Synthesis and anticancer activities of 5,6,7-trimethylbaicalein derivatives

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 10, 2004, Pages 1162-1165

  Liao, Hua Lin ^a   Hu, Ming Kuan ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Anticancer agent; MTT assay; Trimethylbaicalein derivative

Indexed keywords

2' METHOXY 5,6,7 TRIMETHYLBAICALEIN; 3' HYDROXY 5,6,7 TRIMETHYLBAICALEIN; 3' METHOXY 5,6,7 TRIMETHYLBAICALEIN; 3,4,5 TRIMETHOXYPHENOL; 3,6' DIHYDROXY 2',3',4' TRIMETHOXYCHALCONE; 4' AMINO 5,6,7 TRIMETHYLBAICALEIN; 4' METHOXY 5,6,7 TRIMETHYLBAICALEIN; 4' NITRO 5,6,7 TRIMETHYLBAICALEIN; 5,6,7 TRIMETHYLBAICALEIN; 6' HYDROXY 2',3',4' TRIMETHOXY 4 NITROCHALCONE; 6' HYDROXY 2',3',4' TRIMETHOXYCHALCONE; 6' HYDROXY 2',3',4',4 TETRAMETHOXYCHALCONE; 6' HYDROXY 2',3,3',4' TETRAMETHOXYCHALCONE; 6' HYDROXY 2,2',3',4' TETRAMETHOXYCHALCONE; BAICALEIN; CHALCONE DERIVATIVE; CHLORIDE; CINNAMIC ACID DERIVATIVE; DIMETHYL SULFOXIDE; FLAVONOID; PHENOL DERIVATIVE; SCUTELLARIAE RADIX; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; FLAVANONE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN HEPG2; CELL VIABILITY; COLORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLIZATION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INHIBITION KINETICS; NITROBLUE TETRAZOLIUM TEST; PROSTATE CANCER; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; SCUTELLARIA BAICALENSIS; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVANONES; HUMANS; SCUTELLARIA BAICALENSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 16644369169     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.52.1162     Document Type: Article

References (16)

1. This is part of the master's thesis of Ms. H.-L. Liao.
2. Gao D., Sakurai K., Chen J., Ogiso T., Res. Commun. Mol. Pathol. Pharmacol., 90, 103-114 (1995).
3. Okita K., Li Q., Murakamio T., Takahashi M., Eur. J. Cancer Prev., 2, 169-175 (1993).
4. Kato M., Liu W., Yi H., Asai N., Hayakawa A., Kozaki K., Takahashi M., Nakashima I., J. Invest. Dermatol., 111, 640-644 (1998).
5. Chang W. H., Chen C. H., Lu F. J., Planta Medica, 68, 128-132 (2002).
6. Ikemoto S., Sugimura K., Yoshida N., Yasumoto R., Wada S., Yamamoto K., Kishimoto T., Urology, 55, 951-955 (2000).
7. Pidgeon G. P., Kandouz M., Meram A., Honn K. V., Cancer Res., 62, 2721-2727 (2002).
8. Griggs J., Skepper J. N., Smith G. A., Brindle K. M., Metcalfe J. C., Hesketh R., Am. J. Pathol., 160, 1097-1103 (2002).
9. Gerwick W. H., Lopez A., Van Duyne G. D., Clardy J., Oritz W., Baez A., Tetrahedron Lett., 27, 1979-1982 (1986).
10. Pinto Diana C. G. A., Silva Artur M. S., Cavaleiro Jose A. S., J. Heterocyclic Chem., 33, 1887-1893 (1996).
11. Mosmann T., J. Immunol. Methods, 65, 55-63 (1983).
12. Chan F. L., Choi H. L., Chen Z. Y., Chan Peter S. F., Huang Y., Cancer Lett., 160, 219-228 (2000).
13. Franciso A., Jerome D., Phytochemistry, 3, 753-755 (1988).
14. Farkas L., Mezey-Vander G., Norgradi M., Chem. Ber., 104, 2646-2647 (1971).
15. Gaukroger K., Hadfield J. A., Lawrence N. J., Nolan S., McGrown A. T., Org. Biomolec. Chem., 1, 3033-3037 (2003).
16. Nam N.-H., Curr. Med. Chem., 10, 1697-1722 (2003).