Long-term protection of chimpanzees against high-dose HIV-1 challenge induced by immunization

Nature Medicine

Volumn 3, Issue 6, 1997, Pages 651-658

  Lubeck, Michael D ^a,g   Natuk, Robert ^a,h   Myagkikh, Maria ^b   Kalyan, Narender ^a,h   Aldrich, Kristine ^b   Sinangil, Faruk ^c   Alipanah, Shabnam ^b   Murthy, Shri C S ^a   Chanda, Pranab K ^a   Nigida Jr , Stephen M ^d   Markham, Phillip D ^e   Zolla Pazner, Susan ^f   Steimer, Kathy ^c   Wade, Mark ^a   Reitz Jr , Marvin S ^b,k   Arthur, Larry O ^d   Mizutani, Satoshi ^a,h   Davis, Alan ^a,i   Hung, Paul P ^a,j   Gallo, Robert C ^b,k   Eichberg, Jorg ^a,l   Robert Guroff, Marjorie ^b   more..

^a WYETH AYERST RESEARCH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d NATIONAL CANCER INSTITUTE   (United States)

^e ADVANCED BIOSCIENCE LABORATORIES INC   (United States)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

^g Wyeth Lederle Vaccines and Pediat   (United States)

^h PFIZER INC   (United States)

ⁱ UNIVERSITY OF PENNSYLVANIA   (United States)

^j University of Maryland at Baltimore ^*  (United States)

^k UNIVERSITY OF MARYLAND   (United States)

^l BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 120; GLYCOPROTEIN GP 160; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CELLULAR IMMUNITY; CHIMPANZEE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; IMMUNIZATION; NONHUMAN; PRIORITY JOURNAL; SEROCONVERSION; VIRUS REPLICATION; VIRUS SHEDDING;

ADENOVIRIDAE; ANIMALS; FEMALE; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP160; HIV INFECTIONS; HIV-1; PAN TROGLODYTES; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; VACCINATION; VACCINES;

EID: 16944366094     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0697-651     Document Type: Article

References (14)

1. Hu, S.L. et al. Effect of immunization with a vaccinia-HIV env recombinant on HIV infection of chimpanzees. Nature 328, 721-723 (1987).
2. Berman, P.W. et al. Human immunodeficiency virus type 1 challenge of chimpanzees immunized with recombinant envelope glycoprotein gp120. Proc. Natl. Acad. Sci. USA 85, 5200-5204 (1988).
3. Arthur, L.O. et al. Challenge of chimpanzees (Pan troglodytes) immunized with human immunodeficiency virus envelope glycoprotein gp120. J. Virol. 63, 5046-5053 (1989).
4. Berman, P.W. et al. Protection of chimpanzees from infection by HIV-1 after vaccination with recombinant gp120 but not gp160 glycoproteins. Nature 345, 622-625 (1990).
5. Girard, M. et al. Immunization of chimpanzees confers protection against challenge with human immunodeficiency virus. Proc. Natl. Acad. Sci. USA 88, 542-546 (1991).
6. Fultz, P.N. et al. Vaccine protection of chimpanzees against challenge with HIV-1-infected peripheral blood mononuclear cells. Science 256, 1687-1690 (1992).
7. Niedrig, M. et al. Immune response of chimpanzees after immunization with the inactivated whole immunodeficiency virus (HIV-1), three different adjuvants and challenge. Vaccine 11, 67-74 (1993).
8. Bruck, C. et al. HIV-1 envelope-elicited neutralizing antibody titres correlate with protection and virus load in chimpanzees. Vaccine 12, 1141-1148 (1994).
9. Girard, M. et al. Vaccine-induced protection of chimpanzees against infection by a heterologous human immunodeficiency virus type 1. J. Virol. 69, 6239-6248 (1995).
10. Natuk, R.J. et al. Immunogenicity of recombinant human adenovirus-human immunodeficiency virus vaccines in chimpanzees. AIDS Res. Hum. Retroviruses 9, 395-404 (1993).
11. Lubeck, M.D. et al. Immunogenicity of recombinant adenovirus-human immunodeficiency virus vaccines in chimpanzees following intranasal administration [erratum appears in AIDS Res. Hum. Retroviruses 11, 189; 1995]. AIDS Res. Hum. Retroviruses 10, 1443-1449 (1994).
12. Berman, P.W. et al. Protection of MN-rgp120-immunized chimpanzees from heterologous infection with a primary isolate of human immunodeficiency virus type 1. J Infect. Dis. 173, 52-59 (1996).
13. Girard, M. et al. Failure of a human immunodeficiency virus type 1 (HIV-1) subtype B-derived vaccine to prevent infection of chimpanzees by an HIV-1 subtype E strain. J. Virol. 70, 8229-8233 (1996).
14. Shenk, T. Adenoviridae: The viruses and their replication, in: Fields Virology, (eds. Fields, B.N., Knipe, D.M. & Howley, P.M.) 2111-2148 (Lippincott-Raven, Philadelphia, 1996).