Neutralization of a clade B primary isolate by sera from human immunodeficiency virus-uninfected recipients of candidate AIDS vaccines

Journal of Infectious Diseases

Volumn 175, Issue 4, 1997, Pages 764-774

  Zolla Pazner, Susan ^a   Alving, Carl ^c   Belshe, Robert ^c   Berman, Phillip ^c   Burda, Sherri ^c   Chigurupati, Padmasree ^b   Clements, Mary Lou ^c   Duliege, Anne Marie ^c   Excler, Jean Louis ^c   Hioe, Catarina ^c   Kahn, James ^c   McElrath, M Juliana ^c   Sharpe, Sandra ^c   Sinangil, Faruk ^c   Steimer, Kathelyn ^c   Walker, Mary Clare ^c   Wassef, Nabila ^c   Xu, Serena ^c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Paracelsian Inc   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG RESPONSE; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; VIRUS NEUTRALIZATION;

EID: 16944367422     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/513969     Document Type: Article

References (15)

1. Robbins JB, Schneerson R, Szu SC. Hypothesis: scrum IgG antibody is sufficient to confer protection against infectious diseases by inactivating the inoculum. J Infect Dis 1995; 171:1387-98.
2. Emini EA, Nara PL, Schlief WA, et al. Antibody-mediated in vitro neutralization of human immunodeficiency virus type 1 abolishes infectivity for chimpanzees. J Virol 1990;64:3674-8.
3. Emini EA, Schleif WA, Nunberg JH, et al. Prevention of HIV-1 infection in chimpanzees by gp120 V3 domain-specific monoclonal antibody. Nature 1992;355:728-30.
4. Prince AM, Horowitz B, Shulman RW, et al. Apparent prevention of HIV infection by HIV immunoglobulin given prior to low-dose HIV challenge. In: Brown F, ed. Vaccines '90: Modem approaches to new vaccines including prevention of AIDS. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1990:347-51.
5. Prince AM, Horowitz B, Baker L, et al. Failure of a human immunodeficiency virus (HIV) immune globulin to protect chimpanzees against experimental challenge with HIV. Proc Natl Acad Sci USA 1988;85: 6944-8.
6. Gauduin MC, Safrit JT, Weir R, Fung MSC, Koup RA. Pre- and postexposure protection against human immunodeficiency virus type 1 infection mediated by a monoclonal antibody. J Infect Dis 1995;171:1203-9.
7. Safrit JT, Fung MSC, Andrews CA, et al. Hu-PBL-SCID mice can be protected from HIV-1 infection by passive transfer of monoclonal antibody to the principal neutralizing determinant of envelope gp120. AIDS 1993;7:15-21.
8. Andrus L, Prince AM, Bernal I, et al. Passive immunization with a human HIV-1 neutralizing monoclonal antibody in hu-PBL-SCID mice: characterization of a neutralization escape variant. Seventh National Cooperative Vaccine Development Groups Conference. Bethesda, MD: National Institutes of Health, Division of AIDS, 1994;43.
9. Honda M, Matsuo K, Nakasone T, et al. Protective immune responses induced by secretion of a chimeric soluble protein from a recombinant Mycobacterium bovis bacillus Calmette-Guérin vector candidate vaccine for human immunodeficiency virus type 1 in small animals. Proc Natl Acad Sci USA 1995;92:10693-7.
10. Girard M, Meignier B, Barre-Sinoussi F, et al. Vaccine-induced protection of chimpanzees against infection by a heterologous human immunodeficiency virus type 1. J Virol 1995;69:6239-48.
11. Girard M, Kieny MP, Pinter A, et al. Immunization of chimpanzees confers protection against challenge with human immunodeficiency virus. Proc Natl Acad Sci USA 1991;88:542-6.
12. Berman PW, Gregory TJ, Riddle L, et al. Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant glycoprotein gp120 but not gp160. Nature 1990;345:622-5.
13. El Amad Z, Murthy KK, Heggins K, et al. Resistance of chimpanzees immunized with recombinant gp120(SF2). AIDS 1995;9:1313-22.
14. Bruck C, Thiriart C, Fabry L, et al. HIV-1 envelope elicited neutralizing antibody titres correlate with protection and virus load in chimpanzees [abstract]. J Cell Biochem Suppl 1993;17E:88.
15. Bruck C, Thiriart C, Delers A, et al. Comparison of vaccine protection in chimpanzees immunized with two different forms of recombinant HIV-1 envelope glycoprotein [abstract]. AIDS Res Hum Retroviruses 1993; 9:S110.