Synthesis of optically active methyl 7 β-hydroxykaurenoate with potent neuroprotective activity

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 9, 2004, Pages 1153-1154

  Toyota, Masahiro ^a   Matsuura, Kiminori ^a   Yokota, Masahiro ^a   Kimura, Manami ^b   Yonaga, Masahiro ^b   Sugimoto, Hachiro ^b   Ihara, Masataka ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b EISAI CO LTD   (Japan)

Author keywords

Chiral synthesis; Kaurene diterpenoid; Neuroprotective activity; Radical cyclization

Indexed keywords

4 NORACETATE; KAURENE DERIVATIVE; METHYL 7BETA HYDROXYKAURENOATE; N METHYL DEXTRO ASPARTIC ACID; UNCLASSIFIED DRUG; DITERPENE; METHYL 7 BETA HYDROXYKAURENOATE; METHYL 7 BETA HYDROXYKAURENOATE 4 DEMETHYL ACETATE; METHYL 7 BETA-HYDROXYKAURENOATE; METHYL 7 BETA-HYDROXYKAURENOATE 4-DEMETHYL ACETATE; N METHYLASPARTIC ACID; NEUROPROTECTIVE AGENT;

ARTICLE; BRAIN CELL; CELL CULTURE; CYCLIZATION; DIELS ALDER REACTION; DRUG POTENCY; DRUG SYNTHESIS; NEUROPROTECTION; ANIMAL; CHEMICAL STRUCTURE; DRUG ANTAGONISM; SYNTHESIS;

ANIMALS; CELLS, CULTURED; DITERPENES; MOLECULAR STRUCTURE; N-METHYLASPARTATE; NEUROPROTECTIVE AGENTS;

EID: 16644392977     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.52.1153     Document Type: Article

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