Acute toxicity of intravenously administered Microfabricated silicon dioxide drug delivery particles in mice: Priliminary findings

Drugs in R and D

Volumn 6, Issue 2, 2005, Pages 71-81

  Martin, F J ^a   Melnik, K ^a   West, T ^a   Shapiro, J ^a   Cohen, M ^a   Boiarski, A A ^a   Ferrari, M ^b  

^a iMEDD Inc   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG; DRUG CARRIER; NANOPARTICLE; SILICON DIOXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPSY; BIODEGRADABILITY; CLEARANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG SAFETY; EXPERIMENTAL MODEL; HISTOPATHOLOGY; LETHALITY; LUNG PARENCHYMA; MOUSE; NONHUMAN; OUTCOMES RESEARCH; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; SIMULATION; SURVIVAL; TISSUE DISTRIBUTION; TISSUE SECTION; WEIGHT REDUCTION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; INJECTIONS, INTRAVENOUS; MICE; MICROSPHERES; PARTICLE SIZE; SILICON DIOXIDE; TISSUE DISTRIBUTION;

EID: 17044426222     PISSN: 11745886     EISSN: None     Source Type: Journal    
DOI: 10.2165/00126839-200506020-00002     Document Type: Article

References (6)

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2. Lewis J, Ferrari M. BioMEMS for drug delivery applications. In: van den Berg A, editor. Lab-on-a chip: miniaturized systems for (bio)chemical analysis and synthesis. Boston: Elsevier, 2003
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4. Martin FJ, Grove C. Microfabricated drug delivery systems: concepts to improve clinical benefits. Biomed Microdevices 2001; 3 (2): 97-109
5. Cohen MH, Melnik K, Boiarski AA, et al. Microfabrication of silicon-based nanoporous particulates for medical applications. Biomed Microdevices 2003; 5 (3): 253-9
6. Conhaim RL, Rodenkirch LA. Functional diameters of alveolar microvessels at high lung volume in zone II. J Appl Physiol 1998; 85 (1): 47-52