Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors

Journal of Molecular Neuroscience

Volumn 24, Issue 1, 2004, Pages 81-84

  Zeng, Lei ^a   Chen, Ken ^a   Muller, Michaela ^a   Zhou, Ming Ming ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

AMPA receptors; NMR; Rational ligand design

Indexed keywords

AMPA RECEPTOR; COMPLEMENTARY DNA; GLUTAMATE RECEPTOR 2; GLUTAMIC ACID; ION CHANNEL; IONOTROPIC RECEPTOR; KAINIC ACID; LEAD; AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT; GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2; LIGAND; NEUROPROTECTIVE AGENT;

ALZHEIMER DISEASE; ANIMAL CELL; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CONFERENCE PAPER; DRUG DESIGN; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; ENZYME CONFORMATION; EXTRACELLULAR SPACE; FEMALE; IN VITRO SELECTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHYSICAL PARAMETERS; RECEPTOR BINDING; ROBOTICS; STATISTICAL ANALYSIS; STRUCTURE ACTIVITY RELATION; ANIMAL; ARTICLE; BINDING COMPETITION; BINDING SITE; BRAIN; CHEMISTRY; CONFORMATION; DRUG POTENTIATION; HUMAN; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SYNTHESIS;

ALZHEIMER DISEASE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BRAIN; DRUG DESIGN; DRUG SYNERGISM; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HUMANS; ION CHANNELS; KAINIC ACID; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR CONFORMATION; NEUROPROTECTIVE AGENTS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, AMPA;

EID: 16544367432     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/jmn:24:1:081     Document Type: Conference Paper

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