Ventajas de asociar inhibidores del daño por isquemia/reperfusión a la trombólisis intravenosa en el tratamiento de la isquemia cerebral focal. Descripción de un modelo experimental en ratas

Revista de Neurologia

Volumn 24, Issue 126, 1996, Pages 207-213

  De Leciñana, M Alonso ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

Brain ischemia; Cytoprotection; Ischemia reperfusion injury; Plasminogen tissue activator; Thrombolysis

Indexed keywords

ANTIOXIDANT; CALCIUM CHANNEL BLOCKING AGENT; FIBRINOLYTIC AGENT; FREE RADICAL;

ANIMAL; ARTICLE; BRAIN; BRAIN ISCHEMIA; CAROTID ARTERY; COMPARATIVE STUDY; DRUG EFFECT; MALE; PATHOPHYSIOLOGY; RAT; VASCULARIZATION;

ANIMALS; ANTIOXIDANTS; BRAIN; BRAIN ISCHEMIA; CALCIUM CHANNEL BLOCKERS; CAROTID ARTERIES; FIBRINOLYTIC AGENTS; FREE RADICALS; MALE; RATS;

EID: 16744365113     PISSN: 02100010     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Díez-Tejedor E, Alonso de Lecinana M. ¿Es el infarto cerebral una urgencia médica tratable y una catástrofe prevenible? Sístole, 1994; 162: 3.
2. Camarata PJ, Heros RC, Latchaw RE. Brain attack: the rationale for treating Stroke as a medical emergency. Neurosurgery 1994; 34: 144-158.
3. Indredavik B, Bakke F. Benefit of a Stroke Unit: a randomized controlled Trial. Stroke 1991; 22: 1026-1031.
4. Díez-Tejedor E, Hachinski VC. Unidades de Ictus. ¿Son realmente beneficiosas? Rev Clin Esp 1993; 193: 347-349.
5. Langhorne P, Williams BO, Gilchrist W, Howie K. Do Stroke Units save lives? Lancet 1993; 342: 395-398.
6. Alonso de Leciñana M, Díez-Tejedor E, Frank A, Barreiro P. Guía para el manejo del paciente con enfermedad vascular cerebral aguda. Rev Neurol (Bare) 1995; 23: 363-369..
7. Adams HP, Brott TG, Crowell RM, et al. Guidelines for the management of patients with acute ischemic stroke. Stroke 1904, 25: 1901-1914.
8. Sandercock P, Willems H. Medical treatment of acute ischemic stroke. Lancet 1992, 339: 537-539.
9. Alonso de Leciñana M, Díez-Tejedor E, Barreiro P, Hachinski VC. Tratamiento de infarto cerebral agudo. Rev Clin Esp (Numero monográfico en prensa).
10. Hossmann KA. Viability thresholds and the penumbra of focal ischemia. Ann Neurol 1994; 36: 557-565.
11. Ginsberg MD, Pulsinelli WA. The ischemic penumbra, injury thresholds and the therapeutic window for acute stroke. Ann Neurol 1994; 36: 553-554.
12. Alonso de Leciñana M, Díez-Tejedor E, Frank A. Fisiopatología de la isquemia cerebral. En Castillo J, Martínez-Vila E, eds. Trombosis, fármacos antitrombóticos y enfermedad cerebrovascular. Barcelona: J. Uriach y Cia, SA, 1995; 413-425.
13. Siesjö BK. Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology. J Neurosurg 1992; 77: 169-184.
14. Siesjö BK. Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment. J Neurosurg 1992; 77: 337-354.
15. Babbs CF. Reperfusion injury of postischemic tissues. Ann Emerg Med 1988; 17: 1148-1157.
16. Betz AL. Therapeutic window. Stroke 1993; 24 (Suppl 1): 38-40.
17. Pulsinelli WA. The therapeutic window in ischemic brain injury. Current opinion in Neurology 1995; 8: 3-5.
18. Lyden PD, Zivin JA, Clark WA, et al. Tissue plasminogen activator-mediated thrombolysis of cerebral emboli and its effect on hemorrhagic infarction in rabbits. Neurology 1989; 39: 703-708.
19. Overgaard K, Sereghy T, Boysen G, et al. Reduction of infarct volume and mortality by thrombolysis in a rat embolic stroke model. Stroke 1992; 23: 1167-1174.
20. Wardlaw JW, Warlow CP. Thrombolysis in acute ischemic stroke: does it work? Stroke 1992; 23: 1826-1839.