Expression of Na+/H+ exchanger isoforms in normal human nasal epithelial cells and functional activity of Na+/H + exchanger 1 in intracellular pH regulation

Acta Oto-Laryngologica

Volumn 125, Issue 3, 2005, Pages 286-292

  Shin, Ji Hyun ^a   Namkung, Wan ^a   Kim, Chang Hoon ^a   Choi, Jae Young ^a   Yoo, Jong Bum ^a   Lee, Kyung Dong ^a   Lee, Jeung Gweon ^a   Lee, Min Goo ^a   Yoon, Joo Heon ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Differentiation; Na+ H+ exchanger; Nasal epithelial cells; pH

Indexed keywords

(3 METHYLSULFONYL 4 PIPERIDINOBENZOYL)GUANIDINE METHANESULFONATE; ISOPROTEIN; MESSENGER RNA; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN 2; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL LYSATE; CELL MEMBRANE; CELL PH; CONTROLLED STUDY; HISTOLOGY; HUMAN; HUMAN CELL; NORMAL HUMAN; NOSE MUCOSA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CATION TRANSPORT PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; EPITHELIAL CELLS; GUANIDINES; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR FLUID; MEMBRANE PROTEINS; NASAL MUCOSA; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SODIUM-HYDROGEN ANTIPORTER; SULFONES;

EID: 16444373049     PISSN: 00016489     EISSN: None     Source Type: Journal    
DOI: 10.1080/00016480410022976     Document Type: Article

References (20)

1. Jeffery PK, Li D. Airway mucosa: secretory cells, mucus and mucin genes. Eur Respir J 1997;10:1655-62.
2. - exchanger isoforms in proximal and distal human airways. Am J Physiol 1999;276:L971-8.
3. Welsh MJ. Electrolyte transport by airway epithelia. Physiol Rev 1987;67:1143-84.
4. + exchangers of mammalian cells. J Biol Chem 1997;272:22373-6.
5. Yoon JH, Gray T, Guzman K, Koo JS, Netteshein P. Regulation of the secretory phenotype of human airway epithelium by retinoic acid, triiodothyronine, and extracellular matrix. Am J Respir Cell Mol Biol 1997;16:724-31.
6. Praetorius J, Andreasen D, Jensen BL, Ainsworth MA, Friis UG, Johansen T. NHE1, NHE2, and NHE3 contribute to regulation of intracellular pH in murine duodenal epithelial cells. Am J Physiol Gastrointest Liver Physiol 2000;278: G197-206.
7. Avkiran M. Rational basis for use of sodium-hydrogen exchange inhibitors in myocardial ischemia. Am J Cardiol 1999;83:10G-7G.
8. + antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties. Mol Pharmacol 1993;44:1041-5.
9. Bhaskar KR, Gong DH, Bansil R, Pajevic S, Hamilton JA, Turner BS, et al. Profound increase in viscosity and aggregation of pig gastric mucin at low pH. Am J Physiol 1991;261:G827-32.
10. + exchangers in human airways epithelium. J Pancreas 2001;2:285-90.
11. - exchanger isoforms in human nasal mucosa. Acta Otolaryngol 2002;122:866-71.
12. Reilly RF, Hildebrandt F, Biemesderfer D, Sardet C, Pouyssegur J, Aronson PS, et al. cDNA cloning and immunolocalization of a Na(+)-H+ exchanger in LLC-PK1 renal epithelial cells. Am J Physiol 1991;261;F1088-94.
13. Helmle-Kolb C, Counillon L, Roux D, Pouyssegur J, Mrkic B, Murer H. Na/H exchange activities in NHE1-transfected OK-cells: cell polarity and regulation. Pflugers Arch 1993;425:34-40.
14. + exchangers in the human eccrine sweat duct. Am J Physiol Cell Physiol 2003;285:C1047-58.
15. Lee MG, Ahn W, Choi JY, Luo X, Seo JT, Schultheis PJ, et al. Na(+)-dependent transporters mediate HCO(3)(-) salvage across the luminal membrane of the main pancreatic duct. J Clin Invest 2000;105:1651 -8.
16. + exchange in the human normal and cystic fibrosis airway epithelium. Am J Physiol 1997;273:L148-58.
17. Choi JY, Cho KN, Yoon JH. Effect of uridine 5′-triphosphate on mucin and lysozyme expression in human middle ear epithelial cells. Acta Otolaryngol 2003;123: 362-6.
18. Choi JY, Namkung W, Shin JH, Yoon JH. Uridine-5′-triphosphate and adenosine triphosphate gamma S induce mucin secretion via Ca2+-dependent pathways in human nasal epithelial cells. Acta Otolaryngol 2003;123: 1080-6.
19. Busa WB. Mechanisms and consequences of pH-mediated cell regulation. Annu Rev Physiol 1986;48:389-402.
20. Hwang J, Pouyssegur J, Willingham MC, Pastan I. The role of intracellular pH in ligand internalization. J Cell Physiol 1986;128:18-22.