DSCR2, a Down syndrome critical region protein, is localized to the endoplasmic reticulum of mammalian cells

European Journal of Histochemistry

Volumn 48, Issue 3, 2004, Pages 267-272

  Possik, P A ^a   Sommer, C A ^a   Hori, J Issa ^a   Machado Santelli, G M ^b   Jamur, M C ^b   Henrique Silva, F ^a  

^a FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Down syndrome; DSCR2; Endoplasmic reticulum; Immunolocalization

Indexed keywords

DSCR2 PROTEIN, HUMAN; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MEMBRANE PROTEIN; MUSCLE PROTEIN;

ANIMAL; ARTICLE; CELL LINE; CELL STRAIN COS1; CERCOPITHECUS; CHO CELL; DOWN SYNDROME; ENDOPLASMIC RETICULUM; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; SITE DIRECTED MUTAGENESIS; ULTRASTRUCTURE;

ANIMALS; CELL LINE; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; DOWN SYNDROME; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MUSCLE PROTEINS; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION;

EID: 16644365706     PISSN: 1121760X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Berridge MJ. The endoplasmic reticulum: a multifunctional signaling organelle. Cell Calcium 2002;32:235-49.
2. Cheng G, Liu BF, Yu Y, Diglio C, Kuo TH. The exit from G(0) into the cell cycle requires and is controlled by sarco(endo)plasmic reticulum Ca2+ pump. Arch Biochem Biophys 1996;329:65-72.
3. Delabar JM, Theophile D, Rahmani Z, Chettouh Z, Blouin JL, Prieur M, et al. Molecular mapping of twenty-four features of Down syndrome on chromosome 21. Eur J Hum Genet 1993;1:114-24.
4. Fong CT, Broudeur GM. Down's syndrome and leukemia: epidemiology, genetics, cytogenetics and mechanisms of leukemogenesis. Cancer Genet Cytogenet 1987;28:55-76.
5. Hasle H, Clemmensen IH, Mikkelsen M. Pattern of malignant disorders in individuals with Down's syndrome. Lancet 2000;335:165-9.
6. Hassold TJ, Jacobs PA.Trisomy in man. Annu Rev Genet 1984;18:69-97.
7. Jackson MR, Nilsson T, Peterson AP. Retrieval of transmembrane proteins to the endoplasmic reticulum. J Cell Biol 1993;121-2:317-33.
8. Korenberg JR, Bradley C, Disteche CM. Down syndrome: Molecular Mapping of the Congenital Heart Disease and Duodenal Stenosis. Am J Hum Genet 1992;50:294-302.
9. Korenberg JR, Chen XN, Schipper R, Sun Z, Gonsky R, Gerwehr S, et al. Down syndrome phenotypes: the consequences of chromosomal imbalance. Proc Natl Acad Sci USA 1994;91:4997-5001.
10. Lejeune J, Gauthier M, Turpin R. Le Mongolisme, premier example d'aberration autossomique humaine. Ann Gènèt C R Acad Sci (Paris) 1959;248:1721-2.
11. Mao R, Zielke CL, Zielke HR, Pevsner J. Global up-regulation of chromosome 21 gene expression in the developing down syndrome brain. Genomics 2003;81:457-67.
12. Martine G, Mattola G, Pascale MC, Malagolini N, Turrini H, SerafiniCessi F, et al. J Biol Chem 1996;16:3541-7.
13. Pelham HRB. Sorting and retrieval between the endoplasmic reticulum and the Golgi apparatus. Cur Opin Cell Biol 1995;7:530-5.
14. Rahmani Z, Blouin JL, Creau Goldberg N, Watkins PC, Mattei J F, Poissonnier M, et al. Critical Role of the D21S55 Region on Chromosome 21 in the Pathogenesis of Down Syndrome. Proc Natl Acad Sci USA 1986;86:5958-62.
15. Robinson LL. Down syndrome and leukemia. Leukemia 1992;6:5-7.
16. Teasdale RD, Jackson MR. Signal-Mediated sorting of membrane proteins between the endoplasmic reticulum and the golgi apparatus. Annu Rev Cell Dev Biol 1996;12:27-54.
17. van Vliet C, Thomas EC, Merino-Trigo A, Teasdale RD, Gleeson PA. Intracellular sorting and transport of proteins. Prog Biophys Mol Biol 2003;83:1-45.
18. Vidal-Taboada JM, Sanz S, Egeo A, Scartezzini P, Oliva R. Identification and characterization of a new gene from Human Chromosome 21 between markers D21S343 and D21S268 encoding a leucine-rich protein. Biochem Biophys Res Commun 1998; 250: 547-554.
19. Vidal-Taboada JM, Lu A, Pique M, Pons G, Gil J, Oliva R. Down Syndrome Critical Region Gene 2: Expression during mouse development and in human cell lines indicates a function related to cell proliferation. Biochem Biophys Res Commun 2000; 272:156-63.
20. Yang Q, Rasmussen SA, Friedman JM. Mortality associated with Down's syndrome in the USA from 1983 to 1997: a population-based study. Lancet 2002;359:1019-25.