DNA image cytometric measurement as a surrogate end point biomarker in a phase I trial of α-difluoromethylornithine for cervical intraepithelial neoplasia

Cancer Epidemiology Biomarkers and Prevention

Volumn 6, Issue 10, 1997, Pages 849-855

  Boiko, Iouri V ^a   Mitchell, Michele Follen ^a,c   Pandey, Dilip K ^a   Allen White, R ^a   Hu, Wei ^a   Malpica, Anais ^a,d   Nishioka, Kenji ^a,e   Boone, Charles W ^b   Neely Atkinson, E ^a   Hittelman, Walter N ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d Brown and Assoc Med Laboratories   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EFLORNITHINE;

ADULT; ARTICLE; CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CLINICAL ARTICLE; CLINICAL TRIAL; DNA DETERMINATION; DRUG RESPONSE; FEMALE; HUMAN; HUMAN TISSUE; IMAGE CYTOMETRY; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; TREATMENT OUTCOME; TUMOR BIOPSY; UTERINE CERVIX BIOPSY; UTERINE CERVIX CARCINOMA IN SITU;

ADULT; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS; CERVICAL INTRAEPITHELIAL NEOPLASIA; CLINICAL TRIALS, PHASE I; DNA, NEOPLASM; EFLORNITHINE; FEMALE; HUMANS; IMAGE CYTOMETRY; IMAGE PROCESSING, COMPUTER-ASSISTED; STATISTICS, NONPARAMETRIC; UTERINE CERVICAL NEOPLASMS;

EID: 16944363731     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Parkin, D. M., Pisani, P., and Ferlay, J. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int. J. Cancer, 54: 594-606, 1993.
2. Mitchell, M. F., Hittelman, W. K., Lotan, R., Nishioka, K., Tortolero-Luna, G., Richards-Kortum, R., Wharton, J. T., and Hong, W. K. Chemoprevention trials and surrogate endpoint biomarkers in the cervix. Cancer (Phila.), 76: 1956-1977, 1995.
3. Mitchell, M. F., Tortolero-Luna, G., Lee, J., Hittelman, W. K., Lotan, R., Pandey, D., Wharton, J. T., Hong, W. K., and Nishioka, K. Results of a Phase I trial of α-difluoromethylornithine in patients with cervical intraepithelial neoplasia. Gynecol. Oncol., 60: 101, 1996.
4. Pegg, A. E. Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy. Cancer Res., 48: 759-774, 1988.
5. Marton, L. J., and Pegg, A. E. Polyamines as targets for therapeutic intervention. Annu. Rev. Phamacol. Toxicol., 35: 55-91, 1995.
6. Tabor, H., and Tabor, C. W. Polyamines. Annu. Rev. Biochem., 53:749-790, 1984.
7. Basu, H. S., Sturkenboom, M. C. J., Delcros, J. G., Csokan, P. P., and Szollosi, J. Effect of polyamine depletion on chromatin structure in U-87 MG human brain tumour cells. Biochem. J., 282: 723-727, 1992.