Potential regulation of nuclear UDP-N-acetylglucosaminyl transferase (OGT) by substrate availability: Ability of chromatin protein to bind UDP-N-acetylglucosamine and reduce OGT-mediated O-linked glycosylation

Biological and Pharmaceutical Bulletin

Volumn 27, Issue 8, 2004, Pages 1293-1296

  Okuyama, Ryo ^a   Marshall, Stephen ^a  

^a Hexos Inc   (United States)

Author keywords

Chromatin; Enzyme; Subcellular fractionation; Substrate avalavility; UDP N acetylglucosaminyl transferase

Indexed keywords

BINDING PROTEIN; CELL NUCLEUS DNA; ENZYME; PROTEIN; TRITON X 114; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GALACTOSE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE TRANSFERASE; N ACETYLGLUCOSAMINE; N ACETYLGLUCOSAMINYLTRANSFERASE; N ACETYLLACTOSAMINIDE BETA 1,6 N ACETYLGLUCOSAMINYLTRANSFERASE; N-ACETYLLACTOSAMINIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE;

ANIMAL TISSUE; ARTICLE; CHROMATIN; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME INACTIVATION; GLYCOSYLATION; NONHUMAN; RAT; ANIMAL; CELL NUCLEUS; ENZYME SPECIFICITY; ENZYMOLOGY; ISOLATION AND PURIFICATION; METABOLISM;

ACETYLGLUCOSAMINE; ANIMALS; CELL NUCLEUS; GLYCOSYLATION; N-ACETYLGLUCOSAMINYLTRANSFERASES; RATS; SUBSTRATE SPECIFICITY;

EID: 16644370669     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.27.1293     Document Type: Article

References (16)

1. Torres C.-R., Hart G. W., J. Biol. Chem., 259, 3308-3317 (1984).
2. Holt G. D., Hart G. W., J. Biol. Chem., 261, 8049-8057 (1986).
3. Hanover J. A., FASEB J., 15, 1865-1876 (2001).
4. Wells L., Vosseller K., Hart G. W., Science, 291, 2376-2378 (2001).
5. Vosseller K., Sakabe K., Wells L., Hart G. W., Curr. Opin. Chem. Biol., 6, 851-857 (2002).
6. Comer F. I., Hart G. W., J. Biol. Chem., 275, 29179-29182 (2000).
7. Haltiwanger R. S., Blomberg M. A., Hart G. W., J. Biol. Chem., 267, 9005-9013 (1992).
8. Lubas W. A., Frank D. W., Krause M., Hanover J. A., J. Biol. Chem., 272, 9316-9324 (1997).
9. Kreppel L. K., Blomberg M. A., Hart G. W., J. Biol. Chem., 272, 9308-9315 (1997).
10. Kreppel L. K., Hart G. W., J. Biol. Chem., 274, 32015-32022 (1999).
11. Lubas W. A., Hanover J. A., J. Biol. Chem., 275, 10983-10988 (2000).
12. Okuyama R., Marshall S., J. Neurochem., 86, 1271-1280 (2003).
13. Akimoto Y., Kreppel L. K., Hirano H., Hart G. W., Diabetes, 48, 2407-2413 (1999).
14. Marshall S., Duong T., Orbus R. J., Rumberger J. M., Okuyama R., Anal. Biochem., 314, 169-179 (2003).
15. Marshall S., Duong T., Wu T., Hering M. A., Yada J., Higgins S., Orbus R. J., Yan Z.-H., Rumberger J. M., Anal. Biochem., 319, 304-313 (2003).
16. Marshall S., Heidenreich K. A., Horikoshi H., J. Biol. Chem., 260, 4128-4135 (1985).