Separation of blood cells and plasma in microchannel bend structures

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 5591, Issue , 2004, Pages 143-151

  Blattert, C ^a   Jurischka, R ^a   Schoth, A ^a,c   Kerth, P ^b   Menz, W ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b Preventor TBC GmbH   (Germany)

^c Lehrstuhl fuer Prozesstechnologie   (Germany)

Author keywords

Bend; Blood; Disposable; Hot embossing; Lab on the chip; Microchannel; Microfluidic; Rapid prototyping; Separation; UV LIGA

Indexed keywords

BIOASSAY; CELLS; COMPUTATIONAL GEOMETRY; MICROPROCESSOR CHIPS; PLASMAS; RAPID PROTOTYPING; SEPARATION; ULTRAVIOLET RADIATION; VELOCITY MEASUREMENT;

BEND; DISPOSABLE; HOT EMBOSSING; LAB-ON-THE-CHIP; MICROCHANNEL; MICROFLUIDICS; UV-LIGA;

BLOOD;

EID: 16644400440     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.568823     Document Type: Conference Paper

References (21)

1. K. Sawada, P.S. Malchesky, and Y. Nose, Available Removal Systems: State of the Art, Curr. Stud. Hematol. Blood. Transf., Basel, Karger, No. 57, 1990, pp. 51-113
2. Major advances via miniaturisation, in Innovation - our key to success, Roche R & D Media Day, F. Hoffman-La Roche Ltd., 2002
3. B. He, L. Tan, and F. Regnier, Microfabricated Filters for Microfluidic Analytical Systems, Analytical Chemistry, Vol. 71, No. 7, 1999, pp. 1464-1468
4. P.K. Yuen, L.J. Kricka, P. Fortina, N.J. Panaro, T. Sakazume and P. Wilding, Microchip Module for Blood Sample Preparation and Nucleic Acid Amplification Reactions, Genome Research, 11, 2001, pp.405-412
5. B.H. Weigl and P. Yager, Microfluidic Diffusion-Based Separation and Detection, Science, 283 (5400), 1999, pp. 346-347
6. P.M. Martin, D.W. Matson, W.D. Bennett, Y. Lin, and D.J. Hammerstrom, Laminated Plastic Microfluidic Components for Biological and Chemical Systems, J. Vac. Sci. Technol. A, 17(4), 1999, pp. 2264-2269
7. M.J. Madou, L.J. Lee, S. Daunert, S. Lai, and C-H. Shih, Design and Fabrication of CD-like Microfluidic Platforms for Diagnostics: Microfluidic Functions, Biomedical Microdevices, 3:3, 2001, pp. 245-255
8. A. Schoth, C. Blattert, W. Menz, S. Meyer, and H. Oertel, Verfahren zur Trennung von Suspensionen und Vorrichtung, patent WO 03/031015 A1, April 17, 2003
9. E. Becker et al., Production of Separation Nozzle Systems for Uranium Enrichment by a Combination of X-Ray Lithography and Galvanoplastics, Naturwissenschaften, 69, 1982, pp. 520-523
10. K. Svanes, and B.W. Zweifach, Variations in Small Blood Vessel Hematocrits Produced in Hypothermic Rats by Micro-Occlusion, Microvascular Research, 1, 1968, pp. 210-220
11. R.T. Yen, and Y.C. Fung, Effect of Velocity Distribution on Red Cell Distribution in Capillary Blood Vessels, Am. J. Physiol.: Heart Circ. Physiol., 4(2), 1978, pp. H251-H257
12. R. Ditchfield, and W.L. Olbricht, Effects of Particle Concentration on the Partitioning of Suspensions at Small Divergent Bifurcations, Journal of Biomechanical Engineering, 118, 1996, pp. 287-294
13. A. de Mello, Plastic Fantastic?, Lab Chip, 2, 2002, pp. N31-N36
14. J. Voldman, M.L. Gray, M.A. Schmidt, Microfabrication in Biology and Medicine, Annu. Rev. Biomed. Eng., 1, 1999, pp. 401-425
15. N-T. Nguyen, S.T.Werely; Fundamentals and Applications of Microfluidics, 2002, pp.67-136
16. C. Blattert, R. Jurischka, A. Schoth, P. Kerth, W. Menz, Separation of Blood in MicroChannel Bends, Proc. of SPIE Vol. 5345, 17, 2004, pp. 17-25
17. J.N. Mazumdar, Biofluid Mechanics. World Scientific, 1998, pp. 29-48
18. nd edition, CRC Press, 2000, pp. 1-1-1-4, 32-1-32-13
19. rd ed., Lippincott Company, 1994, pp.1211-1223
20. B.J. Van Wie and E.L. Hustvedt, Particle Interaction Effects on Blood Cell Sedimentation and Separations, in Biorheology, 25, 1988, pp. 651-662
21. A.K. Fares, Performance Evaluation of Two Haematology Analysers: the Sysmex KX-21 and the Beckman Coulter AC.T diff, Sysmex Journal International, 11(1), 2001, pp. 27-32