A new in vitro bioassay system for discovery of novel human-use mosquito repellents

Journal of the American Mosquito Control Association

Volumn 21, Issue 1, 2005, Pages 64-70

  Klun, Jerome A ^a   Kramer, Matthew ^a   Debboun, Mustapha ^b  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b US Army Center for Health Promotion and Preventive Medicine South   (United States)

Author keywords

(1S, 2 S) methylpiperidinyl 3 cyclohexen 1 carboxamide; 2 (2 hydroxyethyl) 1 piperidine carboxylic acid 1 methylpropyl ester; Aedes aegypti; Anopheles stephensi; Bayrepel ; Deet; N,N diethyl 3 methylbenzamide; SS 220; Yellow fever mosquito

Indexed keywords

AEDES AEGYPTI; ANOPHELES STEPHENSI; INSECTA;

DIETHYLTOLUAMIDE; INSECT REPELLENT; PICARIDIN; PIPERIDINE DERIVATIVE;

AEDES; ANIMAL; ANOPHELES; ARTICLE; BIOASSAY; HUMAN; IN VITRO STUDY; INSTRUMENTATION; METHODOLOGY; MOSQUITO;

AEDES; ANIMALS; ANOPHELES; BIOLOGICAL ASSAY; CULICIDAE; DEET; HUMANS; INSECT REPELLENTS; PIPERIDINES;

EID: 16444381454     PISSN: 8756971X     EISSN: None     Source Type: Journal    
DOI: 10.2987/8756-971X(2005)21[64:ANIVBS]2.0.CO;2     Document Type: Article

References (18)

1. Barnard DR, Posey KH, Smith D, Schreck CE. 1998. Mosquito density, biting rate and cage size effects on repellent tests. Med and Vet Ent 12:39-45.
2. Bar-Zeev MS, Smith CN. 1959. Action of repellents on mosquitoes feeding through membranes or on treated blood. J Econ Entomol 52:263-267.
3. Cockcroft A, Cosgrove JB, Wood J. 1998. Comparative repellency of commercial formulations of deet, permethrin, and citronellal against the mosquito Aedes aegypti, using a collagen membrane technique compared with human arm tests. Med and Vet Entomol 12:289-294.
4. Collins DA, Brady JN, Curtis CF. 1993. Assessment of the efficacy of quwenling as a mosquito repellent. Phytother Res 7:17-20.
5. Gerberg EJ, Barnard DP, Ward RA. 1994. Manual for mosquito rearing and experimental techniques. Amer Mosq Cont Assoc Bull, no. 5 (revised). AMCA Inc, Lake Charles, LA.
6. Klun JA, Debboun M. 2000. A new module for quantitative evaluation of repellent efficacy using human subjects. J Med Entomol 37:177-181.
7. Klun JA, Khrimian A, Margaryan A, Kramer M, Debboun M. 2003. Synthesis and repellent efficacy of a new chiral piperidine analog: comparison with deet and Bayrepel in human-volunteer assays against Aedes aegypti and Anopheles stephensi. J Med Entomol 40:293-299.
8. Klun JA, Strickman D, Rowton E, Williams J, Kramer M, Roberts D, Debboun M. 2004. Comparative resistance of Anopheles albimanus and Aedes aegypti to N,N-diethyl-3-methylbenzamide (Deet) and 2-methylpiperidinyl-3-cyclohexen-1- carboxamide (AI3-37220) in laboratory human-volunteer repellent assays. J Med Entomol 41:418-422.
9. Rutledge LC, Gupta RK. 2004. Evaluation of an in vitro bloodfeeding system for testing mosquito repellents. J Amer Mosq Cont Assoc 20:150-154.
10. Rutledge LC, Gupta RK, Mehr ZA, Buescher MD, Reifenrath WG. 1996. Evaluation of the laboratory rabbits model for screening topical mosquito repellents. J Amer Mosq Cont Assoc 12:142-143.
11. Rutledge LC, Gupta RK, Wirtz RA, Buescher MD. 1994. Evaluation of the laboratory mouse model for screening topical repellents. J Amer Mosq Cont Assoc 10:565-571.
12. Rutledge LC, Moussa MA, Belletti CJ. 1976. An in vitro bloodfeeding system for quantitative testing of mosquito repellents. Mosq News 36:283-293.
13. Schreck CE. 1977. Techniques for the evaluation of insect repellents: a critical review. Ann Rev Entomol 22:101-119.
14. Schreck CE, Gilbert IH, Weidhaas DE, Posey KH. 1970. Spatial action of mosquito repellents. J Econ Entomol 63:1576-1578.
15. Schreck CE, McGovern TP. 1989. Repellents and other personal protection strategies against Aedes albopictus. J Amer Mosq Cont Assoc 5:247-250.
16. Sharpington PJ, Healy TP, Copland MJW. 2000. A wind tunnel system for screening mosquito repellents. J Amer Mosq Cont Assoc 16:234-240.
17. Snodgrass HL, Houpt JT. 2002. The acute dermal toxicity of the repellent SS-220 In guinea pigs, 17 September-1 October 2002. Toxicology study 85-XC-3929-02, protocol 3929-23-01-07-02. Aberdeen Proving Ground, MD: U.S. Army Center for Health Promotion and Preventative Medicine.
18. Wirtz RA, Turrentine JD Jr, and Rutledge LC. 1980. Mosquito area repellents: laboratory testing of candidate materials against Aedes aegypti. Mosq News 40:430-432.