Intrathecal methotrexate neurotoxicity: Clinical correlates and antidotal treatment

Environmental Toxicology and Pharmacology

Volumn 19, Issue 3, 2005, Pages 721-725

  Finkelstein, Yoram ^a   Zevin, Shoshana ^a   Raikhlin Eisenkraft, Bianca ^b   Bentur, Yedidia ^b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b RAMBAM MEDICAL CENTER   (Israel)

Author keywords

CSF exchange; Intrathecal dexamethasone; Intrathecal methotrexate; Leucovorin; Neurotoxicity; Overdose

Indexed keywords

CARBOXYPEPTIDASE G2; DEXAMETHASONE; FOLINIC ACID; METHOTREXATE;

BRAIN DISEASE; CEREBROSPINAL FLUID DRAINAGE; CLINICAL FEATURE; COMA; CONFERENCE PAPER; CONVULSION; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG FATALITY; DRUG OVERDOSE; HUMAN; LEUKOENCEPHALOPATHY; LOW BACK PAIN; MUSCLE HYPERTONIA; NEUROTOXICITY; NONHUMAN; PAIN; PRIORITY JOURNAL; SEIZURE; STUPOR; TREATMENT OUTCOME;

EID: 17044411331     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2004.12.031     Document Type: Conference Paper

References (37)

1. P.C. Adamson, F.M. Balis, C.L. McCully, K.S. Godwin, J.D. Bacher, T.J. Walsh, and D.G. Poplack Rescue of experimental intrathecal methotrexate overdose with carboxypeptidase-G2 J. Clin. Oncol. 9 1991 670
2. R.G. Blasberg, C.S. Patlak, and W.R. Shapiro Distribution of methotrexate in the cerebrospinal fluid and brain after intraventricular administration Cancer Treat. Rep. 61 1977 633
3. W.A. Bleyer The clinical pharmacology of methotrexate: new applications of an old drug Cancer 41 1978 36
4. W.A. Bleyer Neurologic sequelae of methotrexate and ioninzing radiation: a new classification Cancer Treat. Rep. 65 1981 89
5. R.W. Erbe Inborn errors of folate metabolism N. Engl. J. Med. 293 1975 753
6. L.J. Ettinger Pharmacokinetics and biochemical effects of a fatal intrathecal methotrexate overdose Cancer 50 1982 44
7. Y. Finkelstein, S. Zevin, J. Heyd, Y. Bentur, Y. Zigelman, and M. Hersch Emergency treatment of life-threatening intrathecal methotrexate overdose Neurotoxicology 25 2004 407
8. E. Frei 3rd., N. Jaffe, M.H. Tattersall, S. Pitman, and L. Parker New approaches to cancer chemotherapy with methotrexate N. Engl. J. Med. 292 1975 846
9. G.I. Hankey, and J.W. Eikelboom Homocysteine and stroke Curr. Opin. Neurol. 14 2001 95
10. A.H. Harila-Saari, L.K. Vainionpaa, T.T. Kovala, E.U. Tolonen, and B.M. Lanning Nerve lesions after therapy for childhood acute lymphoblastic leukaemia Cancer 82 1998 200
11. N. Jaffe, E. Frei 3rd., D. Traggis, and Y. Bishop Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma N. Engl. J. Med. 291 1974 994
12. N. Jaffe, Y. Takaue, T. Anzai, and R. Robertson Transient neurologic disturbances induced by high-dose methotrexate treatment Cancer 56 1985 1356
13. A.M. Jakobson, A. Kreuger, O. Mortimer, S. Henningsson, H. Seidel, and P.J. Moe Cerebrospinal fluid exchange after intrathecal methotrexate overdose. A report of two cases Acta Paediatr. 81 1992 359
14. L.F. Jardine, L.C. Ingram, and W.A. Bleyer Intrathecal leucovorin after intrathecal methotrexate overdose J. Pediatr. Hematol. Oncol. 18 1996 302
15. F. Keime-Guibert, M. Napolitano, and J.Y. Delattre Neurological complications of radiotherapy and chemotherapy (review) Neuro-oncol 245 1998 695
16. R. Lai, L.E. Abrey, M.K. Rosenblum, and L.M. DeAngelis Treatment-induced leukoencephalopathy in primary CNS lymphoma Neurology 62 2004 451
17. A.C. Lee, K.W. Wong, K.W. Fong, and K.T. So Intrathecal methotrexate overdose Acta Paediatr. 86 1997 434
18. H.H. Lien, V. Blomlie, G. Saeter, O. Solheim, and S.D. Fossa Osteogenic sarcoma: MR signal abnormalities of the brain in asymptomatic patients treated with high-dose methotrexate Radiology 179 1991 547
19. K. Lovblad, P. Kelkar, C. Ozdoba, G. Ramelli, L. Remonda, and G. Schroth Pure methotrexate encephalopathy presenting with seizures: CT and MRI findings Pediatr. Radiol. 28 1998 86
20. R.L. Martino, A.B. Benson III., and J.A. Merritt Transient neurologic dysfunction following moderate-dose methotrexate for undifferentiated lymphoma Cancer 1984 54
21. N.J. Meropol, P.J. Creaven, N.J. Petrelli, R.M. White, and S.G. Arbuck Seizures associated with leucovorin administration in cancer patients J. Natl. Cancer Inst. 87 1995 56
22. A.S. O'Marcaigh, C.M. Johnson, W.A. Smithson, M.C. Patterson, B.C. Widemann, P.C. Adamson, and M.J. McManus Successful treatment of intrathecal methotrexate overdose by using ventriculolumbar perfusion and intrathecal instillation of carboxypeptidase G2 Mayo Clin. Proc. 71 1996 161
23. R.J. Packer, R.A. Zimmerman, J. Rosenstock, L.B. Rorke, D.G. Norris, and P.H. Berman Focal encephalopathy following methotrexate therapy administration via a misplaced intraventricular catheter Arch. Neurol. 38 1981 450
24. H. Peyriere, M. Poiree, M. Cociglio, G. Margueritte, S. Hansel, and D. Hillaire-Buys Reversal of neurologic disturbances related to high-dose methotrexate by aminophylline Med. Pediatr. Oncol. 36 2001 662
25. R.A. Prince, and P.A. Jamieson The central nervous system in childhood leukemia. II. Subacute leukoencophalopathy Cancer 35 1975 306
26. C.T. Quinn, and B.A. Kamen A biochemical perspective of methotrexate neurotoxicity with insight on nonfolate modalities J. Invest. Med. 44 1996 552
27. R.E. Rieselbach, G. Di Chiro, E.J. Freireich, and D.P. Rall Subarachnoid distribution of drugs after lumbar injection N. Engl. J. Med. 267 1962 1273
28. L. Riva, V. Conter, C. Rizzari, M. Jankovic, A. Sala, and M. Milani Successful treatment of intrathecal methotrexate overdose with folinic acid rescue: a case report Acta. Paediatr. 88 1999 780
29. L.J. Rubinstein, M.M. Herman, and T.G. Long Disseminated necrotizing leukoencephalopathy: a complication of treated central nervous system leukemia and lymhoma Cancer 35 1975 291
30. W.R. Shapiro, D.F. Young, and B.M. Mehta Methotrexate: distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections N. Engl. J. Med. 293 1975 161
31. T. Shore, M.J. Barnett, and G.L. Phillips Sudden neurologic death after intrathecal methotrexate Med. Ped. Oncol. 18 1990 159
32. A. Shuper, B. Stark, and L. Kornreich Methotrexate treatment protocols and the central nervous system: significant cure with significant neurotoxicity J. Child Neurol. 15 2000 573
33. D.B. Smith, and G.F. Carl Interactions between folates and carbamazepine or valproate in the rat Neurology 32 1982 965
34. R.J. Spiegel, P.R. Cooper, R.H. Blum, J.L. Speyer, D. McBride, and J. Mangiardi Treatment of massive intrathecal methotrexate overdose by ventriculolumbar perfusion N. Engl. J. Med. 311 1984 386
35. S. Vezmar, A. Becker, U. Bode, and U. Jaehde Biochemical and clinical aspects of methotrexate neurotoxicity Chemotherapy 49 2003 92
36. R.W. Walker, J.C. Allen, and G. Rosen Transient cerebral dysfunction secondary to high-dose methotrexate J. Clin. Oncol. 4 1986 1845
37. J. Watterson, I. Toogood, M. Nieder, M. Morse, S. Frierdich, and Y. Lee Excessive spinal cord toxicity from intensive central nervous system-directed therapies Cancer 74 1994 3034