Immunofluorescence localization of prolyl 4-hydroxylase isoenzymes and type I and II collagens in bone tumours: Type I enzyme predominates in osteosarcomas and chondrosarcomas, whereas type II enzyme predominates in their benign counterparts

Acta Histochemica

Volumn 106, Issue 2, 2004, Pages 111-121

  Nissi, Ritva ^a   Bohling, Tom ^b   Autio Harmainen, Helena ^a  

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Chondrocytes; Collagens; Immunofluorescence; Osteoblasts; Primary bone tumours; Prolyl 4 hydroxylase

Indexed keywords

BONE; CELLS; COLLAGEN; ENZYME KINETICS; FLUORESCENCE; POLYPEPTIDES; TUMORS;

CHONDROCYTES; IMMUNOFLUORESCENCE; OSTEOBLASTS; PRIMARY BONE TUMORS; PROLYL 4-HYDROXYLASE;

IMMUNOLOGY;

COLLAGEN TYPE 1; COLLAGEN TYPE 2; ISOENZYME; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; TUMOR MARKER;

ADULT; AGED; ANIMAL CELL; ARTICLE; BENIGN TUMOR; BONE TUMOR; CHONDROSARCOMA; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LOCALIZATION; ENZYME SUBUNIT; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; MALE; NONHUMAN; OSTEOSARCOMA; PROTEIN EXPRESSION; RAT; ANIMAL; BIOSYNTHESIS; CELL DIFFERENTIATION; CHORDOMA; ENZYMOLOGY; FIBROUS DYSPLASIA; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; PREDICTION AND FORECASTING; TUMOR CELL LINE;

ANIMALS; BONE NEOPLASMS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CHONDROSARCOMA; CHORDOMA; COLLAGEN TYPE I; COLLAGEN TYPE II; FIBROUS DYSPLASIA OF BONE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; ISOENZYMES; MICROSCOPY, FLUORESCENCE; OSTEOSARCOMA; PREDICTIVE VALUE OF TESTS; PROCOLLAGEN-PROLINE DIOXYGENASE; RATS; TUMOR MARKERS, BIOLOGICAL;

EID: 16644377784     PISSN: 00651281     EISSN: 16180372     Source Type: Journal    
DOI: 10.1016/j.acthis.2003.12.002     Document Type: Article

References (18)

1. Aigner T, Loos S, Inwards C, Perris R, Perissinotto D, Unni KK, Kirchner T. Chondroblastoma is an osteoidforming, but not cartilage-forming neoplasm. J Pathol 1999;189:463-9.
2. Aigner T, Loos S, Muller S, Sandell LJ, Unni KK, Kirchner T. Cell differentiation and matrix gene expression in mesenchymal chondrosarcomas. Am J Pathol 2000;156:1327-35.
3. 2 tetramer. J Biol Chem 1997;272:17342-8.
4. Annunen P, Autio-Harmainen H, Kivirikko KI. The novel type II prolyl 4-hydroxylase is the main enzyme form in chondrocytes and capillary endothelial cells, whereas the type I enzyme predominates in most cells. J Biol Chem 1998;273:5989-92.
5. Corral DA, Amling M, Priemel M, Loyer E, Fuchs S, Ducy P, Baron R, Karsenty G. Dissociation between bone resorption and bone formation in osteopenic transgenic mice. Proc Nat Acad Sci USA 1998;95: 13835-40.
6. Desbois C, Hogue DA, Karsenty G. The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression. J Biol Chem 1994;269:1183-90.
7. 2 tetramer with the protein disulfide-isomerase/β sub-unit. Proc Nat Acad Sci USA 1995;92:4427-31.
8. Kivirikko KI, Myllyharju J. Prolyl 4-hydroxylases and their protein disulfide isomerase subunit. Matrix Biol 1998;16:357-68.
9. Kivirikko KI, Pihlajaniemi T. Collagen hydroxylases and the protein disulfide isomerase subunit of prolyl 4-hydroxylases. Adv Enzymol Relat Areas Mol Biol 1998;72:325-98.
10. Myllyharju J, Kivirikko KI. Collagens and collagen-related diseases. Ann Med 2001;33:7-21.
11. Nissi R, Autio-Harmainen H, Marttila P, Sormunen R, Kivirikko KI. Prolyl 4-hydroxylase isoenzymes I and II have different expression patterns in several tissues. J Histochem Cytochem 2001;49:1143-53.
12. Pihlajaniemi T, Helaakoski T, Tasanen K, Myllylä R, Huhtala ML, Koivu J, Kivirikko KI. Molecular cloning of the α subunit of human prolyl 4-hydroxylase. This subunit and protein disulphide isomerase are products of the same gene. EMBO J 1987;6:643-9.
13. Prockop DJ, Kivirikko KI. Collagens: molecular biology, diseases, and potentials for therapy. Annu Rev Biochem 1995;64:403-34.
14. Roach HI, Erenpreisa J, Aigner T. Osteogenic differentiation of hypertrophic chondrocytes involves asymmetric cell divisions and apoptosis. J Cell Biol 1995;131:483-94.
15. Shapiro FD, Eyre DR. Collagen polymorphism in extracellular matrix of human osteosarcoma. J Nat Cancer Ilnst 1982;69:1009-16.
16. Van Den Diepstraten C, Papay K, Bolender Z, Brown Am And Pickering JG. Cloning of a novel prolyl 4-hydroxylase subunit expressed in the fibrous cap of human atherosclerotic plaque. Circulation 2003;108:508-11.
17. Vincent F, Corral M, Defer N, Adolphe M. Effects of oxygen free radicals on articular chondrocytes in culture: c-myc and c-Ha-ras messenger RNAs and proliferation kinetics. Exp Cell Res 1991; 192: 333-9.
18. Vuori K, Pihlajaniemi T, Myllylä R, Kivirikko KI. Site-directed mutagenesis of human protein disulphide isomerase: effect on the assembly, activity and endoplasmic reticulum retention of human prolyl 4-hydroxylase in spodoptera frugiperda insect cells. EMBO J 1992; 11: 4213-7.