High mitochondrial redox potential may promote induction and activation of UCP2 in hepatocytes during hepatothermic therapy

Medical Hypotheses

Volumn 64, Issue 6, 2005, Pages 1216-1219

  McCarty, Mark F ^a  

^a NutriGuard Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIC ACID DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PRASTERONE; SUPEROXIDE; THYROMIMETIC AGENT; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

BODY FAT; FATTY ACID OXIDATION; HOMEOSTASIS; LIVER CELL; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; REVIEW; STEATOSIS; THERMOGENESIS;

EID: 17044392211     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2004.01.040     Document Type: Article

References (23)

1. McCarty M.F., Gustin J.C. Pyruvate and hydroxycitrate/carnitine may synergize to promote reverse electron transport in hepatocyte mitochondria, effectively 'uncoupling' the oxidation of fatty acids. Med. Hypotheses. 52:1999;407-416
2. McCarty M.F. Hepatothermic therapy of obesity: rationale and an inventory of resources. Med. Hypotheses. 57:2001;324-336
3. Negre-Salvayre A., Hirtz C., Carrera G., Cazenave R., Troly M., Salvayre R., et al. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. FASEB J. 11:1997;809-815
4. Larrouy D., Laharrague P., Carrera G., Viguerie-Bascands N., Levi-Meyrueis C., Fleury C., et al. Kupffer cells are a dominant site of uncoupling protein 2 expression in rat liver. Biochem. Biophys. Res. Commun. 235:1997;760-764
5. Kimura K., Jung B.D., Kanehira K., Irie Y., Canas X., Saito M. Induction of uncoupling protein (UCP) 2 in primary cultured hepatocytes. FEBS Lett. 457:1999;75-79
6. Chavin K.D., Yang S., Lin H.Z., Chatham J., Chacko V.P., Hoek J.B., et al. Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion. J. Biol. Chem. 274:1999;5692-5700
7. Yang S., Zhu H., Li Y., Lin H., Gabrielson K., Trush M.A., et al. Mitochondrial adaptations to obesity-related oxidant stress. Arch. Biochem. Biophys. 378:2000;259-268
8. Lee F.Y., Li Y., Zhu H., Yang S., Lin H.Z., Trush M., et al. Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [correction of rat] liver. Hepatology. 29:1999;677-687
9. Faggioni R., Shigenaga J., Moser A., Feingold K.R., Grunfeld C. Induction of UCP2 gene expression by LPS: a potential mechanism for increased thermogenesis during infection. Biochem. Biophys. Res. Commun. 244:1998;75-78
10. Cortez-Pinto H., Zhi L.H., Qi Y.S., Odwin D.C., Diehl A.M. Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes. Gastroenterology. 116:1999;1184-1193
11. Nakatani T., Tsuboyama-Kasaoka N., Takahashi M., Miura S., Ezaki O. Mechanism for peroxisome proliferator-activated receptor-alpha activator-induced up-regulation of UCP2 mRNA in rodent hepatocytes. J. Biol. Chem. 277:2002;9562-9569
12. Li L.X., Skorpen F., Egeberg K., Jorgensen I.H., Grill V. Induction of uncoupling protein 2 mRNA in beta-cells is stimulated by oxidation of fatty acids but not by nutrient oversupply. Endocrinology. 143:2002;1371-1377
13. Echtay K.S., Roussel D., St Pierre J., Jekabsons M.B., Cadenas S., Stuart J.A., et al. Superoxide activates mitochondrial uncoupling proteins. Nature. 415:2002;96-99
14. Echtay K.S., Murphy M.P., Smith R.A., Talbot D.A., Brand M.D. Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J. Biol. Chem. 277:2002;47129-47135
15. Arsenijevic D., Onuma H., Pecqueur C., Raimbault S., Manning B.S., Miroux B., et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat. Genet. 26:2000;435-439
16. Cadenas S., Echtay K.S., Harper J.A., Jekabsons M.B., Buckingham J.A., Grau E., et al. The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. J. Biol. Chem. 277:2002;2773-2778
17. Cadenas S., Echtay K.S., Harper J.A., Jekabsons M.B., Buckingham J.A., Grau E., et al. The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. J. Biol. Chem. 277:2002;2773-2778
18. Cadenas S., Buckingham J.A., Samec S., Seydoux J., Din N., Dulloo A.G., et al. UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged. FEBS Lett. 462:1999;257-260
19. Skulachev V.P. Uncoupling: new approaches to an old problem of bioenergetics. Biochim. Biophys. Acta. 1363:1998;100-124
20. Lardy H., Partridge B., Kneer N., Wei Y. Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone. Proc. Natl. Acad. Sci. USA. 92:1995;6617-6619
21. Bobyleva V., Bellei M., Kneer N., Lardy H. The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis. Arch. Biochem. Biophys. 341:1997;122-128
22. Armstrong M.B., Towle H.C. Polyunsaturated fatty acids stimulate hepatic UCP-2 expression via a PPARalpha-mediated pathway. Am. J. Physiol. Endocrinol. Metab. 281:2001;E1197-E1204
23. Grav H.J., Tronstad K.J., Gudbrandsen O.A., Berge K., Fladmark K.E., Martinsen T.C., et al. Changed energy state and increased mitochondrial beta-oxidation rate in liver of rats associated with lowered proton electrochemical potential and stimulated uncoupling protein 2 (UCP-2) expression: evidence for peroxisome proliferator-activated receptor-alpha independent induction of UCP-2 expression. J. Biol. Chem. 278:2003;30,525-30,533