Sulfonyl-phenyl-ureido benzamidines: A novel structural class of potent antimalarial agents

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 8, 2004, Pages 1979-1982

  Leban, Johann ^a   Pegoraro, Stefano ^a   Dormeyer, Matthias ^a   Lanzer, Michael ^b   Aschenbrenner, Andrea ^a   Kramer, Bernd ^a  

^a 4SC AG   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; BENZAMIDINE DERIVATIVE; LACTATE DEHYDROGENASE; UREA DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; COMPUTER MODEL; DRUG ACTIVITY; LIBRARY; PLASMODIUM FALCIPARUM; SCREENING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TECHNOLOGY;

ANIMALS; ANTIMALARIALS; BENZAMIDINES; DRUG EVALUATION, PRECLINICAL; L-LACTATE DEHYDROGENASE; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 1642634633     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.01.083     Document Type: Article

References (8)

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7. 50, the 'inhibition constant', indicates the value in nMol/l at which 50% inhibition occurs.
8. 1H NMR (D6-DMSO).