Preclinical evaluation of the antidiabetic effect of Eugenia jambolana seed powder in streptozotocin-diabetic rats

Brazilian Journal of Medical and Biological Research

Volumn 38, Issue 3, 2005, Pages 463-468

  Sridhar, S B ^a   Sheetal, U D ^a   Pai, M R S M ^a   Shastri, M S ^b  

^a KASTURBA MEDICAL COLLEGE   (India)

^b MV Shastri and Sons   (India)

Author keywords

Antidiabetic effect; Diabetes; Eugenia jambolana seed; Liver glycogen; Preclinical data; Toxicity studies

Indexed keywords

ANTIDIABETIC AGENT; GALLIC ACID; GLUCOSE; GLYCOGEN; HERBACEOUS AGENT; OXALIC ACID; STREPTOZOCIN; SYZYGIUM CUMINI EXTRACT; TANNIN; TERPENOID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES CONTROL; DIABETES MELLITUS; DIET RESTRICTION; DRUG MECHANISM; EUGENIA; EUGENIA JAMBOLANA; FEMALE; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PLANT SEED; RAT; RAT STRAIN; STREPTOZOCIN DIABETES; TREATMENT OUTCOME; WEIGHT GAIN;

ANIMALIA; EUGENIA; RATTUS NORVEGICUS; SYZYGIUM CUMINI;

EID: 16844368848     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2005000300018     Document Type: Article

References (16)

1. Grover JK, Yadav S & Vats V (2002). Medicinal plants of India with anti-diabetic potential. Journal of Ethnopharmacology, 81: 81-100.
2. World Health Organization (1980). WHO Expert Committee on Diabetes Mellitus Second Report. Technical Report Series, 646: 61.
3. Teixeira CC, Fuchs FD, Blotta RM, Da Costa AP, Mussnich DG & Ranquetat GG (1992). Plants employed in the treatment of diabetes mellitus: results of an ethnopharmacological survey in Porto Alegre, Brazil. Fitoterapia, 63: 320-322.
4. Pepato MT, Folgado VBB, Kettelhut IC & Brunetti IL (2001). Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes. Brazilian Journal of Medical and Biological Research, 34: 389-395.
5. Trinder P (1969). Determination of glucose using glucose oxidase with an alternative oxygen acceptor. Annals of Clinical Biochemistry, 6: 24-27.
6. Hassid WZ & Abraham S (1960). Determination of glycogen by modified Pfliiger method. In: Sydney PC & Nathan OK (Editors), Methods in Enzymology. Vol. 111. 2nd edn. Academic Press, New York, 34-36.
7. Prince PSM, Manon VP & Pari L (1998). Hypoglycemic activity of Syzigium cumini seeds: effect on lipid peroxidation in alloxan diabetic rats. Journal of Ethnopharmacology, 61: 1-7.
8. Sharma SB, Nasir A, Prabhu KM, Murthy PS & Dev G (2003). Hypoglycemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. Journal of Ethnopharmacology, 85: 201-206.
9. Kedar P & Chakrabarti CH (1983). Effects of jambolan seed treatment on blood sugar, lipids and urea in streptozotocin induced diabetes in rabbits. Indian Journal of Physiology and Pharmacology, 27: 136-140.
10. Grover JK, Vats V, Rathi SS & Dawar R (2001). Traditional Indian anti-diabetic plants attenuate progression of renal damage in streptozotocin induced diabetic mice. Journal of Ethnopharmacology, 76: 233-238.
11. Vats V, Grover JK, Tandon N, Rathi SS & Gupta N (2001). Treatment with extracts of Momordica charantia and Eugenia jambolana prevents hyperglycemia and hyperinsulinemia in fructose fed rats. Journal of Ethnopharmacology, 76: 139-143.
12. The Himalaya Drug Company (2004). Himalaya Herbal Healthcare. Herbal Monograph page [http://www.himalayahealthcare.com/herbfinder/h_syzygi.htm]. Accessed July 20, 2004.
13. Pioneer Enterprise (2004). Phytonutrients and Standardized Herbal extracts page [http://www.pioneerherbs.com/eugenia_jambolana.htm]. Accessed July 20, 2004.
14. Achrekar S, Kaklij GS, Pote MS & Kelkar SM (1991). Hypoglycemic activity of Eugenia jambolana and Ficus bengalensis mechanism of action. In Vivo, 5: 143-148.
15. Bansal R, Ahmad N & Kidwai JR (1981). Effect of oral administration of Eugenia jambolana seeds and chlorpropamide on blood glucose level and pancreatic cathepsin B in rat. Indian Journal of Biochemistry and Biophysics, 18: 377.
16. Pradeep R & Mohan V (2002). The changing scenario of the diabetes epidemic: implications for India. Indian Journal of Medical Research, 116: 121-132.