Prolonging QT interval and torsade de pointes in a patient with acquired human immunodeficiency virus in a multitherapy utilizing cytochrome P450;Allungamento del QT e torsione di punta in un paziente con immunodeficienza virale acquisita in multiterapia con farmaci utilizzatori del citocromo P450

Italian Heart Journal, Supplementi

Volumn 5, Issue 9, 2004, Pages 735-740

  Hrovatin, Enzo ^a   Zardo, Fabio ^a   Brieda, Marco ^a   Dametto, Ermanno ^a   Piazza, Rita ^a   Antonini Canterin, Francesco ^a   Cassin, Matteo ^a   Meneguzzo, Nereo ^b   Viel, Elda ^b   Lestuzzi, Chiara ^b   Di Gennaro, Gianpiero ^b   Nicolosi, Gian Luigi ^a  

^a UO di Cardiologia   (Italy)

^b CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

Cytochrome P450: HIV; Torsade de pointes

Indexed keywords

ANTIFUNGAL AGENT; CYTOCHROME P450; FLUCONAZOLE; METHADONE; NARCOTIC ANALGESIC AGENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; CASE REPORT; CHEMICALLY INDUCED DISORDER; DRUG COMBINATION; DRUG EFFECT; ELECTROCARDIOGRAPHY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; LONG QT SYNDROME; MALE; METHODOLOGY; OPIATE ADDICTION; PATHOPHYSIOLOGY; TORSADE DES POINTES; TREATMENT OUTCOME;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANALGESICS, OPIOID; ANTIFUNGAL AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CYTOCHROME P-450 ENZYME SYSTEM; DRUG COMBINATIONS; ELECTROCARDIOGRAPHY; FLUCONAZOLE; HUMANS; LONG QT SYNDROME; MALE; METHADONE; OPIOID-RELATED DISORDERS; TORSADES DE POINTES; TREATMENT OUTCOME;

EID: 16644393946     PISSN: 15903796     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Levy WS, Simon GL, Rios JC, Ross AM. Prevalence of cardiac abnormalities in human immunodeficiency virus infection. Am J Cardiol 1989; 63: 86-9.
2. Corallo S, Mutinelli MR, Moroni M, et al. Echocardiography detects myocardial damage in AIDS: prospective study in 102 patients. Eur Heart J 1988; 9: 887-92.
3. Acierno LJ. Cardiac complications in acquired immunodeficiency syndrome (AIDS): a review. J Am Coll Cardiol 1989; 13: 1144-54.
4. Anderson DW, Virmani R, Reilly JM, et al. Prevalent myocarditis at necropsy in the acquired immunodeficiency syndrome. J Am Coll Cardiol 1988; 11: 792-9. (Pubitemid 18092188)
5. Villa A, Foresti V, Confalonieri F. Autonomic neuropathy and prolongation of QT interval in human immunodeficiency virus infection. Clin Auton Res 1995; 5: 48-52.
6. De Ponti F, Poluzzi E, Vaccheri A, et al. Non-antiarrhythmic drugs prolonging the QT interval: considerable use in seven countries. Br J Clin Pharmacol 2002; 54: 171-7. (Pubitemid 35024941)
7. Zeltser D, Justo D, Halkin A, Prokhorov V, Heller K, Viskin S. Torsade de pointes due to noncardiac drugs: most patients have easily identifiable risk factors. Medicine (Baltimore) 2003; 82: 282-90.
8. Tholakanahalli VN, Potti A, Hanley JF, Merliss AD. Fluconazole-induced torsade de pointes. Ann Pharmacother 2001; 35: 432-4.
9. Albengres E, Le Louet H, Tillement JP. Systemic antifungal agents. Drug interactions of clinical significance. Drug Saf 1998; 18: 83-97.
10. Fantoni M, Autore C, Del Borgo C. Drugs and cardiotoxicity in HIV and AIDS. Ann NY Acad Sci 2001; 946: 179-99.
11. Mantelli L, Corti V, Vini R, Cerbai E, Ledda F. Effect of dl-methadone on the response to physiological transmitters and on several functional parameters of the isolated guinea-pig heart. Arch Int Pharmacodyn Ther 1986; 282: 298-313.
12. + currents. J Pharmacol Exp Ther 2002; 303: 688-94.
13. Lipski J, Stimmel B, Donoso E. The effect of heroin and multiple drug abuse on the electrocardiogram. Am Heart J 1973; 86: 663-8.
14. Krantz MJ, Lewkowiez L, Hays H, Wooddroffe MA, Robertson AD, Mehler PS. Torsade de pointes associated with very-high-dose methadone. Ann Intern Med 2002; 137: 501-4. (Pubitemid 35024621)
15. Krantz MJ, Kutinsky IB, Robertson AD, Melher PS. Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes. Pharmacotherapy 2003; 23: 802-5.
16. De Bels D, Staroukine M, Devriendt J. Torsades de pointes due to methadone. (letter) Ann Intern Med 2003; 139: E156.
17. Mokwe EO, Ositadinma O. Torsade de pointes due to methadone. (letter) Ann Intern Med 2003; 139: W64.
18. Walker PW, Klein D, Kasza L. High dose methadone and ventricular arrhythmias: a report of three cases. Pain 2003; 103: 321-4. (Pubitemid 36638820)
19. Gil M, Sala M, Anguera I, et al. QT prolongation and torsades de pointes in patients infected with human immunodeficiency virus and treated with methadone. Am J Cardiol 2003; 92: 995-7. (Pubitemid 37214820)
20. Kocheril AG, Bokhari SA, Batsford WP, Sinusas AJ. Long QTc and torsades de pointes in human immunodeficiency virus disease. Pacing Clin Electrophysiol 1997; 20: 2810-6.
21. Rendig SV, Amsterdam EA, Henderson GL, Mason DT. Comparative contractile actions of six narcotic analgesics: morphine, meperidine, pentazocine, fentanyl, methadone, and 1-alpha-acetylmethadol (LAAM). J Pharmacol Exp Ther 1980; 215: 259-65.
22. Kurita T, Ohe T, Shimizu W, Hotta D, Shimomura K. Early afterdepolarization in a patient with complete atrioventricular block and torsades de pointes. Pacing Clin Electrophysiol 1993; 16 (Part 1): 33-8.
23. Weskey RC Jr, Turnquest P. Torsades de pointes after intravenous adenosine in the presence of prolonged QT syndrome. Am Heart J 1992; 123: 794-6.
24. Vincent GM. Long QT syndrome. Cardiol Clin 2000; 18: 309-25.
25. Shinderman M, Maxwell S, Brawand-Amey M, Golay KP, Baumann P, Eap CB. Cytochrome P4503A4 metabolic activity, methadone blood concentrations, and methadone doses. Drug Alcohol Depend 2003; 69: 205-11. (Pubitemid 36259782)
26. Martell BA, Arnsten JH, Ray B, Gourevitch MN. The impact of methadone induction on cardiac conduction in opiate users. Ann Intern Med 2003; 139: 154-5. (Pubitemid 38129111)
27. Komthong S, Yoovathaworn K, Thithapandha A. Biphasic effect of methadone on hepatic drug metabolism. Proc Soc Exp Biol Med 1987; 184: 40-6.
28. Priori SG, Napolitano C. Genetic defects of cardiac ion channels. The hidden substrate for torsades de pointes. Cardiovasc Drugs Ther 2002; 16: 89-92.
29. Priori SG, Napolitano C, Vicentini A. Inherited arrhythmia syndromes: applying the molecular biology and genetic to the clinical management. J Interv Card Electrophysiol 2003; 9: 93-101. (Pubitemid 37441212)
30. Zareba W, Moss AJ, Sheu G, et al, for the International LQTS Registry. Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome. J Cardiovasc Electrophysiol 2003; 14: 1149-53.