Direct pallatization in a rotary processor controlled by torque measurements. II: Effects of changes in the content of microcrystalline cellulose

AAPS PharmSci

Volumn 2, Issue 3, 2000, Pages 1-8

  Kristensen, Jakob ^a   Schæfer, Torben ^a   Kleinebudde, Peter ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 16844365213     PISSN: 15221059     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Vecchio C, Bruni G, Gazzaniga A. Preparation of indobufen pellets by using centrifugal rotary fluidized bed equipment without starting seeds. Drug Dev Ind Pharm. 1994;20:1943-1956.
2. Fielden KE, Newton JM. Extrusion and extruders. In: Swarbrick J, Boylan JC, eds. Encyclopedia of Pharmaceutical Technology. Vol. 5. New York: Marcel Dekker; 1992;395-442.
3. Vertommen J, Kinget R. Influence of five selected processing and formulation variables on the particle size, particle size distribution, and friability of pellets produced in a rotary processor. Drug Dev Ind Pharm. 1997;23:39-46.
4. Holm P, Bonde M, Wigmore T. Pelletization by granulation in a roto-processor RP-2. Part 1. Effects of process and product variables on granule growth. Pharm Technol Eur. 1996;8:22-36.
5. Kristensen J, Schaefer T, Kleinebudde P. Direct pelletization in a rotary processor controlled by torque measurements. I: Influence of process variables. Pharm Dev Technol. 2000;5:247-256.
6. Robinson RL, Hollenbeck RG. Manufacture of spherical acetaminophen pellets: comparison of rotary processing with multiple-step extrusion and spheronization. Pharm Technol. 1991;15:48-56.
7. Sienkiewicz G, Pereira R, Rudnic EM, Lausier JM, Rhodes CT. Spheronization of theophylline-avicel combinations using a fluidized-bed rotogranulation technique. Drug Dev Ind Pharm. 1997;23:173-182.
8. Holm P. Pelletization by granulation in a roto-processor RP-2. Part 2. Effects of process and product variables on agglomerates' shape and porosity. Pharm Technol Eur. 1996;8:38-45.
9. Vertommen J, Rombaut P, Kinget R. Shape and surface smoothness of pellets made in a rotary processor. Int J Pharm. 1997;146:21-29.
10. Heng PW, Wan LS, Tan YT. Optimization of spheroid production by centrifugal rotary processing. Int J Pharm. 1996;143:107-112.
11. Vertommen J, Jaucot B, Rombaut P, Kinget R. Improvement of the material motion in a rotary processor. Pharm Dev Technol. 1996;1:365-371.
12. Wan LS, Heng PW, Liew CV. The role of moisture and air gap pressure in the formation of spherical granules by rotary processing. Drug Dev Ind Pharm. 1994;20:2551-2561.
13. Holm P. Pelletization by granulation in a roto-processor RP-2. Part 3. Methods of process control and the effect of microcrystalline cellulose on wet granulation. Pharm Technol Eur. 1996;8:36-46.
14. Vertommen J, Rombaut P, Michoel A, Kinget R. Estimation of the amount of water removed by gap and atomization air streams during pelletization in a rotary processor. Pharm Dev Technol. 1998;3:63-72.
15. Schaefer T, Mathiesen C. Melt pelletization in a high shear mixer. VIII. Effects of binder viscosity. Int J Pharm. 1996;139:125-138.
16. Wan LS, Heng PW, Liew CV. Spheronization conditions on spheroid shape and size. Int J Pharm. 1993;96:59-65.
17. Bains D, Boutell SL, Newton JM. The influence of moisture content on the preparation of spherical granules of barium sulphate and microcrystalline cellulose. Int J Pharm. 1991;69:233-237.
18. Gazzaniga A, Sangalli ME, Bruni G, Zema L, Vecchio C, Giordano F. The use of β-cyclodextrin as a pelletization agent in extrusion/spheronization process. Drug Dev Ind Pharm. 1998;24:869-873.
19. Kleinebudde P, Solvberg AJ, Lindner H. The power-consumption-controlled extruder: a tool for pellet production. J Pharm Pharmacol. 1994;46:542-546.
20. Kleinebudde P, Schroder M, Schultz P, Muller BW, Waaler T, Nymo L. Importance of the fraction of microcrystalline cellulose and spheronization speed on the properties of extruded pellets made from binary mixtures. Pharm Dev Technol. 1999;4:397-404.
21. Thoma R, Ziegler I. Investigation of the influence of the type of extruder for pelletization by extrusion-spheronization. II. Sphere characteristics. Drug Dev Ind Pharm. 1998;24:413-422.
22. Schmidt C, Kleinebudde P. Significance of the granulation step in pelletization by extrusion/spheronization. Chem Pharm Bull. 1999;47:405-412.
23. Kleinebudde P. Shrinking and swelling properties of pellets containing microcrystalline cellulose (MCC) and low substituted hydroxypropylcellulose (L-HPC). Part I. Shrinking properties. Int J Pharm. 1994;109:209-219.