Psychological distress in applicants for predictive DNA testing for autosomal dominant, heritable, late onset disorders

Journal of Medical Genetics

Volumn 34, Issue 5, 1997, Pages 382-390

  DudokdeWit, A C ^d,e   Tibben, A ^a,d   Duivenvoorden, H J ^d   Frets, P G ^a,d   Zoeteweij, M W ^d,e   Losekoot, M ^e   Van Haeringen, A ^e   Niermeijer, M F ^a   Passchier, J ^d   Lindhout, D ^a   Meijers Heijboer, E J ^a   Lodder, L N ^a   Trijsburg, R W ^a   Klijn, J G M ^a   Brocker Vriends A ^b   Helderman, A T J M ^b   Hilhorst Hofstee, Y ^b   Kant, S ^b   Maat Kievit, J A ^b   Oosterwijk, J C ^b   Van Der Smagt, J J ^b   Vegter van Der Vlis, M ^b   Vries van Der Weerd, M A C S ^b   Bakker, E ^b   Cornelisse, C J ^b   Devilee, P ^b   Tops, C ^b   Vasen, H F A ^c   more..

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Dept Med Psychol and Psychother ^*  (Netherlands)

^c Dutch Found of Hereditary Tumours   (Netherlands)

^d ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Hereditary cancer syndromes; Hereditary neurodegenerative disorders; Pre test psychological distress; Predictive DNA testing

Indexed keywords

DNA;

ADULT; ARTICLE; AUTOSOMAL DOMINANT DISORDER; AVOIDANCE BEHAVIOR; BRAIN HEMORRHAGE; BREAST CANCER; COLON POLYPOSIS; DENIAL; DISTRESS SYNDROME; DNA DETERMINATION; FEMALE; GENETIC COUNSELING; HEALTH CARE PERSONNEL; HETEROZYGOTE; HUMAN; HUNTINGTON CHOREA; MAJOR CLINICAL STUDY; MALE; NERVE DEGENERATION; OVARY CANCER; PRIORITY JOURNAL; RELATIVE; RISK;

BRAIN PATHOLOGY; BREAST CANCER; CANCER; CLINICAL APPROACH/SOURCE; EMPIRICAL APPROACH; FAMILY MEMBERS; GENETICS AND REPRODUCTION; LATE-ONSET DISORDERS; NETHERLANDS; STIGMATIZATION;

ADENOMATOUS POLYPOSIS COLI; ADOLESCENT; ADULT; AGE OF ONSET; BRAIN DISEASES; BREAST NEOPLASMS; CEREBRAL HEMORRHAGE; CHROMOSOME ABERRATIONS; CHROMOSOME DISORDERS; DNA; FEMALE; GENETIC DISEASES, INBORN; HETEROZYGOTE; HETEROZYGOTE DETECTION; HUMANS; HUNTINGTON DISEASE; MALE; MIDDLE AGED; OVARIAN NEOPLASMS; PREDICTIVE VALUE OF TESTS; RISK FACTORS; SEXUAL PARTNERS; STRESS, PSYCHOLOGICAL;

EID: 16944363057     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993;72:971-83.
2. Brook JD, McCurrach ME, Harley HG, et al. Molecular basis of myotonic dystrophy: expansion of a trinucleotide (CTG) repeat at the 3′ end of a transcript encoding a protein kinase family member. Cell 1992;68:799-808.
3. Bird TD. Familial Alzheimer's disease. Ann Neurol 1994;36:335-6.
4. Haltia M, Viitanen M, Sulkava R, et al. Chromosome 14-encoded Alzheimer's disease: genetic and clinicopathological description. Ann Neurol 1994;36:362-7.
5. Bakker E, van Broeckhoven C, Haan J, et al. DNA diagnosis for hereditary cerebral hemorrhage with amyloidosis (Dutch type). Am J Hum Genet 1991;49:518-21.
6. Wooster R, Neuhausen SL, Mangion J, et al. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science 1994;265:2088-90.
7. Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994;266:66-71.
8. Kinzler KW, Nilbert MC, Su LK, et al. Identification of FAP locus genes from chromosome 5q21. Science 1991;253:661-5.
9. Groden J, Thliveris A, Samowitz W, et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell 1991;66:589-600.
10. Wijnen J, Vasen H, Khan PM, et al. Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradient-gel electrophoresis. Am J Hum Genet 1995;56:1060-6.