Tissue spectroscope: A novel in vivoapproach to real time monitoring of tissue vitality

Journal of Biomedical Optics

Volumn 9, Issue 5, 2004, Pages 1028-1045

  Mayevsky, Avraham ^a,b   Manor, Tamar ^b   Pevzner, Eliyahu ^b   Deutsch, Assaf ^b   Etziony, Revital ^b   Dekel, Nava ^b   Jaronkin, Alex ^b  

^a BAR ILAN UNIVERSITY   (Israel)

^b Vital Medical Ltd   (Israel)

Author keywords

Laser Doppler flowmetry; Mitochondrial function; Multiparametric monitoring; Real time tissue vitality; Reduced nicotinamide adenine dinucleotide redox state; Tissue spectroscopy

Indexed keywords

BLOOD; BLOOD VESSELS; DIAGNOSIS; FLUORESCENCE; FLUOROMETERS; LIGHT REFLECTION; MONITORING; PROBES; STATISTICAL METHODS; TISSUE;

LASER DOPPLER FLOWMETRY; MITOCHONDRIAL FUNCTION; MULTIPARAMETRIC MONITORING; REAL TIME TISSUE VITALITY; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE REDOX STATE; TISSUE SPECTROSCOPY;

SPECTROGRAPHS;

ANIMALIA;

NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL; ARTICLE; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING ORGAN SYSTEMS; BRAIN; CELL RESPIRATION; CELL SURVIVAL; COMPARATIVE STUDY; EQUIPMENT; EQUIPMENT DESIGN; EVALUATION; GERBIL; INSTRUMENTATION; INTESTINE; MALE; METABOLISM; METHODOLOGY; MICROCIRCULATION; MITOCHONDRION; ONLINE SYSTEM; OXYGEN CONSUMPTION; PHYSIOLOGY; PILOT STUDY; RAT; SPECTROSCOPY; VALIDATION STUDY; VASCULARIZATION;

ANIMALS; BRAIN; CELL RESPIRATION; CELL SURVIVAL; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; GERBILLINAE; INTESTINES; MALE; MICROCIRCULATION; MITOCHONDRIA; NAD; ONLINE SYSTEMS; OXYGEN CONSUMPTION; PILOT PROJECTS; RATS; SPECTRUM ANALYSIS; TISSUE SURVIVAL;

EID: 16544373721     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.1780543     Document Type: Article

References (92)

1. J. Boldt, "Clinical review: hemodynamic monitoring in the intensive care unit," Clin. Crit. Care Med. 6, 52-59 (2002). (Pubitemid 34162857)
2. M. P. Fink, "Cytopathic hypoxia. Is oxygen use impaired in sepsis as a result of an acquired intrinsic derangement in cellular respiration?" Crit. Care Clin. 18, 165-175 (2002). (Pubitemid 34226475)
3. B. Chance, N. Oshino, T. Sugano, and A. Mayevsky, "Basic principles of tissue oxygen determination from mitochondrial signals," in Oxygen Transport to Tissue. Instrumentation, Methods, and Physiology, H. I. Bicher and D. F. Bruley, Eds., pp. 277-292, Plenum, New York (1973).
4. K. Wardell, I. M. Braverman, D. G. Silverman, and G. E. Nilsson, "Spatial heterogeneity in normal skin perfusion recorded with laser Doppler imaging and flowmetry," Microvasc. Res. 48, 26-38 (1994). (Pubitemid 24259710)
5. G. F. Clough, A. R. Bennett, and M. K. Church, "Effects of H1 antagonists on the cutaneous vascular response to histamine and bradykinin: a study using scanning laser Doppler imaging," Br. J. Dermatol. 138, 806-814 (1998). (Pubitemid 28231521)
6. F. F. Jobsis, "Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters," Science 198, 1264-1267 (1977). (Pubitemid 8308546)
7. A. Villringer and B. Chance, "Non-invasive optical spectroscopy and imaging of human brain function," Trends Neurosci. 20, 435-442 (1997). (Pubitemid 27421703)
8. A. Villringer, J. Planck, C. Hock, L. Schleinkofer, and U. Dirnagl, "Near infrared spectroscopy (NIRS): a new tool to study hemodynamic changes during activation of brain function in human adults," Neurosci. Lett. 154, 101-104 (1993). (Pubitemid 23172331)
9. U. Dirnagl, B. Kaplan, M. Jacewicz, and W. Pulsinelli, "Continuous measurement of cerebral cortical blood flow by Laser Doppler Flowmetry with a rat stroke model," J. CBFMetab. 9, 589-596 (1989). (Pubitemid 19239477)
10. R. L. Haberl, M. L. Heizer, A. Marmarou, and E. F. Ellis, "Laser Doppler assessment of brain microcirculation: effect of systemic alterations," Am. J. Physiol. 256, H1247-H1254 (1989).
11. 2 and outcome after severe head injury," Neurol. Res. 20(Suppl 1:S71-5), S71-S75 (1998). (Pubitemid 28223674)
12. K. H. Frank, M. Kessler, K. Appelbaum, and W. Dummler, "The Erlangen micro-lightguide spectrophotometer EMPHO I," Phys. Med. Biol. 34, 1883-1900 (1989). (Pubitemid 20004955)
13. I. J. Rampil, L. Litt, and A. Mayevsky, "Correlated, simultaneous, multiple-wavelength optical monitoring in vivo of localized cerebrocortical NADH and brain microvessel hemoglobin oxygen saturation," J. Clin. Monit 8, 216-225 (1992).
14. B. Chance and G. R. Williams, "Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization," J. Biol. Chem. 217, 383-393 (1955).
15. A. Mayevsky and B. Chance, "Anew long-term method for the measurement of NADH fluorescence in intact rat brain with implanted cannula," in Proc. Int. Symp. on Oxygen Transport to Tissue. Adv. Exp. Med. Biol., pp. 239-244, Plenum Press, New York (1973).
16. M. Rosenthal and F. F Jobsis, "Intracellular redox changes in functioning cerebral cortex. II. Effects of direct cortical stimulation," J. Neurophysiol. 34, 750-762 (1971).
17. E. Dora, "A simple cranial window technique for optical monitoring of cerebrocortical microcirculation and NAD/NADH redox state. Effect of mitochondrial electron transport inhibitors and anoxic anoxia," J. Neurochem. 42, 101-108 (1984). (Pubitemid 14216957)
18. E. Dora, L. Gyulai, and A. G. B. Kovach, "Determinants of brain activation-induced cortical NAD/NADH responses in vivo," Brain Res. 299, 61-72 (1984). (Pubitemid 14143639)
19. F. F. Jobsis, M. O'Connor, A. Vitale, and H. Vreman, "Intracellular redox changes in functioning cerebral cortex. I. Metabolic effects of epileptiform activity," Neurophysiology 34, 735-749 (1971).
20. A. Mayevsky and B. Chance, "Intracellular oxidation reduction state measured in situ by a multichannel fiber-optic-surface fluorometer," Science 217, 537-540 (1982). (Pubitemid 12099335)
21. A. Mayevsky, "Brain NADH redox state monitored in vivo by fiber optic surface fluorometry," Brain Res. Rev. 7, 49-68 (1984). (Pubitemid 14126013)
22. P. Shepherd and P. A. Oberg, Laser Doppler Blood Flowmetry, Kluwer Academic, Naswell USA, (1990).
23. R. Bonner and R. Nossal, "Model for laser Doppler measurements of blood flow in tissue," Appl. Opt. 20, 2097-2107 (1981). (Pubitemid 11521007)
24. A. Javan, W. R. Bennett, and D. R. Herriott, "Population invertion and continuous optical laser oscillation in a gas discharge containing a He-Ne mixture," Phys. Rev. Lett. 6, 106-110 (1961).
25. Y Yeh and H. Cummins, "Localized fluid flow measurements with an He-Ne laser spectometer," Appl. Phys. Lett. 4, 176-178 (1964).
26. C. Riva, B. Ross, and G. B. Benedek, "Laser Doppler measurements of blood flow in capillary tubes and retinal arteries," Invest. Ophthalmol. 11, 936-944 (1972).
27. M. D. Stern, "In vivo evaluation of microcirculation by coherent light scattering," Nature (London) 254, 56-58 (1975).
28. M. D. Stern, D. L. Lappe, P. D. Bowen, J. E. Chimosky, G. A. Holoway, and H. R. Keiser, "Continuous measurement of tissue blood flow by Laser Doppler spectroscopy," Am. J. Physiol. 232, H441-H448 (1977).
29. P. A. Oberg, "Laser-Doppler flowmetry," Crit. Rev. Biomed. Eng. 18, 125-163 (1990).
30. A. N. Obeid, G. Dougherty, and S. Pettinger, "In vivo comparison of a twin wavelength laser Doppler flowmeter using He-Ne and laser diode sources," J. Med. Eng. Technol. 14, 102-110 (1990). (Pubitemid 20231231)
31. M. D. Stern, P. D. Bowen, R. Parma, R. W. Osgood, R. L. Bowman, and J. H. Stein, "Measurement of renal cortical and medullary blood flow by laser-Doppler spectroscopy in the rat," Hokkaido Math. J. 236, F80-F87 (1979). (Pubitemid 9115178)
32. G. Belcaro, U. Hoffmann, A. Bollinger, and A. Nicolaides, Laser Doppler, Med-Orion Publishing, London, Los-Angeles, Nicosia (1994).
33. N. Vongsavan and B. Matthews, "Some aspects of the use of laser Doppler flow meters for recording tissue blood flow," Exp. Physiol. 78, 1-14 (1993).
34. A. Mayevsky, K. Frank, M. Muck, S. Nioka, M. Kessler, and B. Chance, "Multiparametric evaluation of brain functions in the Mongolian gerbil in vivo," J. Basic Clin. Physiol. Pharmacol. 3, 323-342 (1992). (Pubitemid 23247360)
35. A. Mayevsky, "Cerebral blood flow and brain mitochondrial redox state responses to various perturbations in gerbils," in Oxygen Transport to Tissue XIV, W. Erdmann, Ed., pp. 707-716, Plenum Press, New York, London (1992). (Pubitemid 23043646)
36. A. Mayevsky, E. Yoles, N. Zarchin, and D. Kaushansky, "Brain vascular ionic and metabolic responses to ischemia in the Mongolian gerbil," J. Basic Clin. Physiol. Pharmacol. 1, 207-220 (1990).
37. A. Mayevsky, E. S. Flamm, W. Pennie, and B. Chance, "A fiber optic based multiprobe system for intraoperative monitoring of brain functions," Proc. SPIE 1431, 303-313 (1991). (Pubitemid 21688423)
38. A. Mayevsky, A. Doron, T. Manor, S. Meilin, N. Zarchin, and G. E. Ouaknine, "Cortical spreading depression recorded from the human brain using a multiparametric monitoring system," Brain Res. 740, 268-274 (1996). (Pubitemid 26411309)
39. D. W. Lubbers, "Optical sensors for clinical monitoring," Acta Anaesthesiol. Scand., Suppl. 39, 37-54 (1995).
40. B. Chance and H. Baltscheffsky, "Respiratory enzymes in oxidative phosphorylation," J. Biol. Chem. 233, 736-739 (1958).
41. B. Chance, B. Schoener, R. Oshino, F Itshak, and Y Nakase, "Oxidation-reduction ratio studies of mitochondria in freeze-trapped samples. NADH and flavoprotein fluorescence signals," J. Biol. Chem. 254, 4764-4771 (1979).
42. 31P-NMR and NAD(P)H fluorescence study," Biochim. Biophys. Acta 893, 398-408 (1987).
43. T. Galeotti, G. D. V. van Rossum, D. Mayer, and B. Chance, "Spectrofluorimetric detection of 'free' and 'bound' forms of NAD(P)H in normal and tumoral cells," in Atti del Seminario di Studi Biologici, E. Quagliariello, Ed., pp. 249-270, Adriatica Editrice, Bari (1969).
44. E. Kohen, C Kohen, and B. Thorell, "Use of microfluorimetry to study the metabolism of intact cells," Biomed. Eng. 4, 554-565 (1969).
45. J. Eng, R. M. Lynch, and R. S. Balaban, "Nicotinamide adenine dinucleotide fluorescence spectroscopy and imaging of isolated cardiac myocytes," Biophys. J. 55, 621-630 (1989). (Pubitemid 19089843)
46. B. Chance, P. Cohen, F. Jobsis, and B. Schoener, "Intracellular oxidation-reduction states in vivo," Science 137, 499-508 (1962).
47. D. J. Pappajohn, R. Penneys, and B. Chance, "NADH spectrofluorometry of rat skin," J. Appl. Physiol. 33, 684-687 (1972).
48. A. P. Koretsky, L. A. Katz, and R. S. Balaban, "Determination of pyridine nucleotide fluorescence from the perfused heart using an internal standard," Am. J. Physiol. 253, H856-H862 (1987).
49. B. Chance, "Biochemical studies of transitions from rest to activity," V in Sleep and Altered States of Consciousness, pp. 48-63, The Williams & Wilkins Company, Baltimore, (1967).
50. T. M. Sundy and R. E. Anderson, "Reduced nicotinamide adenine dinucleotide fluorescence and cortical blood flow in ischemic and nonischemic squirrel monkey cortex. I. Animal preparation, instrumentation, and validity of model," Stroke 6, 270-278 (1975).
51. K. Harbig, B. Chance, A. G. B. Kovach, and M. Reivich, "In vivo measurement of pyridine nucleotide fluorescence from cat brain cortex," J. Appl. Physiol. 41, 480-488 (1976).
52. B. Chance, "Pyridine nucleotide as an indicator of the oxygen requirements for energy-linked functions of mitochondria," Circ. Res. 38, I-31-I-37 (1976).
53. M. J. O'Connor, D. V. Lewis, and C. J. Herman, "Effects of potassium on oxidative metabolism and seizures," Electroencephalogr. Clin. Neurophysiol. 35, 205-208 (1973).
54. M. Rosenthal and G. Somjen, "Spreading depression of cerebral cortex of cats," J. Neurophysiol. 36, 739-749 (1973).
55. F. F. Jobsis, J. H. Keizer, J. C. LaManna, and M. Rosenthal, "Reflectance spectrophotometry of cytochrome aa3 in vivo," J. Appl. Physiol. 43, 858-872 (1977). (Pubitemid 8238308)
56. J. C. LaManna, G. Watkins, and M. Rosenthal, "Relationship of inspired oxygen level of cytochrome a and ECoG in cats," Physiologist 18, 284 (1975).
57. M. Rosenthal, J. C. LaManna, F. F. Jobsis, J. E. Levasseur, H. A. Kontos, and J. L. Patterson, "Effects of respiratory gases on cytochrome Ain intact cerebral cortex: is there a critical Po2?" Brain Res. 108, 143-154 (1976).
58. B. Chance, A. Mayevsky, C. Goodwin, and L. Mela, "Factors in oxygen delivery to tissue," Microvasc. Res. 8, 276-282 (1974).
59. J. T. Cummins and H. W. Elliott, "Effect of morphine on the potassium-induced change in the level of reduced pyridine nucleotides and cytochromes in brain slices," Biochem. Pharmacol. 25, 893-896 (1976).
60. R. S. Balaban and L. J. Mandel, "Coupling of aerobic metabolism to active ion transport in the kidney," J. Physiol. (London) 304, 331-348 (1980). (Pubitemid 10034385)
61. R. S. Balaban, L. J. Mandel, S. P. Soltoff, and J. M. Storey, "Coupling of active ion transport and aerobic respiratory rate in isolated renal tubules," Proc. Natl. Acad. Sci. U.S.A. 77, 447-451 (1980).
62. H. Franke, C. H. Barlow, and B. Chance, "Surface fluorescence of reduced pyridine nucleotide of the perfused rat kidney: interrelation between metabolic and functional states," Contrib Nephrol. 19, 240-247 (1980).
63. 2 consumption of rat hepatocytes," Am. J. Physiol. 242, C172-C177 (1982). (Pubitemid 12100006)
64. S. Ji, J. J. Lemasters, and R. G. Thurman, "Anon-invasive method to study metabolic events within sublobular regions of hemoglobin-free perfused liver," FEBS Lett. 113, 37-41 (1980).
65. T. Kitai, A. Tanaka, A. Tokuka, K. Ozawa, S. Iwata, and B. Chance, "Changes in the redox distribution of rat liver by ischemia," Anal. Biochem. 206, 131-136 (1992).
66. 2 balance in local myocardial regions in vivo," Q. J. Exp. Physiol. 66, 501-514 (1981). (Pubitemid 12216460)
67. C. Ince, J. F. Ashruf, J. A. M. Avontuur, P. A. Wieringa, J. A. E. Spaan, and H. A. Bruining, "Heterogeneity of the hypoxic state in rat heart is determined at capillary level," Am. J. Physiol. 264, H294-H301 (1993). (Pubitemid 23081095)
68. G. Renault, E. Raynal, M. Sinet, M. Muffat-Joly, J.-P Berthier, J. Cornillault, B. Godard, and J.-J. Pocidalo, "In situ double-beam NADH laser fluorimetry: choice of a reference wavelength," Am. J. Physiol. 246, H491-H499 (1984). (Pubitemid 14148840)
69. F. F Jobsis, M. J. O'Conner, M. Rosenthal, and J. M. VanBuren, "Fluorometric monitoring of metabolic activity in the intact cerebral cortex," 253 in Neurophysiology Studied in Man, pp. 18-26, Excerpta Medica, Amsterdam (1971).
70. A. Mayevsky and B. Chance, "Repetitive patterns of metabolic changes during cortical spreading depression of the awake rat," Brain Res. 65, 529-533 (1974).
71. S. Ji, B. Chance, B. H. Stuart, and R. Nathan, "Two-dimensional analysis of the redox state of the rat cerebral cortex in vivo by NADH fluorescence photography," Brain Res. 119, 357-373 (1977). (Pubitemid 8006252)
72. A. Mayevsky and B. Chance, "The effect of decapitation on the oxidation-reduction state of NADH and ECoG in the brain of the awake rat," in Oxygen Transport to Tissue II, Adv. Exp. Med. Biol., pp. 307-312 (1976).
73. A. Mayevsky, "Ischemia in the brain: The effects of carotid artery ligation and decapitation on the energy state of the awake and anesthetized rat," Brain Res. 140, 217-230 (1978). (Pubitemid 8247833)
74. A. Mayevsky and N. Zarchin, "The effects of unilateral carotid occlusion on the responses to decapitation in the gerbil brain," Brain Res. 206, 155-160 (1981). (Pubitemid 11143582)
75. N. Zarchin and A. Mayevsky, "The effects of age on the metabolic and electrical responses to decapitation in the awake and anesthetized rat brain," Mech. Ageing Dev 16, 285-294 (1981). (Pubitemid 11054830)
76. A. Mayevsky, "Level of ischemia and brain functions in the Mongolian gerbil in vivo," Brain Res. 524, 1-9 (1990). (Pubitemid 20254688)
77. G. E. Nilsson, T. Tenland, and P. A. Obert, "A new instrument for continuous measurement of tissue blood flow by light beating spectroscopy," IEEE Trans. Biomed. Eng. 27, 12-19 (1980).
78. J. M. Bland and D. G. Altman, "Statistical methods for assessing agreement between two methods of clinical measurement," Lancet 1, 307-310 (1986). (Pubitemid 16134762)
79. J. M. Bland and D. G. Altman, "Comparing methods of measurement: why plotting difference against standard method is misleading," Lancet 346, 1085-1087 (1995).
80. A. Mayevsky, N. Zarchin, and C. M. Friedli, "Factors affecting the oxygen balance in the awake cerebral cortex exposed to spreading depression," Brain Res. 236, 93-105 (1982). (Pubitemid 12184982)
81. P. G. Cordeiro, R. E. Kirschner, Q.-Y. Hu, J. J. C. Chiao, H. Savage, R. R. Alfano, L. A. Hoffman, and D. A. Hidalgo, "Ultraviolet excitation fluorescence spectroscopy: A noninvasive method for the measurement of redox changes in ischemic myocutaneous flaps," Plast. Reconstr. Surg. 96, 673-680 (1995).
82. C.-S. Orr and S. C. Arthurs, "Tissue viability measurement by in situ fluorometry," ASAIO Trans. 38, M412-M415 (1992).
83. R. L. White and B. A. Wittenberg, "NADH fluorescence of isolated ventricular myocytes: effects of pacing, myoglobin, and oxygen supply," Biophys. J. 65, 196-204 (1993). (Pubitemid 23206053)
84. 2A receptor agonist and antagonist," Eur. J. Pharmacol. 287, 295-302 (1995). (Pubitemid 26006341)
85. M. Spraycar, Stedman's Medical Dictionary, Williams & Wilkins, Baltimore (1995).
86. E. Dora, "Effect of 'flow anoxia' and 'non flow anoxia' on the NAD/ NADH redox state of the intact brain cortex of the cat," Pfluegers Arch. Eur. J. Physiol. 405, 148-154 (1985). (Pubitemid 16255604)
87. M. Kaminogo, "Changes of cortical oxidative metabolism and cortical oxygen tension in hypoxia, anoxia and ischaemia," Neurol. Res. 11, 139-144 (1989). (Pubitemid 19274851)
88. R. E. Anderson and T. M. Sundt, Jr., "Instrumentation for in vivo cerebral NADH studies in squirrel monkey," IEEE Trans. Biomed. Eng. BME-22, 220-224 (1975).
89. D. J. Godden, E. M. Baile, and P. D. Pare, "A comparison of laser Doppler flowmetry with the radiolabelled microsphere reference flow technique to measure tracheal blood flow in dogs," Acta Physiol. Scand. 142, 49-57 (1991).
90. G. J. Smits, R. J. Roman, and J. H. Lombard, "Evaluation of laserDoppler flowmetry as a measure of tissue blood flow," J. Appl. Physiol. 61, 666-672 (1986). (Pubitemid 16025225)
91. T. Manor, A. Meilin, and A. Mayevsky, "Monitoring different areas of the rat cortex in response to fluid percussion trauma," Isr J. Med. Sci. 32(Suppl.), S39 (1996).
92. A. Kraut, Y. Zurovsky, and A. Mayevsky, "Simultaneous hemodynamic and metabolic responses to oxygen deficiency in the brain and other organs of the rat," Neurosci. Lett. Suppl. 51, S24 (1998) (Abstract).