Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); Inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism

BioFactors

Volumn 21, Issue 1-4, 2004, Pages 127-131

  Osakabe, Naomi ^a   Takano, Hirohisa ^b,c   Sanbongi, Chiaki ^a   Yasuda, Akiko ^a   Yanagisawa, Rie ^b   Inoue, Ken Ichiro ^b   Yoshikawa, Toshikazu ^c  

^a MEIJI SEIKA KAISHA LTD   (Japan)

^b NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Adhesion molecule; Chemokine; Neutrophils; Rosmarinic acid; Seasonal allergic rhinoconjunctivitis

Indexed keywords

CHEMOKINE; CYCLOOXYGENASE 2; INTERCELLULAR ADHESION MOLECULE 1; PHORBOL 13 ACETATE 12 MYRISTATE; ROSMARINIC ACID; VASCULAR CELL ADHESION MOLECULE 1; CINNAMIC ACID DERIVATIVE; DEPSIDE; HISTAMINE H1 RECEPTOR ANTAGONIST; IMMUNOGLOBULIN E; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; PLANT EXTRACT;

ALLERGIC RHINITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; CELL COUNT; CELL INFILTRATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; EAR DISEASE; EDEMA; EOSINOPHIL; HUMAN; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NOSE MUCUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINOCONJUNCTIVITIS; UPREGULATION; ANIMAL; ARTICLE; BLOOD; COMPARATIVE STUDY; DIET SUPPLEMENTATION; DISEASE MODEL; DOUBLE BLIND PROCEDURE; HAY FEVER; LEUKOCYTE COUNT; PHYTOTHERAPY;

ANIMALIA; PERILLA;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CINNAMATES; DEPSIDES; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; DOUBLE-BLIND METHOD; HISTAMINE H1 ANTAGONISTS; HUMANS; IMMUNOGLOBULIN E; LEUKOCYTE COUNT; PHYTOTHERAPY; PLACEBOS; PLANT EXTRACTS; RHINITIS, ALLERGIC, SEASONAL;

EID: 16444371185     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.552210125     Document Type: Conference Paper

References (6)

1. C. Sanbongi, H. Takano, N. Osakabe, N. Sasa, M. Natsume, R. Yanagisawa, K. Inoue, Y. Kato, T. Osawa and T. Yoshikawa, Rosmarinic acid inhibits lung injury induced by diesel exhaust particles, Free Radic Biol Med 34 (2003), 1060-1069.
2. N. Osakabe, A. Yasuda, M. Natsume, C. Sanbongi, Y. Kato, T. Osawa and T. Yoshikawa, Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-GalN)-sensitized mice, Free Radic Biol Med 33 (2002), 798-806.
3. S. Baba, N. Osakabe, M. Natsume and J. Terao, Orally administrated rosmarinic acid is presented as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric acid, Life Science (2004), in press.
4. S. Baba, N. Osakabe, M. Natsume, A. Yasuda, Y. Muto, T. Hiyoshi, H. Takano and T. Yoshikawa, Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake Perilla frutescens extract in human, Eur J Clin Nutr (2004), in press.
5. H. Takano, N. Osakabe, C. Sanbongi, R. Yanagisawa, K. Inoue, A. Yasuda, M. Natsume, S. Baba, E. Ichiishi and T. Yoshikawa, A polyphenolic phytochemical, rosmarinic acid, inhibits seasonal allergic rhinoconjunctivitis in humans, Exp Biol Med (2004), in press.
6. N. Osakabe, A. Yasuda, M. Natsume and T. Yoshikawa, Rosmarinic acid inhibits epidermal inflammatory responses: anti-carcinogenic effect of Perilla frutescens extract in the murine two-stage skin model, Carcinogenesis (2004), in press.