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Volumn 6, Issue 2, 2005, Pages 120-127

Mecasermin rinfabate: Insulin-like growth factor-I/insulin-like growth factor binding protein-3, mecaserimin rinfibate, rhIGF-I/rhIGFBP-3
[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; INSULIN; MECASERMIN RINFABATE; ORPHAN DRUG; PLACEBO; PROTEINASE; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

EID: 17044409041     PISSN: 11745886     EISSN: None     Source Type: Journal    
DOI: 10.2165/00126839-200506020-00008     Document Type: Article
Times cited : (8)

References (25)
  • 1
    • 17044420632 scopus 로고    scopus 로고
    • Insured Acquires Manufacturing Facility from Baxter International
    • Insmed Incorporated. Media Release: 14 Apr Available from URL:
    • Insmed Incorporated. Insured Acquires Manufacturing Facility from Baxter International. Media Release: 14 Apr 2004. Available from URL: http://www.insmed.com
    • (2004)
  • 2
    • 17044422361 scopus 로고    scopus 로고
    • Insmed and Tzamal Pharma Announce Agreement for the Promotion and Distribution of SomatoKine in Middle Eastern Territories; Tzamal to Immediately Expand SomatoKine Named Patient Program
    • Insmed Incorporated. Media Release: 21 Oct Available from URL:
    • Insmed Incorporated. Insmed and Tzamal Pharma Announce Agreement for the Promotion and Distribution of SomatoKine in Middle Eastern Territories; Tzamal to Immediately Expand SomatoKine Named Patient Program. Media Release: 21 Oct 2004. Available from URL: http://www.insmed.com
    • (2004)
  • 3
    • 17044381490 scopus 로고    scopus 로고
    • Insmed Reports Update on Pivotal Clinical Trial with SomatoKine: Statistically Significant Increase in Growth Rate Observed at Six Months
    • Insmed Incorporated. Media Release: 20 Jul Available from URL:
    • Insmed Incorporated. Insmed Reports Update on Pivotal Clinical Trial with SomatoKine: Statistically Significant Increase in Growth Rate Observed at Six Months. Media Release: 20 Jul 2004. Available from URL: http://www.insmed.com
    • (2004)
  • 4
    • 17044436264 scopus 로고    scopus 로고
    • Insmed Acquires IGF-1 Regulatory Files for Growth Hormone Insensitivity Syndrome From Pharmacia; Extensive Regulatory Files Expected to Expedite Commercialization of SomatoKine
    • Insmed Incorporated. Media Release: 7 Oct Available from URL:
    • Insmed Incorporated. Insmed Acquires IGF-1 Regulatory Files for Growth Hormone Insensitivity Syndrome From Pharmacia; Extensive Regulatory Files Expected to Expedite Commercialization of SomatoKine. Media Release: 7 Oct 2002. Available from URL: http://www.insmed.com
    • (2002)
  • 5
    • 0142100903 scopus 로고    scopus 로고
    • Insmed Reports Positive Effects of SomatoKine -rhIGF-I/rhIGFBP-3- In Adolescent Subjects With Type 1 Diabetes
    • Insmed Incorporated. Media Release: 29 Jan Available from URL:
    • Insmed Incorporated. Insmed Reports Positive Effects of SomatoKine -rhIGF-I/rhIGFBP-3- In Adolescent Subjects With Type 1 Diabetes. Media Release: 29 Jan 2003. Available from URL: http://www.insmed.com
    • (2003)
  • 6
    • 17044418952 scopus 로고    scopus 로고
    • rhIGF-I/rhIGFBP-3, SomatoKine, Found to Delay the Onset of Type 1 Diabetes
    • Insmed Incorporated. Media Release: 2 Dec Available from URL:
    • Insmed Incorporated. rhIGF-I/rhIGFBP-3, SomatoKine, Found to Delay the Onset of Type 1 Diabetes. Media Release: 2 Dec 2003. Available from URL: http://www.insmed.com
    • (2003)
  • 7
    • 17044396529 scopus 로고    scopus 로고
    • Insmed Receives FDA Orphan Drug Designation For rhIGF-I/rhIGFBP-3, SomatoKine, for Extreme Insulin Resistance
    • Insmed Incorporated. Media Release: 15 Dec Available from URL:
    • Insmed Incorporated. Insmed Receives FDA Orphan Drug Designation For rhIGF-I/rhIGFBP-3, SomatoKine, for Extreme Insulin Resistance. Media Release: 15 Dec 2003. Available from URL: http://www.insmed.com
    • (2003)
  • 8
    • 17044363327 scopus 로고    scopus 로고
    • Insmed Receives European Orphan Drug Designation for SomatoKine for the Treatment of Extreme Insulin Resistance; Company to Initiate Clinial Trial in Type A Insulin Resistance
    • Insmed Incorporated. Media Release: 25 Oct Available from URL:
    • Insmed Incorporated. Insmed Receives European Orphan Drug Designation for SomatoKine for the Treatment of Extreme Insulin Resistance; Company to Initiate Clinial Trial in Type A Insulin Resistance. Media Release: 25 Oct 2004. Available from URL: http://www.insmed.com
    • (2004)
  • 9
    • 17044377294 scopus 로고    scopus 로고
    • Insmed Announces Expansion of Patent Portfolio in the Treatment of Diabetes; New European Patent Granted for SomatoKine
    • Insmed Incorporated. Media Release: 9 Nov Available from URL:
    • Insmed Incorporated. Insmed Announces Expansion of Patent Portfolio in the Treatment of Diabetes; New European Patent Granted for SomatoKine. Media Release: 9 Nov 2004. Available from URL: http://www.insmed.com
    • (2004)
  • 10
    • 17044427348 scopus 로고    scopus 로고
    • Insmed Obtains Patent Rights for Extreme Insulin Resistance From Fujisawa
    • Insmed Incorporated. Media Release: 26 Jan Available from URL:
    • Insmed Incorporated. Insmed Obtains Patent Rights for Extreme Insulin Resistance From Fujisawa. Media Release: 26 Jan 2004. Available from URL: http://www.insmed.com
    • (2004)
  • 11
    • 17044425789 scopus 로고    scopus 로고
    • Insmed Provides Response to UK Patent Lawsuit
    • Insmed Incorporated. Media Release: 16 Feb Available from URL:
    • Insmed Incorporated. Insmed Provides Response to UK Patent Lawsuit. Media Release: 16 Feb 2005. Available from URL: http://www.insmed.com
    • (2005)
  • 12
    • 0142100908 scopus 로고    scopus 로고
    • Celtrix completes phase I studies of SomatoKine, demonstrating not only safety at high doses but also stimulation of bone and connective tissue metabolism
    • 18 Jan
    • Celtrix completes phase I studies of SomatoKine, demonstrating not only safety at high doses but also stimulation of bone and connective tissue metabolism. Inpharma 1070: 10, 18 Jan 1997
    • (1997) Inpharma , vol.1070 , pp. 10
  • 13
    • 0142069278 scopus 로고    scopus 로고
    • Insmed Presents Positive Data on Lead Drug Candidate at Endocrine Society Annual Meeting; Study Shows Advantages of Company's rhIGF-I/rhIGFBP-3 In Treating Growth Disorder
    • Insmed Incorporated. Media Release: 20 Jun Available from URL:
    • Insmed Incorporated. Insmed Presents Positive Data on Lead Drug Candidate at Endocrine Society Annual Meeting; Study Shows Advantages of Company's rhIGF-I/rhIGFBP-3 In Treating Growth Disorder. Media Release: 20 Jun 2003. Available from URL: http://www.insmed.com
    • (2003)
  • 14
    • 17044370591 scopus 로고    scopus 로고
    • Pharmacokinetic studies of rhIGF-I/rhIGFBP-3 complex administered to patients with growth hormone insensitivity syndrome
    • 85th Annual Meeting of the Endocrine Society 19 Jun Available from:URL:
    • Camacho-Hübner C, Storr HL, Miraki-Moud F, et al. Pharmacokinetic studies of rhIGF-I/rhIGFBP-3 complex administered to patients with growth hormone insensitivity syndrome. 85th Annual Meeting of the Endocrine Society: 19 Jun 2003. Available from:URL: http://www.endo-society.org
    • (2003)
    • Camacho-Hübner, C.1    Storr, H.L.2    Miraki-Moud, F.3
  • 15
    • 17044438846 scopus 로고    scopus 로고
    • Population pharmacokinetics of insulin-like growth factor-I in type I and II diabetic patients and in healthy adults
    • Jun
    • Liao S, Hsieh F, Bright GM. Population pharmacokinetics of insulin-like growth factor-I in type I and II diabetic patients and in healthy adults. Diabetes 53 (Suppl. 2): 134-135, Jun 2004
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 2 , pp. 134-135
    • Liao, S.1    Hsieh, F.2    Bright, G.M.3
  • 16
    • 18444393384 scopus 로고    scopus 로고
    • Musculoskeletal effects of the recombinant human IGF-I/IGF binding protein-3 complex in osteoporotic patients with proximal femoral fracture: A double-blind, placebo-controlled pilot study
    • Apr
    • Boonen S, Rosen C, Bouillon R, et al. Musculoskeletal effects of the recombinant human IGF-I/IGF binding protein-3 complex in osteoporotic patients with proximal femoral fracture: a double-blind, placebo-controlled pilot study. Journal of Clinical Endocrinology and Metabolism 87: 1593-1599, Apr 2002
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , pp. 1593-1599
    • Boonen, S.1    Rosen, C.2    Bouillon, R.3
  • 17
    • 17044408166 scopus 로고    scopus 로고
    • Celtrix's SomatoKine Demonstrates Positive Effects in Diabetes Patients; Insulin Usage Lowered by 49%
    • Celtrix Pharmaceuticals Inc. Media Release [2 pages]: 25 Feb
    • Celtrix Pharmaceuticals Inc. Celtrix's SomatoKine demonstrates positive effects in diabetes patients; insulin usage lowered by 49%. Media Release [2 pages]: 25 Feb 1999
    • (1999)
  • 18
    • 0142037336 scopus 로고    scopus 로고
    • Combined recombinant human insulin-like growth factor 1/insulin-like growth factor binding protein 3 suppresses growth hormone secretion and improves insulin sensitivity in adolescents with type 1 diabetes
    • Jun
    • Saukkonen T, Amin R, Williams R, et al. Combined recombinant human insulin-like growth factor 1/insulin-like growth factor binding protein 3 suppresses growth hormone secretion and improves insulin sensitivity in adolescents with type 1 diabetes. Diabetes 52 (Suppl. 1): 132-133, Jun 2003
    • (2003) Diabetes , vol.52 , Issue.SUPPL. 1 , pp. 132-133
    • Saukkonen, T.1    Amin, R.2    Williams, R.3
  • 19
    • 4544238815 scopus 로고    scopus 로고
    • Dose-dependent effects of recombinant human insulin-like growth factor (IGF)-I/IGF binding protein-3 complex on overnight growth hormone secretion and insulin sensitivity in type 1 diabetes
    • No. 9, Sep
    • Saukkonen T, Amin R, Williams RM, et al. Dose-dependent effects of recombinant human insulin-like growth factor (IGF)-I/IGF binding protein-3 complex on overnight growth hormone secretion and insulin sensitivity in type 1 diabetes. Journal of Clinical Endocrinology and Metabolism 89: 4634-4641, No. 9, Sep 2004
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , pp. 4634-4641
    • Saukkonen, T.1    Amin, R.2    Williams, R.M.3
  • 20
    • 0142100909 scopus 로고    scopus 로고
    • Insmed Reports Positive Effects of SomatoKine in Subjects with type 2 Diabetes
    • Insmed Incorporated. Media Release [2 pages]: 8 Jan Available from URL:
    • Insmed Incorporated. Insmed reports positive effects of SomatoKine in subjects with type 2 diabetes. Media Release [2 pages]: 8 Jan 2002. Available from URL: http://www.insmed.com
    • (2002)
  • 21
    • 0142037325 scopus 로고    scopus 로고
    • A double-blind, randomized, placebo-controlled study to determine the dose response profile of rhIGF-I/rhIGFBP-3 in subjects with type 2 diabetes mellitus requiring insulin therapy
    • (plus poster), Jun
    • Rogol AD, Sommer A, Jacobson W, et al. A double-blind, randomized, placebo-controlled study to determine the dose response profile of rhIGF-I/rhIGFBP-3 in subjects with type 2 diabetes mellitus requiring insulin therapy. Diabetes 51 (Suppl. 2): 143 (plus poster), Jun 2002
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2 , pp. 143
    • Rogol, A.D.1    Sommer, A.2    Jacobson, W.3
  • 22
    • 85009046159 scopus 로고    scopus 로고
    • Combination recombinant human insulin-like growth factor 1 and IGF binding protein 3 reduces insulin requirements and improves glycemic control in type 1 diabetes
    • May
    • Moses AC, Sommer A, Malcolm M, et al. Combination recombinant human insulin-like growth factor 1 and IGF binding protein 3 reduces insulin requirements and improves glycemic control in type 1 diabetes. Diabetes 48 (Suppl. 1): 93, May 1999
    • (1999) Diabetes , vol.48 , Issue.SUPPL. 1 , pp. 93
    • Moses, A.C.1    Sommer, A.2    Malcolm, M.3
  • 23
    • 0142132568 scopus 로고    scopus 로고
    • Initial Clinical Results Reported on Celtrix's SomatoKine Treatment for Severe Burns
    • BW HealthWire [online, 3 pages]: 5 May Available from URL:
    • Initial clinical results reported on Celtrix's SomatoKine treatment for severe burns. BW HealthWire [online, 3 pages]: 5 May 1998. Available from URL: http://www.newspage.com
    • (1998)
  • 24
    • 17044398348 scopus 로고    scopus 로고
    • Celtrix's SomatoKline improves cardiac function in victims of burn trauma; results have potential widespread application for heart patients
    • [online, 2 pages]: 20 Nov Available from URL:
    • Celtrix's SomatoKline improves cardiac function in victims of burn trauma; results have potential widespread application for heart patients. BW HealthWire [online, 2 pages]: 20 Nov 1998. Available from URL: http://www.newspage.com
    • (1998) BW HealthWire
  • 25
    • 0142100901 scopus 로고    scopus 로고
    • Celtrix's SomatoKine Ddemonstrates Significant Effects in the Treatment of Trauma-induced Protein Wasting; Results of Phase II Severe Burns Trial
    • Celtrix Pharmaceuticals Inc. Media Release [2 pages]: 10 Dec
    • Celtrix Pharmaceuticals Inc. Celtrix's SomatoKine demonstrates significant effects in the treatment of trauma-induced protein wasting; results of phase II severe burns trial. Media Release [2 pages]: 10 Dec 1998
    • (1998)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.