Phase II study of cisplatin and 5-fluorouracil with concurrent radiotherapy in advanced squamous cell carcinoma of the esophagus: A Japan esophageal oncology group (JEOG)/Japan clinical oncology group trial (JCOG9516)

Japanese Journal of Clinical Oncology

Volumn 34, Issue 10, 2004, Pages 615-619

  Ishida, Kaoru ^a   Ando, Nobutoshi ^b   Yamamoto, Seiichiro ^c   Ide, Hiroko ^d   Shinoda, Masayuki ^e  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b TOKYO DENTAL COLLEGE   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^d Hamacyo Center Bill Clinic   (Japan)

^e AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

5 Fluorouracil; Chemoradiotherapy; Cisplatin; Esophageal cancer; Phase II study

Indexed keywords

CISPLATIN; FLUOROURACIL; ANTINEOPLASTIC AGENT; CF REGIMEN;

ADULT; ADVANCED CANCER; AGED; ALOPECIA; ARTICLE; BLEEDING DISORDER; BLOOD TOXICITY; BONE MARROW SUPPRESSION; CANCER INCIDENCE; CANCER PATIENT; CANCER REGISTRY; CLINICAL OBSERVATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DRUG DOSE REGIMEN; DRUG FATALITY; DRUG INFUSION; DYSPNEA; ESOPHAGITIS; ESOPHAGUS CARCINOMA; FEMALE; FEVER; FISTULA; HUMAN; INFECTION; JAPAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MEDICAL SOCIETY; NAUSEA AND VOMITING; ONCOLOGY; PHASE 2 CLINICAL TRIAL; RADIATION DOSE; SEPSIS; SQUAMOUS CELL CARCINOMA; STOMATITIS; SURVIVAL RATE; SURVIVAL TIME; THORAX TUMOR; THROMBOCYTOPENIA; CHEMICALLY INDUCED DISORDER; DRUG ADMINISTRATION; ESOPHAGUS TUMOR; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; NAUSEA; VOMITING;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, SQUAMOUS CELL; CISPLATIN; COMBINED MODALITY THERAPY; DRUG ADMINISTRATION SCHEDULE; ESOPHAGEAL NEOPLASMS; ESOPHAGITIS; FEMALE; FLUOROURACIL; HUMANS; MALE; MIDDLE AGED; NAUSEA; RADIOTHERAPY DOSAGE; SURVIVAL RATE; VOMITING, ANTICIPATORY;

EID: 16644401422     PISSN: 03682811     EISSN: None     Source Type: Journal    
DOI: 10.1093/jjco/hyh107     Document Type: Article

References (11)

1. Herskovic A, Martz K, al-Sarraf M, Leichman L, Brindle J, Vaitkevicius V, et al. Combined chemothempy and radiotherapy compared with radiothempy alone in patients with cancer of the esophagus. N Engl J Med 1992;326:1593-8.
2. Ishida K, Iizuka T, Ando N, Ide H. Phase II study of chemoradiotherapy for advanced squamous cell carcinoma of the thoracic esophagus: nine Japanese institutions trial. Jpn J Clin Oncol 1996;26:310-5.
3. Guidelines for the Clinical and Pathologic Studies on Carcinoma of the Esophagus, 8th edn. Japanese Society for Esophageal Disease. Kanehara & Co. Ltd. 1992.
4. Simon R. Design and analysis of clinical trials. In: DeVita VT, Hellman S, Rosenberg SA, editors. Cancer: Principles and Practice of Oncology, 6th edn. Philadelphia: Lippincott Williams and Wiillkins 2001;521-38.
5. Armitage P, Berry G. Survival analysis. In: Statistical Methods in Medical Research, 3rd edn. Oxford: Blackwell 1994;469-92.
6. Tobinai K, Kohno A, Shimada Y, Watanabe T, Tamura T, Takeyama K, et al. Toxicity grading criteria of the Japan Clinical Oncology Group. The Clinical Trial Review Committee of the Japan Clinical Oncology Group. Jpn J Clin Oncol 1993;23:250-7.
7. Ohtsu A, Boku N, Muro K, Chin K, Muro M, Yoshida S, et al. Definitive chemoradiotherapy for T4 and/or M1 lymph node squamous cell carcinoma of the esophagus. J Clin Oncol 1999;17:2915-21.
8. Nishimura Y, Suzuki M, Nakamatsu K, Kanamori S, Yagyu Y, Shigeoka H. Prospective trial of concurrent chemomdiotherapy with protracted infusion of 5-fluorouracil and cisplatin for T4 esophageal cancer with or without fistula, lnt J Radiat Oncol Phys 2002;53:134-9.
9. John M, Flam M, Wittlinger P, Mowry PA. Inoperable esophageal carcinoma: results of aggressive synchronous radiotherapy and chemotherapy. A pilot study. Am J Clin Oncol 1987;10:310-6.
10. Calais G, Dorval E, Louisot P, Bourlier P, Klein V, Chapet S, et al. Radiotherapy with high dose rate brachytherapy boost and concomitant chemothempy for Stages IIB and III esophageal carcinoma: results of a pilot study, lnt J Radiat Oncol Biol Phys 1997;38:769-7.
11. Gaspar LE, Winter K, Kocha WI, Coia LR, Herskovic A, Graham M. A phase I/II study of external beam radiation, brachytherapy and concurrent chemotherapy for patients with localized carcinoma of the esophagus (Radiation Therapy Oncology Group Study 9207): final report. Cancer 2000;88:988-95.