Excavation of lead compounds that inhibit mast cell degranulation by combinatorial chemistry and activity-guided

Archives of Pharmacal Research

Volumn 27, Issue 5, 2004, Pages 518-523

  Hahn, Hoh Gyu ^b   Heong, Sub Oh ^b   Seung, Hoon Cheon ^a   Min, Ho Oak ^a   Kim, Young Ran ^a   Kim, Kyeong Man ^a  

^a Chonnam National University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

1,3 Oxazolidines; Allergy; Castanea crenata; Combinatorial chemistry; Mast cell degranulation; Quercetin

Indexed keywords

LEAD; PLANT EXTRACT;

ANIMAL; ARTICLE; CHEMISTRY; COMBINATORIAL CHEMISTRY; DEGRANULATION; DRUG EFFECT; FAGACEAE; ISOLATION AND PURIFICATION; MAST CELL; METABOLISM; METHODOLOGY; PHYSIOLOGY; PLANT LEAF; RAT;

ANIMALS; CELL DEGRANULATION; COMBINATORIAL CHEMISTRY TECHNIQUES; FAGACEAE; LEAD; MAST CELLS; PLANT EXTRACTS; PLANT LEAVES; RATS;

EID: 16544365647     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02980125     Document Type: Article

References (13)

1. Blank, U., Ra, C., Miller, L., White, K., Metzger, H., and Kinet, J. P., Complete structure and expression in transfected cells of high affinity IgE receptor. Nature, 337, 187-189 (1989).
2. Cambier, J. C., Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J. Immunol., 155, 3281-3285 (1995).
3. Cheong, H., Ryu, S. Y., and Kim, K. M., Anti-allergic action of resveratrol and related hydroxystilbenes. Planta Med., 65, 266-268 (1999).
4. Cheong, H., Ryu, S. Y., Oak, M. H., Cheon, S. H., Yoo, G. S., and Kim, K. M., Studies of structure activity relationship of flavonoids for the anti- allergic actions. Arch. Pharm. Res., 21, 478-480 (1989).
5. Cox, J. S., Disodium cromoglycate (FPL 670) ('Intal'): a specific inhibitor of reaginic antibody-antigen mechanisms. Nature, 216, 1328-1329 (1967).
6. Fischer, M. J., Paulussen, J. J., Horbach, D. A., Roelofsen, E. P., van Miltenburg, J. C., de Mol, N. J., and Janssen, L. H., Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: relation to lipophilicity and membrane effects. Inflamm. Res., 44, 92-97 (1995).
7. Kinet, J. P., The high-affinity receptor for IgE. Curr. Opin. Immunol., 2, 499-505 (1989).
8. Lee, E., Choi, E. J., Cheong, H., Kim, Y. R., Ryu, S. Y., and Kim, K. M., Anti-allergic actions of the leaves of Castanea crenata and isolation of an active component responsible for the inhibition of mast cell degranulation. Arch. Pharm. Res., 22, 320-323 (1999).
9. Oh, H. S., Hahn, H. G., Cheon, S. H., and Ha, D. C., Solid-phase synthesis of 1,3-oxazolidine derivatives. Tetrahedron Lett., 41, 5069-5072 (2000).
10. Reth, M., Antigen receptor tail clue. Nature, 338, 383-384 (1989).
11. Rivera, J., Molecular adapters in Fc(epsilon)RI signaling and the allergic response. Curr. Opin. Immunol., 14, 688-693 (2002).
12. Schwartz, L. B., Austen, K. F., and Wasserman, S. I., Immunologic release of beta-hexosaminidase and beta-glucuronidase from purified rat serosal mast cells. J. Immunol., 123, 1445-1450 (1979).
13. Thompson, L. A. and Ellman, J. A., Synthesis and applications of small molecule libraries. Chem. Rev., 96, 555-600 (1996).