Drying effects on residual moisture of lyophilization rubber closures

PDA Journal of Pharmaceutical Science and Technology

Volumn 58, Issue 5, 2004, Pages 250-253

  Kruszynski, Mark ^a   Tempel, Jessica ^b   Akers, Michael J ^a  

^a Baxter Pharmaceutical Solutions LLC   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOBUTYL DERIVATIVE; BUTYL DERIVATIVE; CHLOROBUTYL DERIVATIVE; ELASTOMER; RUBBER; STELMI 6803 SERUM; STELMI 6806 LYO; STELMI 6811; STELMI CT802; UNCLASSIFIED DRUG; WEST 061; WEST 095; WEST 217; WEST 219; WEST 273; WEST S87; WEST V50 LYO;

ACCURACY; ARTICLE; AUTOCLAVE; DRUG FORMULATION; DRUG STERILITY; FREEZE DRYING; MOISTURE; POWDER; TEMPERATURE DEPENDENCE; VACUUM; WATER VAPOR; DRUG PACKAGING; METHODOLOGY; PHARMACEUTICS;

DRUG PACKAGING; FREEZE DRYING; RUBBER; TECHNOLOGY, PHARMACEUTICAL;

EID: 16644403681     PISSN: 10797440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (3)

1. nd ed; Rey, L., May, J. C., Eds.; Marcel Dekker: New York, 2004; pp 320-322.
2. Wang, Z.; Frankel, B. A.; Lambert, W. J. Determination of Moisture in Rubber Stoppers: Effect of Karl Fischer Oven Temperatures. PDA J. Pharm. Sci. Technol. 55, 162-170 (2001).
3. Templeton, A. C.; Placek, J.; Xu, H.; Mahajan, R.; Hunke, W. A.; and Reed, R. A., "Determination of the Moisture Content of Bromobutyl Rubber Stoppers as a Function of Processing: Implications for the Stability of Lyophilized Products", PDA J. Pharm. Sci. Technol., 57, 75-87 (2003).