PTEN and other tumor suppressor gene mutations as secondary genetic alterations in synovial sarcoma

Oncology Reports

Volumn 11, Issue 5, 2004, Pages 1011-1015

  Saito, Tsuyoshi ^a   Oda, Yoshinao ^a   Kawaguchi, Ken Ichi ^a   Takahira, Tomonari ^a   Yamamoto, Hidetaka ^a   Tanaka, Kazuhiro ^a   Matsuda, Shuichi ^a   Sakamoto, Akio ^a   Iwamoto, Yukihide ^a   Tsuneyoshi, Masazumi ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Molecular target; Prognosis; PTEN; Synovial sarcoma; Tumor suppressor genes

Indexed keywords

PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ADULT; ARTICLE; CHILD; CONNECTIVE TISSUE TUMOR; EXON; FEMALE; GENETICS; HUMAN; INTRON; MALE; MIDDLE AGED; MUTATION; NUCLEOTIDE SEQUENCE; PROGNOSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; SURVIVAL; TUMOR SUPPRESSOR GENE;

ADULT; BASE SEQUENCE; CHILD; EXONS; FEMALE; GENES, TUMOR SUPPRESSOR; HUMANS; INTRONS; MALE; MIDDLE AGED; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROGNOSIS; PTEN PHOSPHOHYDROLASE; SARCOMA, SYNOVIAL; SURVIVAL ANALYSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 16544367838     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.11.5.1011     Document Type: Article

References (35)

1. Kawai A, Woodruff J, Healey JH, Brennan MF, Antonescu CR and Ladanyi M: SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med 338: 153-160, 1998. (Pubitemid 28041862)
2. Ladanyi M, Antonescu CR, Leung DH, Woodruff JM, Kawai A, Healey JH, Brennan MF, Bridge JA, Neff JR, Barr FG, Goldsmith JD, Brooks JS, Goldblum JR, Ali SZ, Shipley J, Cooper CS, Fisher C, Skytting B and Larsson O: Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients. Cancer Res 62: 135-140, 2002. (Pubitemid 34073997)
3. Dos Santos NR, De Bruijn DR and Geurts van Kessel A: Molecular mechanisms underlying human synovial sarcoma development. Genes Chromosomes Cancer 30: 1-14, 2001.
4. Ladanyi M: Fusions of the SYT and SSX genes in synovial sarcoma. Oncogene 20: 5755-5762, 2001.
5. Saito T, Oda Y, Sugimachi K, Kawaguchi K, Tamiya S, Tanaka K, Matsuda S, Sakamoto A, Iwamoto Y and Tsuneyoshi M: E-cadherin gene mutations frequently occur in synovial sarcoma as a determinant of histological features. Am J Pathol 159: 2117-2124, 2001. (Pubitemid 33104266)
6. Saito T, Oda Y, Sakamoto A, Kawaguchi K, Tanaka K, Matsuda S, Tamiya S, Iwamoto Y and Tsuneyoshi M: APC mutations in synovial sarcoma. J Pathol 196: 445-459, 2002.
7. Saito T, Oda Y, Sakamoto A, Tamiya S, Kinukawa N, Hayashi K, Iwamoto Y and tsuneyoshi M: Prognostic value of the preserved expression of the E-cadherin and catenin families of adhesion molecules and of 6-catenin mutations in synovial sarcoma. J Pathol 192: 342-350, 2000.
8. Oda Y, Sakamoto A, Saito T, Kawauchi S, Iwamoto Y and Tsuneyoshi M: Molecular abnormalities of p53, MDM2, and H-ras in synovial sarcoma. Mod Pathol 13: 994-1004, 2000.
9. Schneider-Stock R, Onnasch D, Haeckel C, Mellin W, Franke DS and Roessner A: Prognostic significance of p53 gene mutations and p53 protein expression in synovial sarcoma. Virchows Arch 435: 407-412, 1999. (Pubitemid 29472199)
10. Wei G, Antonescu CR, De Alava E, Leung D, Huvos AG, Meyers PA, Healey JH and Ladanyi M: Prognostic impact of INK4A deletion in Ewing sarcoma. Cancer 89: 793-799, 2000. (Pubitemid 30658578)
11. Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH and Tavtigian SV: Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15: 356-362, 1997. (Pubitemid 27147102)
12. Liaw D, Marsh DJ, Li J, Dahia PL, Wang SI, Zheng Z, Bose S, Call KM, Tsou HC, Peacocke M, Eng C and Parsons R: Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 16: 64-67, 1997. (Pubitemid 27198157)
13. Marsh DJ, Dahia PL, Zheng Z, Liaw D, Parsons R, Gorlin RJ and Eng C: Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat Genet 16: 333-334, 1997.
14. Van Gele M, Leonard JH, Van Roy N, Cook AL, De Paepe A and Speleman F: Frequent allelic loss at 10q23 but low incidence of PTEN mutations in Merkel cell carcinoma. Int J Cancer 92: 409-413, 2001. (Pubitemid 32249719)
15. Risinger JI, Hayes K, Maxwell GL, Carney ME, Dodge RK, Barrett JC and Berchuck A: PTEN mutation in endometrial cancers is associated with favorable clinical and pathologic characteristics. Clin Cancer Res 4: 3005-3010, 1998. (Pubitemid 29001474)
16. Maxwell GL, Risinger JI, Hayes KA, Alvarez AA, Dodge RK, Barrett JC and Berchuck A: Racial disparity in the frequency of PTEN mutations, but not microsatellite instability, in advanced endometrial cancers. Clin Cancer Res 6: 2999-3005, 2000. (Pubitemid 30637721)
17. Suzuki H, Freije D, Nusskern DR, Okami K, Cairns P, Sidransky D, Isaacs WB and Bova GS: Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. Cancer Res 58: 204-209, 1998. (Pubitemid 28047054)
18. Celebi JT, Shendrik I, Silvers DN and Peacocke M: Identification of PTEN mutations in metastatic melanoma specimens. J Med Genet 37: 653-657, 2000.
19. Wang SI, Puc J, Li J, Bruce JN, Cairns P, Sidransky D and Parsons R: Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res 57: 4183-4186, 1997. (Pubitemid 27413419)
20. Rhei E, Kang L, Bogomolniy F, Federici MG, Borgen PI and Boyd J: Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. Cancer Res 57: 3657-3659, 1997. (Pubitemid 27381202)
21. Rasheed BK, Stenzel TT, McLendon RE, Parsons R, Friedman AH, Friedman HS and Bigner SH: PTEN gene mutations are seen in high-grade but not in low-grade gliomas. Cancer Res 57: 4187-4190, 1997. (Pubitemid 27413420)
22. Minaguchi T, Yoshikawa H, Oda K, Ishino T, Yasugi T, Onda T, Nakagawa S, Matsumoto K, Kawana K and Taketani Y: PTEN mutation located only outside exons 5, 6, and 7 is an independent predictor of favorable survival in endometrial carcinomas. Clin Cancer Res 7: 2636-2642, 2001. (Pubitemid 32911365)
23. Liu J, Babaian DC, Liebert M, Steck PA and Kagan J: Inactivation of MMAC1 in bladder transitional-cell carcinoma cell lines and specimens. Mol Carcinog 29: 143-150, 2000.
24. Risinger JI, Hayes AK, Berchuck A and Barrett JC: PTEN/MMAC1 mutations in endometrial cancers. Cancer Res 57: 4736-4738, 1997. (Pubitemid 27468978)
25. Cairns P, Okami K, Halachmi S, Halachmi N, Esteller M, Herman JG, Jen J, Isaacs WB, Bova GS, Sidransky D: Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res 57: 4997-5000, 1997. (Pubitemid 27498107)
26. Di Cristofano A and Pandolfi PP: The multiple roles of PTEN in tumor suppression. Cell 100: 387-390, 2000.
27. Ali IU, Schriml LM, Dean M: Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity. J Natl Cancer Inst 91: 1922-1932, 1999.
28. Saito T, Oda Y, Kawaguchi K, Takahira T, Yamamoto H, Tamiya S, Tanaka K, Matsuda S, Sakamoto A, Iwamoto Y and Tsuneyoshi M: PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations. Int J Cancer 104: 175-178, 2003. (Pubitemid 36249792)
29. Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y, Benchimol S and Mak TW: Regulation of PTEN transcription by p53. Mol Cell 8: 317-325, 2001. (Pubitemid 32831549)
30. Wechsler DS, Shelly CA and Dang CV: Genomic organization of human MXI1, a putative tumor suppressor gene. Genomics 32: 466-470, 1996. (Pubitemid 26094352)
31. Lin C, Meitner PA and Terek RM: PTEN mutation is rare in chondrosarcoma. Diagn Mol Pathol 11: 22-26, 2002. (Pubitemid 34171208)
32. Knudson AG Jr, Hethcote HW and Brown BW: Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma. Proc Natl Acad Sci USA 72: 5116-5120, 1975.
33. Lee JO, Yang H, Georgescu MM, Di Cristofano A, Maehama T, Shi Y, Dixon JE, Pandolfi P and Pavletich NP: Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell 99: 323-334, 1999. (Pubitemid 29519911)
34. Saito T, Oda Y, Sakamoto A, Tamiya S, Iwamoto Y and Tsuneyoshi M: Matrix metalloproteinase-2 expression correlates with morphological and immunohistochemical epithelial characteristics in synovial sarcoma. Histopathology 40: 279-285, 2002. (Pubitemid 34227119)
35. Vanhaesebroeck B, Leevers SJ, Ahmadi K, Timms J, Katso R, Driscoll PC, Woscholski R, Parker PJ and Waterfield MD: Synthesis and function of 3-phosphorylated inositol lipids. Annu Rev Biochem 70: 535-602, 2001. (Pubitemid 32662219)