Ageing Res Rev 2: 11-24
8. Esser J, Esser P, Mietz H, Hueber A, Kociok N, Schraermeyer U, Krieglstein GK (2000) Multidrug resistance-associated proteins in glaucoma surgery. Graefes Arch Clin Exp Ophthalmol 238: 727-732
9. Golubnitschaja-Labudova O, Liu R, Decker C, Zhu P, Haefliger IO, Flammer J (2000) Altered gene expression in lymphocytes of patients with normal-tension glaucoma. Curr Eye Res 21: 867-876
10. Hayden MR (2001) Common genetic variation in ABCA1 is associated with altered lipoprotein levels and a modified risk for coronary artery disease. Circulation 103: 1198-1205
11. Joyce CW, Amar MJ, Lambert G, Vaisman BL, Paigen B, Najib-Fruchart J, Hoyt RF Jr, Neufeld ED, Remaley AT, Fredrickson DS, Brewer HB Jr, Santamarina-Fojo S (2002) The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice. Proc Natl Acad Sci USA 99: 407-412
12. Langmann T, Klucken J, Reil M, Liebisch G, Luciani MF, Chimini G, Kaminski WE, Schmitz G (1999) Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages. Biochem Biophys Res Commun 257: 29-33
13. Marcil M, Brooks-Wilson A, Clee SM, Roomp K, Zhang L-H, Yu L, Collins JA, van Dam M, Molhuizen HOF, Loubser O, Ouelette BFF, Sensen CW, Fichter K, Mott S, Denis M, Boucher B, Pimstone S, Genest J Jr, Kastelein JJP, Hayden MR (1999) Mutations in the ABC1 gene in familial HDL deficiency with defective cholesterol efflux. Lancet 354: 1341-1346
14. Orso E, Broccardo C, Kaminski WE, Bottcher A, Liebisch G, Drobnik W, Gotz A, Chambenoit O, Diederich W, Langmann T, Spruss T, Luciani MF, Rothe G, Lackner KJ, Chimini G, Schmitz G (2000) Transport of lipids from golgi to plasma membrane is defective in tangier disease patients and Abc1-deficient mice. Nat Genet 24: 192-196
15. Santamarina-Fojo S, Peterson K, Knapper C, Qiu Y, Freeman L, Cheng JF, Osorio J, Remaley A, Yang XP, Haudenschild C, Prades C, Chimini G, Blackmon E, Francois T, Duverger N, Rubin EM, Rosier M, Denefle P, Fredrickson DS, Brewer HB Jr (2000) Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter. Proc Natl Acad Sci USA 97: 7987-7992
16. Sun H, Smallwood PM, Nathans J (2000) Biochemical defects in ABCR protein variants associated with human retinopathies. Nat Genet 26: 242-246
17. Tomarev SI, Wistow G, Raymond V, Dubois S, Malyukova I (2003) Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. Invest Ophthalmol Vis Sci 44: 2588-2596
18. van Eck M, Bos IS, Kaminski WE, Orso E, Rothe G, Twisk I, Bottcher A, Van Amersfoort ES, Christiansen-Weber TA, Fung-Leung WP, Van Berkel TI, Schmitz G (2002) Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc Natl Acad Sci USA 99: 6298-6303